New analytical method for the study of metabolism of swertiamarin in rats after oral administration by UPLC-TOF-MS following DNPH derivatization

2015 ◽  
Vol 29 (8) ◽  
pp. 1184-1189 ◽  
Author(s):  
Xiuhong Wu ◽  
Shuhan Tang ◽  
Yan Jin ◽  
Yan Zhang ◽  
Masao Hattori ◽  
...  
Keyword(s):  
Oral Administration ◽  
Analytical Method ◽  
Dnph Derivatization ◽  
Tof Ms

New analytical method for the study of the metabolism of gentiopicroside in rats after oral administration by LC-TOF-MS following picolinoyl derivatization

2013 ◽  
Vol 37 (3) ◽  
pp. 237-243 ◽  
Author(s):  
Zhigang Wang ◽  
Shanshan Wang ◽  
Yujia Sun ◽  
Huiyu Wang ◽  
Guang Chen ◽  
...  
Keyword(s):  
Oral Administration ◽  
Analytical Method ◽  
Tof Ms

New analytical method for determination of epimer metabolites in rat plasma after oral administration of Paeoniflorin by UPLC-TOF-MS following picolinoyl derivatization

2017 ◽  
Vol 141 ◽  
pp. 173-179 ◽  
Author(s):  
Zhigang Wang ◽  
Shuhan Tang ◽  
Masao Hattori ◽  
Hailong Zhang ◽  
Ping Wang ◽  
...  
Keyword(s):  
Oral Administration ◽  
Analytical Method ◽  
Rat Plasma ◽  
Tof Ms

Analysis of the constituents in the rat plasma after oral administration of Yin Chen Hao Tang by UPLC/Q-TOF-MS/MS

2008 ◽  
Vol 46 (3) ◽  
pp. 477-490 ◽  
Author(s):  
Xijun Wang ◽  
Wenjun Sun ◽  
Hui Sun ◽  
Haitao Lv ◽  
Zeming Wu ◽  
...  
Keyword(s):  
Oral Administration ◽  
Rat Plasma ◽  
Tof Ms

scholarly journals Identification of absorbed constituents and evaluation of the pharmacokinetics of main compounds after oral administration of yindanxinnaotong by UPLC-Q-TOF-MS and UPLC-QqQ-MS

RSC Advances ◽  
2018 ◽  
Vol 8 (28) ◽  
pp. 15725-15739 ◽  
Author(s):  
Leilei Gong ◽  
Haiyu Xu ◽  
Huijun Yuan ◽  
Lan Wang ◽  
Xiaojie Yin ◽  
...  
Keyword(s):  
Oral Administration ◽  
Cerebrovascular Diseases ◽  
Tof Ms

Yindanxinnaotong capsule (YDXNT), a traditional Chinese formula, has been used to treat cardio-cerebrovascular diseases for several decades.

scholarly journals Simultaneous Determination and Pharmacokinetic Characterization of Glycyrrhizin, Isoliquiritigenin, Liquiritigenin, and Liquiritin in Rat Plasma Following Oral Administration of Glycyrrhizae Radix Extract

Molecules ◽  
2019 ◽  
Vol 24 (9) ◽  
pp. 1816 ◽  
Author(s):  
You Jin Han ◽  
Bitna Kang ◽  
Eun-Ju Yang ◽  
Min-Koo Choi ◽  
Im-Sook Song
Keyword(s):  
Oral Administration ◽  
Analytical Method ◽  
Plasma Concentrations ◽  
Rat Plasma ◽  
Pharmacokinetic Studies ◽  
Elution Time ◽  
Glycyrrhizae Radix ◽  
Single Oral Administration ◽  
Limit Of Quantitation ◽  
Liquid Chromatography Tandem Mass

Glycyrrhizae Radix is widely used as herbal medicine and is effective against inflammation, various cancers, and digestive disorders. We aimed to develop a sensitive and simultaneous analytical method for detecting glycyrrhizin, isoliquiritigenin, liquiritigenin, and liquiritin, the four marker components of Glycyrrhizae Radix extract (GRE), in rat plasma using liquid chromatography-tandem mass spectrometry and to apply this analytical method to pharmacokinetic studies. Retention times for glycyrrhizin, isoliquiritigenin, liquiritigenin, and liquiritin were 7.8 min, 4.1 min, 3.1 min, and 2.0 min, respectively, suggesting that the four analytes were well separated without any interfering peaks around the peak elution time. The lower limit of quantitation was 2 ng/mL for glycyrrhizin and 0.2 ng/mL for isoliquiritigenin, liquiritigenin, and liquiritin; the inter- and intra-day accuracy, precision, and stability were less than 15%. Plasma concentrations of glycyrrhizin, isoliquiritigenin, liquiritigenin, and liquiritin were quantified for 24 h after a single oral administration of 1 g/kg GRE to four rats. Among the four components, plasma concentration of glycyrrhizin was the highest and exhibited a long half-life (23.1 ± 15.5 h). Interestingly, plasma concentrations of isoliquiritigenin and liquiritigenin were restored to the initial concentration at 4–10 h after the GRE administration, as evidenced by liquiritin biotransformation into isoliquiritigenin and liquiritigenin, catalyzed by fecal lysate and gut wall enzymes. In conclusion, our analytical method developed for detecting glycyrrhizin, isoliquiritigenin, liquiritigenin, and liquiritin could be successfully applied to investigate their pharmacokinetic properties in rats and would be useful for conducting further studies on the efficacy, toxicity, and biopharmaceutics of GREs and their marker components.

Analysis of six bioactive components in Semen Ziziphi Spinosae by UPLC-ELSD and UPLC-Q/TOF-MS

2014 ◽  
Vol 6 (15) ◽  
pp. 5856-5864 ◽  
Author(s):  
Xiangsheng Zhao ◽  
Liwei Xie ◽  
Haifeng Wu ◽  
Weijun Kong ◽  
Meihua Yang
Keyword(s):  
Analytical Method ◽  
Ultrasonic Extraction ◽  
Bioactive Components ◽  
Tof Ms

A fast and validated multicomponent analytical method was developed based on ultrasonic extraction, detection by UPLC-ELSD and confirmation by UPLC-Q/TOF-MS.

UPLC/Q-TOF-MS analysis of iridoid glycosides and metabolites in rat plasma after oral administration of Paederia scandens extracts

2015 ◽  
Vol 13 (3) ◽  
pp. 215-221 ◽  
Author(s):  
Dong-Mei WANG ◽  
Yi-Fei XU ◽  
Zhu CHEN ◽  
Lin-Fang HUANG ◽  
Shi-Lin CHEN
Keyword(s):  
Oral Administration ◽  
Iridoid Glycosides ◽  
Rat Plasma ◽  
Ms Analysis ◽  
Paederia Scandens ◽  
Tof Ms

Identification of constituents in Gui-Zhi-Jia-Ge-Gen-Tang by LC-IT-MS combined with LC-Q-TOF-MS and elucidation of their metabolic networks in rat plasma after oral administration

2019 ◽  
Vol 17 (11) ◽  
pp. 803-821 ◽  
Author(s):  
Lu-Lin CHEN ◽  
Can-Hui CHEN ◽  
Xing-Xian ZHANG ◽  
Yi WANG ◽  
Shu-Fang WANG
Keyword(s):  
Oral Administration ◽  
Metabolic Networks ◽  
Rat Plasma ◽  
Tof Ms

scholarly journals UFLC-Q-TOF-MS/MS-Based Screening and Identification of Flavonoids and Derived Metabolites in Human Urine after Oral Administration of Exocarpium Citri Grandis Extract

Molecules ◽  
2018 ◽  
Vol 23 (4) ◽  
pp. 895 ◽  
Author(s):  
Xuan Zeng ◽  
Weiwei Su ◽  
Yuying Zheng ◽  
Hong Liu ◽  
Panlin Li ◽  
...  
Keyword(s):  
Oral Administration ◽  
Human Urine ◽  
Screening And Identification ◽  
Tof Ms
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