scholarly journals Bombesin receptor subtype-3-expressing neurons regulate energy homeostasis through a novel neuronal pathway in the hypothalamus

2017 ◽  
Vol 8 (1) ◽  
pp. e00881 ◽  
Author(s):  
Minoru Maruyama ◽  
Natsu Hotta ◽  
Yasunori Nio ◽  
Kenichi Hamagami ◽  
Toshimi Nagi ◽  
...  
Keyword(s):  
Energy Homeostasis ◽  
Receptor Subtype ◽  
Neuronal Pathway ◽  
Bombesin Receptor ◽  
Subtype 3

scholarly journals Regulation of body temperature and brown adipose tissue thermogenesis by bombesin receptor subtype-3

2014 ◽  
Vol 306 (6) ◽  
pp. E681-E687 ◽  
Author(s):  
Dalya M. Lateef ◽  
Gustavo Abreu-Vieira ◽  
Cuiying Xiao ◽  
Marc L. Reitman
Keyword(s):  
Adipose Tissue ◽  
Body Temperature ◽  
Brown Adipose Tissue ◽  
Energy Homeostasis ◽  
Activity Level ◽  
Receptor Subtype ◽  
Reduced Body ◽  
Brown Adipose ◽  
Bombesin Receptor ◽  
Subtype 3

Bombesin receptor subtype-3 (BRS-3) regulates energy homeostasis, with Brs3 knockout ( Brs3−/y) mice being hypometabolic, hypothermic, and hyperphagic and developing obesity. We now report that the reduced body temperature is more readily detected if body temperature is analyzed as a function of physical activity level and light/dark phase. Physical activity level correlated best with body temperature 4 min later. The Brs3−/y metabolic phenotype is not due to intrinsically impaired brown adipose tissue function or in the communication of sympathetic signals from the brain to brown adipose tissue, since Brs3−/y mice have intact thermogenic responses to stress, acute cold exposure, and β3-adrenergic activation, and Brs3−/y mice prefer a cooler environment. Treatment with the BRS-3 agonist MK-5046 increased brown adipose tissue temperature and body temperature in wild-type but not Brs3−/y mice. Intrahypothalamic infusion of MK-5046 increased body temperature. These data indicate that the BRS-3 regulation of body temperature is via a central mechanism, upstream of sympathetic efferents. The reduced body temperature in Brs3−/y mice is due to altered regulation of energy homeostasis affecting higher center regulation of body temperature, rather than an intrinsic defect in brown adipose tissue.

scholarly journals Regulation of Energy Homeostasis by Bombesin Receptor Subtype-3: Selective Receptor Agonists for the Treatment of Obesity

2010 ◽  
Vol 11 (2) ◽  
pp. 101-112 ◽  
Author(s):  
Xiao-Ming Guan ◽  
Howard Chen ◽  
Peter H. Dobbelaar ◽  
Yan Dong ◽  
Tung M. Fong ◽  
...  
Keyword(s):  
Energy Homeostasis ◽  
Receptor Subtype ◽  
Receptor Agonists ◽  
Bombesin Receptor ◽  
Treatment Of Obesity ◽  
Subtype 3

scholarly journals Pharmacological characterization of a selective agonist for bombesin receptor subtype-3

2009 ◽  
Vol 387 (2) ◽  
pp. 283-288 ◽  
Author(s):  
Li Zhang ◽  
Hans-Peter Nothacker ◽  
Zhiwei Wang ◽  
Laura M. Bohn ◽  
Olivier Civelli
Keyword(s):  
Receptor Subtype ◽  
Pharmacological Characterization ◽  
Selective Agonist ◽  
Bombesin Receptor ◽  
Subtype 3

Su1544 The Molecular Basis for the High Affinity and Selectivity of the Peptide Antagonist, Bantag-1, for the Human Bombesin Receptor Subtype-3, hBRS-3

2016 ◽  
Vol 150 (4) ◽  
pp. S522
Author(s):  
Irene Ramos ◽  
Taichi Nakamura ◽  
Tatiana Iordanskaia ◽  
Paola Moreno ◽  
Samuel A. Mantey ◽  
...  
Keyword(s):  
Molecular Basis ◽  
Receptor Subtype ◽  
High Affinity ◽  
Bombesin Receptor ◽  
Peptide Antagonist ◽  
Subtype 3

scholarly journals Identification and functional characterization of hemorphins VV-H-7 and LVV-H-7 as low-affinity agonists for the orphan bombesin receptor subtype 3

2003 ◽  
Vol 138 (8) ◽  
pp. 1431-1440 ◽  
Author(s):  
Hans-Peter Lammerich ◽  
Annette Busmann ◽  
Christian Kutzleb ◽  
Martin Wendland ◽  
Petra Seiler ◽  
...  
Keyword(s):  
Functional Characterization ◽  
Receptor Subtype ◽  
Bombesin Receptor ◽  
Subtype 3

scholarly journals Rational Design of a Peptide Agonist That Interacts Selectively with the Orphan Receptor, Bombesin Receptor Subtype 3

2000 ◽  
Vol 276 (12) ◽  
pp. 9219-9229 ◽  
Author(s):  
Samuel A. Mantey ◽  
David H. Coy ◽  
Tapas K. Pradhan ◽  
Hisato Igarashi ◽  
Ivania M. Rizo ◽  
...  
Keyword(s):  
Rational Design ◽  
Orphan Receptor ◽  
Receptor Subtype ◽  
Bombesin Receptor ◽  
Peptide Agonist ◽  
Subtype 3

Investigation of the human bombesin receptor subtype-3 gene for the presence of mutations in obese individuals: A pilot study

2000 ◽  
Vol 118 (4) ◽  
pp. A852
Author(s):  
Gregory Ambra ◽  
Alessandro Doria ◽  
Haesook T. Kim ◽  
Horst C. Weber
Keyword(s):  
Pilot Study ◽  
Receptor Subtype ◽  
Bombesin Receptor ◽  
Subtype 3
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