scholarly journals Characterization of DNA damage response deficiency in pancreatic cancer patients from China

2021 ◽  
Author(s):  
Xiaofei Zhang ◽  
Tiebo Mao ◽  
Bei Zhang ◽  
Haiyan Xu ◽  
Jiujie Cui ◽  
...  
Keyword(s):  
Pancreatic Cancer ◽  
Dna Damage ◽  
Cancer Patients ◽  
Dna Damage Response ◽  
Damage Response

203. ATDC, A Novel DNA Damage Response Protein, Is Highly Expressed in Pancreatic Cancer

2008 ◽  
Vol 144 (2) ◽  
pp. 267-268
Author(s):  
Dawn Barnes ◽  
Lidong Wang ◽  
Mats Ljungman ◽  
Diane Simeone
Keyword(s):  
Pancreatic Cancer ◽  
Dna Damage ◽  
Dna Damage Response ◽  
Damage Response

DNA damage response and repair in pancreatic cancer development and therapy

DNA Repair ◽  
2021 ◽  
pp. 103116
Author(s):  
Parnia Rahnamay Farnood ◽  
Romina Danesh Pazhooh ◽  
Zatollah Asemi ◽  
Bahman Yousefi
Keyword(s):  
Pancreatic Cancer ◽  
Dna Damage ◽  
Dna Damage Response ◽  
Cancer Development ◽  
Damage Response

scholarly journals In Vitro Biological Characterization of DCUN1D5 in DNA Damage Response

2012 ◽  
Vol 13 (8) ◽  
pp. 4157-4162 ◽  
Author(s):  
Wei Guo ◽  
Guo-Jun Li ◽  
Hong-Bo Xu ◽  
Jie-Shi Xie ◽  
Tai-Ping Shi ◽  
...  
Keyword(s):  
Dna Damage ◽  
Dna Damage Response ◽  
Biological Characterization ◽  
Damage Response

scholarly journals APE2 Is a General Regulator of the ATR-Chk1 DNA Damage Response Pathway to Maintain Genome Integrity in Pancreatic Cancer Cells

2021 ◽  
Vol 9 ◽  
Author(s):  
Md Akram Hossain ◽  
Yunfeng Lin ◽  
Garrett Driscoll ◽  
Jia Li ◽  
Anne McMahon ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Pancreatic Cancer ◽  
Dna Damage ◽  
Cancer Cells ◽  
Dna Damage Response ◽  
Human Pancreatic Cancer ◽  
Genome Integrity ◽  
Pancreatic Cancer Cells ◽  
Damage Response ◽  
Egg Extracts

The maintenance of genome integrity and fidelity is vital for the proper function and survival of all organisms. Recent studies have revealed that APE2 is required to activate an ATR-Chk1 DNA damage response (DDR) pathway in response to oxidative stress and a defined DNA single-strand break (SSB) in Xenopus laevis egg extracts. However, it remains unclear whether APE2 is a general regulator of the DDR pathway in mammalian cells. Here, we provide evidence using human pancreatic cancer cells that APE2 is essential for ATR DDR pathway activation in response to different stressful conditions including oxidative stress, DNA replication stress, and DNA double-strand breaks. Fluorescence microscopy analysis shows that APE2-knockdown (KD) leads to enhanced γH2AX foci and increased micronuclei formation. In addition, we identified a small molecule compound Celastrol as an APE2 inhibitor that specifically compromises the binding of APE2 but not RPA to ssDNA and 3′-5′ exonuclease activity of APE2 but not APE1. The impairment of ATR-Chk1 DDR pathway by Celastrol in Xenopus egg extracts and human pancreatic cancer cells highlights the physiological significance of Celastrol in the regulation of APE2 functionalities in genome integrity. Notably, cell viability assays demonstrate that APE2-KD or Celastrol sensitizes pancreatic cancer cells to chemotherapy drugs. Overall, we propose APE2 as a general regulator for the DDR pathway in genome integrity maintenance.

Actionable perturbations in the DNA damage response establish synergistic therapeutic routes in ATM deficient pancreatic cancer

Pancreatology ◽  
2018 ◽  
Vol 18 (4) ◽  
pp. S74
Author(s):  
Johann Gout ◽  
Lukas Perkhofer ◽  
Frank Arnold ◽  
Thomas Seufferlein ◽  
Pierre-Oliver Frappart ◽  
...  
Keyword(s):  
Pancreatic Cancer ◽  
Dna Damage ◽  
Dna Damage Response ◽  
Damage Response

scholarly journals Early Detection in a Mouse Model of Pancreatic Cancer by Imaging DNA Damage Response Signaling

2019 ◽  
Vol 61 (7) ◽  
pp. 1006-1013
Author(s):  
James C. Knight ◽  
Julia Baguña Torres ◽  
Robert Goldin ◽  
Michael Mosley ◽  
Gemma M. Dias ◽  
...  
Keyword(s):  
Pancreatic Cancer ◽  
Dna Damage ◽  
Early Detection ◽  
Mouse Model ◽  
Dna Damage Response ◽  
Damage Response

Abstract 1740: Characterization of CDK9 role in the DNA damage response

2019 ◽  
Author(s):  
Thales C. Nepomuceno ◽  
Guilherme Suarez-Kurtz ◽  
Alvaro N. Monteiro ◽  
Marcelo A. Carvalho
Keyword(s):  
Dna Damage ◽  
Dna Damage Response ◽  
Damage Response
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