scholarly journals Self-healing encapsulation and controlled release of vaccine antigens from PLGA microparticles delivered by microneedle patches

2018 ◽  
Vol 4 (1) ◽  
pp. 116-128 ◽  
Author(s):  
J. Maxwell Mazzara ◽  
Lukasz J. Ochyl ◽  
Justin K. Y. Hong ◽  
James J. Moon ◽  
Mark R. Prausnitz ◽  
...  
Keyword(s):  
Controlled Release ◽  
Self Healing ◽  
Vaccine Antigens ◽  
Plga Microparticles

Controlled Release of Insulin Granules from PLGA Microparticles for Glucose Modulation in Diabetes

Diabetes ◽  
2018 ◽  
Vol 67 (Supplement 1) ◽  
pp. 2279-PUB ◽  
Author(s):  
ROSITA PRIMAVERA ◽  
MIRKO MAGNONE ◽  
DANIELE DI MASCOLO ◽  
ELENA ZOCCHI ◽  
ANGELO DE PASCALE ◽  
...  
Keyword(s):  
Controlled Release ◽  
Insulin Granules ◽  
Plga Microparticles

Tannic complexes coated nanocontainers for controlled release of corrosion inhibitors in self-healing coatings

2019 ◽  
Vol 297 ◽  
pp. 1035-1041 ◽  
Author(s):  
Bei Qian ◽  
Marios Michailidis ◽  
Matt Bilton ◽  
Theo Hobson ◽  
Zhaoliang Zheng ◽  
...  
Keyword(s):  
Controlled Release ◽  
Corrosion Inhibitors ◽  
Self Healing

Controlled Release of Bone Growth Factors from Injectable, Biodegradable Polymer Scaffolds for Bone Tissue Engineering

2000 ◽  
Vol 662 ◽  
Author(s):  
Elizabeth L. Hedberg ◽  
Antonios G. Mikos
Keyword(s):  
Growth Factors ◽  
Controlled Release ◽  
Bone Growth ◽  
Bone Ingrowth ◽  
Release Kinetics ◽  
Salt Content ◽  
Burst Effect ◽  
Plga Microparticles ◽  
Model Drug

AbstractThe objective of this research is to fabricate injectable, polymeric composites that will act as scaffolds for bone ingrowth as well as carriers for the controlled release of bone growth factors. To that end, the injectable polyester poly(propylene fumarate) (PPF) was loaded with poly(DLlactic-co-glycolic acid) (PLGA) microparticles carrying the model drug FITC-dextran. This preparation was then crosslinked with N-vinyl pyrrolidinone in the presence of benzoyl peroxide as initiator and sodium chloride (NaCl) as leachable porogen. The encapsulation of growth factors in microparticles is necessary to minimize their denaturation during scaffold crosslinking. PLGA microparticles (0.04 g microparticles/g PPF) were incorporated into PPF composites having variable NaCl weight percents (50 and 70 wt% NaCl) and the effect on FITC-dextran release kinetics was determined in vitro for cylinders of diameter 6.5 mm and height 13.0 mm. The FITC-dextran loaded microparticles alone exhibited a large initial burst effect, while the composite materials displayed a smaller burst effect and a longer linear region of release. At day 3, 54.6±2.1%, 5.1±0.9%, and 12.5±0.3% of loaded FITC-dextran was released into pH 7.4 phosphate buffered saline from the microparticles, the 50 wt% NaCl, and the 70 wt% NaCl composites, respectively. By day 28, 90.9±6.9%, 12.7±1.7%, and 34.4±0.4% of loaded FITC-dextran was released. Our results demonstrate that PLGA microparticles can be incorporated into PPF composites and that the release kinetics of FITC-dextran can be systematically manipulated through alteration of the composite initial salt content.

scholarly journals Chemical and photochemical DNA “gears” reversibly control stiffness, shape-memory, self-healing and controlled release properties of polyacrylamide hydrogels

2019 ◽  
Vol 10 (4) ◽  
pp. 1008-1016 ◽  
Author(s):  
Xia Liu ◽  
Junji Zhang ◽  
Michael Fadeev ◽  
Ziyuan Li ◽  
Verena Wulf ◽  
...  
Keyword(s):  
Controlled Release ◽  
Shape Memory ◽  
Self Healing ◽  
Stimuli Responsive ◽  
Polyacrylamide Hydrogels

Stimuli-responsive polyacrylamide hydrogels crosslinked by glucosamine–boronate/G-quadruplexes or azobenzene-functionalized DNA reveal controlled stiffness using chemical or photochemical triggers.

Polyanionic self-healing hydrogels for the controlled release of cisplatin

2020 ◽  
Vol 133 ◽  
pp. 109773 ◽  
Author(s):  
Ye Tian ◽  
Yuan Zeng ◽  
Yongsan Li ◽  
Xianzhe He ◽  
Haibo Wu ◽  
...  
Keyword(s):  
Controlled Release ◽  
Self Healing

scholarly journals Gamma Irradiation of Active Self-Healing PLGA Microspheres for Efficient Aqueous Encapsulation of Vaccine Antigens

2013 ◽  
Vol 30 (7) ◽  
pp. 1768-1778 ◽  
Author(s):  
Kashappa-Goud H. Desai ◽  
Samer Kadous ◽  
Steven P. Schwendeman
Keyword(s):  
Gamma Irradiation ◽  
Self Healing ◽  
Plga Microspheres ◽  
Vaccine Antigens

A Stimuli-Responsive Supramolecular Hydrogel for Controlled Release of Drug

2017 ◽  
Vol 05 (03) ◽  
pp. 1750011 ◽  
Author(s):  
Subharanjan Biswas ◽  
Lakshmi Priya Datta ◽  
Soumyajit Roy
Keyword(s):  
Hydrogen Bonding ◽  
Controlled Release ◽  
Polyacrylic Acid ◽  
Dynamic Equilibrium ◽  
Guanidine Hydrochloride ◽  
Environmentally Benign ◽  
Self Healing ◽  
Stimuli Responsive ◽  
Interconnected Network ◽  
Supramolecular Hydrogel

An inexpensive, facile, and environmentally benign method has been developed for the preparation of stimuli-responsive and self-healing polyacrylic acid–chitosan-based supramolecular hydrogels. Guanidine hydrochloride is used as the supramolecular crosslinker to form an interconnected network with polyacrylic acid–chitosan complex. Because of the dynamic equilibrium between the hydrogen-bonding sites of the components, the hydrogels were found to be self-healable and sensitive to biochemical-stimulus, such as pH. Controlled loading of drug like doxorubicin and its significant anticancer activity of such hydrogels is worth mentioning.

scholarly journals Active self-healing encapsulation of vaccine antigens in PLGA microspheres

2013 ◽  
Vol 165 (1) ◽  
pp. 62-74 ◽  
Author(s):  
Kashappa-Goud H. Desai ◽  
Steven P. Schwendeman
Keyword(s):  
Self Healing ◽  
Plga Microspheres ◽  
Vaccine Antigens

Long-term controlled release of PLGA microparticles containing antidepressant mirtazapine

2014 ◽  
Vol 21 (2) ◽  
pp. 214-221 ◽  
Author(s):  
Jakub Vysloužil ◽  
Petr Doležel ◽  
Martina Kejdušová ◽  
Vratislav Košťál ◽  
Ludvík Beneš ◽  
...  
Keyword(s):  
Controlled Release ◽  
Plga Microparticles
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