Strategic assay deployment as a method for countering analytical bottlenecks in high throughput process development: Case studies in ion exchange chromatography

Exchange Chromatography

A high-throughput 2D-analytical technique to obtain single protein parameters from complex cell lysates for in silico process development of ion exchange chromatography

10.1016/j.chroma.2013.09.043 ◽

2013 ◽

Vol 1318 ◽

pp. 84-91 ◽

Cited By ~ 7

Author(s):

Frieder Kröner ◽

Dennis Elsäßer ◽

Jürgen Hubbuch

Keyword(s):

Ion Exchange ◽

High Throughput ◽

In Silico ◽

Process Development ◽

Exchange Chromatography ◽

Complex Cell ◽

Analytical Technique ◽

Cell Lysates ◽

Single Protein

Chromatography process development in the quality by design paradigm I: Establishing a high-throughput process development platform as a tool for estimating “characterization space” for an ion exchange chromatography step

Biotechnology Progress ◽

10.1002/btpr.1705 ◽

2013 ◽

Vol 29 (2) ◽

pp. 403-414 ◽

Cited By ~ 39

Author(s):

R. Bhambure ◽

A. S. Rathore

Keyword(s):

Ion Exchange ◽

High Throughput ◽

Quality By Design ◽

Process Development ◽

Exchange Chromatography ◽

Development Platform ◽

Design Paradigm ◽

Chromatography Step

High throughput process development for the purification of rapeseed proteins napin and cruciferin by ion exchange chromatography

Food and Bioproducts Processing ◽

10.1016/j.fbp.2020.11.011 ◽

2021 ◽

Vol 125 ◽

pp. 228-241

Author(s):

Mónica Moreno-González ◽

Pattra Chuekitkumchorn ◽

Marcelo Silva ◽

Roos Groenewoud ◽

Marcel Ottens

Keyword(s):

Ion Exchange ◽

High Throughput ◽

Process Development ◽

Exchange Chromatography ◽

Rapeseed Proteins

Micro-Plate Based Monolithic Ion-Exchange Chromatography for High Throughput Protein Purification Process Design

JOURNAL OF CHEMICAL ENGINEERING OF JAPAN ◽

10.1252/jcej.07we184 ◽

2008 ◽

Vol 41 (3) ◽

pp. 200-205 ◽

Cited By ~ 2

Author(s):

Noriko Yoshimoto ◽

Yuko Nishijima ◽

Parvin Akbarzadehlaleh ◽

Sachie Fujii ◽

Mitsuyo Abe ◽

...

Keyword(s):

Ion Exchange ◽

Protein Purification ◽

High Throughput ◽

Process Design ◽

Exchange Chromatography ◽

Purification Process

The hybrid experimental simplex algorithm – An alternative method for ‘sweet spot’ identification in early bioprocess development: Case studies in ion exchange chromatography

Analytica Chimica Acta ◽

10.1016/j.aca.2012.06.039 ◽

2012 ◽

Vol 743 ◽

pp. 19-32 ◽

Cited By ~ 9

Author(s):

Spyridon Konstantinidis ◽

Sunil Chhatre ◽

Ajoy Velayudhan ◽

Eva Heldin ◽

Nigel Titchener-Hooker

Keyword(s):

Ion Exchange ◽

Case Studies ◽

Simplex Algorithm ◽

Exchange Chromatography ◽

Sweet Spot ◽

Bioprocess Development ◽

Alternative Method

Hydrophilic modification gigaporous resins with poly(ethylenimine) for high-throughput proteins ion-exchange chromatography

10.1016/j.chroma.2014.03.064 ◽

2014 ◽

Vol 1343 ◽

pp. 109-118 ◽

Cited By ~ 19

Author(s):

Rongyue Zhang ◽

Qiang Li ◽

Yang Gao ◽

Juan Li ◽

Yongdong Huang ◽

...

Keyword(s):

Ion Exchange ◽

High Throughput ◽

Exchange Chromatography ◽

Hydrophilic Modification

Analytical characterization of complex, biotechnological feedstocks by pH gradient ion exchange chromatography for purification process development

10.1016/j.chroma.2013.08.034 ◽

2013 ◽

Vol 1311 ◽

pp. 55-64 ◽

Cited By ~ 16

Author(s):

Frieder Kröner ◽

Alexander T. Hanke ◽

Beckley K. Nfor ◽

Martijn W.H. Pinkse ◽

Peter D.E.M. Verhaert ◽

...

Keyword(s):

Ion Exchange ◽

Process Development ◽

Exchange Chromatography ◽

Ph Gradient ◽

Purification Process ◽

Analytical Characterization

An integrated precipitation and ion-exchange chromatography process for antibody manufacturing: Process development strategy and continuous chromatography exploration

10.1016/j.chroma.2017.12.013 ◽

2018 ◽

Vol 1533 ◽

pp. 66-76 ◽

Cited By ~ 14

Author(s):

Steffen Großhans ◽

Gang Wang ◽

Christian Fischer ◽

Jürgen Hubbuch

Keyword(s):

Ion Exchange ◽

Development Strategy ◽

Manufacturing Process ◽

Process Development ◽

Exchange Chromatography ◽

Continuous Chromatography

Scalable downstream process development for in vivo gene therapy products: understanding full/empty separation capabilities and challenges with ion exchange chromatography

Cell and Gene Therapy Insights ◽

10.18609/cgti.2021.132 ◽

2021 ◽

Vol 7 (8) ◽

pp. 1015-1021

Keyword(s):

Gene Therapy ◽

Ion Exchange ◽

Process Development ◽

Exchange Chromatography ◽

Downstream Process

Simultaneous HPTLC identification of Fig, Senna and P. hybridus using Ion Exchange Chromatography

10.1055/s-0037-1608200 ◽

2017 ◽

Author(s):

B Nägele ◽

J Wüthrich ◽

S Toff ◽

A Schenk

Keyword(s):

Ion Exchange ◽

Exchange Chromatography