Terpenoids-enriched fraction of Celastrus orbiculatus sensitizes gemcitabine by disrupting Chk1/RAD51-mediated DNA damage response in pancreatic cancer

2021 ◽  
Author(s):  
Yang Zhao ◽  
Zhuangzhuang Jiang ◽  
Tengyang Ni ◽  
Wei Jiang ◽  
Kehui Zhou ◽  
...  
Keyword(s):  
Pancreatic Cancer ◽  
Dna Damage ◽  
Dna Damage Response ◽  
Celastrus Orbiculatus ◽  
Damage Response

203. ATDC, A Novel DNA Damage Response Protein, Is Highly Expressed in Pancreatic Cancer

2008 ◽  
Vol 144 (2) ◽  
pp. 267-268
Author(s):  
Dawn Barnes ◽  
Lidong Wang ◽  
Mats Ljungman ◽  
Diane Simeone
Keyword(s):  
Pancreatic Cancer ◽  
Dna Damage ◽  
Dna Damage Response ◽  
Damage Response

DNA damage response and repair in pancreatic cancer development and therapy

DNA Repair ◽  
2021 ◽  
pp. 103116
Author(s):  
Parnia Rahnamay Farnood ◽  
Romina Danesh Pazhooh ◽  
Zatollah Asemi ◽  
Bahman Yousefi
Keyword(s):  
Pancreatic Cancer ◽  
Dna Damage ◽  
Dna Damage Response ◽  
Cancer Development ◽  
Damage Response

scholarly journals APE2 Is a General Regulator of the ATR-Chk1 DNA Damage Response Pathway to Maintain Genome Integrity in Pancreatic Cancer Cells

2021 ◽  
Vol 9 ◽  
Author(s):  
Md Akram Hossain ◽  
Yunfeng Lin ◽  
Garrett Driscoll ◽  
Jia Li ◽  
Anne McMahon ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Pancreatic Cancer ◽  
Dna Damage ◽  
Cancer Cells ◽  
Dna Damage Response ◽  
Human Pancreatic Cancer ◽  
Genome Integrity ◽  
Pancreatic Cancer Cells ◽  
Damage Response ◽  
Egg Extracts

The maintenance of genome integrity and fidelity is vital for the proper function and survival of all organisms. Recent studies have revealed that APE2 is required to activate an ATR-Chk1 DNA damage response (DDR) pathway in response to oxidative stress and a defined DNA single-strand break (SSB) in Xenopus laevis egg extracts. However, it remains unclear whether APE2 is a general regulator of the DDR pathway in mammalian cells. Here, we provide evidence using human pancreatic cancer cells that APE2 is essential for ATR DDR pathway activation in response to different stressful conditions including oxidative stress, DNA replication stress, and DNA double-strand breaks. Fluorescence microscopy analysis shows that APE2-knockdown (KD) leads to enhanced γH2AX foci and increased micronuclei formation. In addition, we identified a small molecule compound Celastrol as an APE2 inhibitor that specifically compromises the binding of APE2 but not RPA to ssDNA and 3′-5′ exonuclease activity of APE2 but not APE1. The impairment of ATR-Chk1 DDR pathway by Celastrol in Xenopus egg extracts and human pancreatic cancer cells highlights the physiological significance of Celastrol in the regulation of APE2 functionalities in genome integrity. Notably, cell viability assays demonstrate that APE2-KD or Celastrol sensitizes pancreatic cancer cells to chemotherapy drugs. Overall, we propose APE2 as a general regulator for the DDR pathway in genome integrity maintenance.

Actionable perturbations in the DNA damage response establish synergistic therapeutic routes in ATM deficient pancreatic cancer

Pancreatology ◽  
2018 ◽  
Vol 18 (4) ◽  
pp. S74
Author(s):  
Johann Gout ◽  
Lukas Perkhofer ◽  
Frank Arnold ◽  
Thomas Seufferlein ◽  
Pierre-Oliver Frappart ◽  
...  
Keyword(s):  
Pancreatic Cancer ◽  
Dna Damage ◽  
Dna Damage Response ◽  
Damage Response

scholarly journals Early Detection in a Mouse Model of Pancreatic Cancer by Imaging DNA Damage Response Signaling

2019 ◽  
Vol 61 (7) ◽  
pp. 1006-1013
Author(s):  
James C. Knight ◽  
Julia Baguña Torres ◽  
Robert Goldin ◽  
Michael Mosley ◽  
Gemma M. Dias ◽  
...  
Keyword(s):  
Pancreatic Cancer ◽  
Dna Damage ◽  
Early Detection ◽  
Mouse Model ◽  
Dna Damage Response ◽  
Damage Response

scholarly journals Characterization of DNA damage response deficiency in pancreatic cancer patients from China

2021 ◽  
Author(s):  
Xiaofei Zhang ◽  
Tiebo Mao ◽  
Bei Zhang ◽  
Haiyan Xu ◽  
Jiujie Cui ◽  
...  
Keyword(s):  
Pancreatic Cancer ◽  
Dna Damage ◽  
Cancer Patients ◽  
Dna Damage Response ◽  
Damage Response

scholarly journals Targeting DNA Damage Response and Replication Stress in Pancreatic Cancer

2021 ◽  
Vol 160 (1) ◽  
pp. 362-377.e13 ◽  
Author(s):  
Stephan B. Dreyer ◽  
Rosie Upstill-Goddard ◽  
Viola Paulus-Hock ◽  
Clara Paris ◽  
Eirini-Maria Lampraki ◽  
...  
Keyword(s):  
Pancreatic Cancer ◽  
Dna Damage ◽  
Dna Damage Response ◽  
Replication Stress ◽  
Damage Response

Abstract A18: HuR, an RNA binding protein, is critical for the DNA damage response in pancreatic cancer cells.

2012 ◽  
Author(s):  
Shruti Lal ◽  
Vikram Bhattacharjee ◽  
Timothy Yen ◽  
Richard A. Burkhart ◽  
Danielle M. Pineda ◽  
...  
Keyword(s):  
Pancreatic Cancer ◽  
Dna Damage ◽  
Cancer Cells ◽  
Dna Damage Response ◽  
Rna Binding ◽  
Binding Protein ◽  
Rna Binding Protein ◽  
Pancreatic Cancer Cells ◽  
Damage Response

CD147 promotes DNA damage response and gemcitabine resistance via targeting ATM/ATR/p53 and affects prognosis in pancreatic cancer

2020 ◽  
Vol 528 (1) ◽  
pp. 62-70 ◽  
Author(s):  
Yinghui Zhou ◽  
Ming Zheng ◽  
Zhenyu Liu ◽  
Haijiao Yang ◽  
Ping Zhu ◽  
...  
Keyword(s):  
Pancreatic Cancer ◽  
Dna Damage ◽  
Dna Damage Response ◽  
Gemcitabine Resistance ◽  
Damage Response

scholarly journals Low CHD5 expression activates the DNA damage response and predicts poor outcome in patients undergoing adjuvant therapy for resected pancreatic cancer

Oncogene ◽  
2013 ◽  
Vol 33 (47) ◽  
pp. 5450-5456 ◽  
Author(s):  
W A Hall ◽  
A V Petrova ◽  
L E Colbert ◽  
C W Hardy ◽  
S B Fisher ◽  
...  
Keyword(s):  
Pancreatic Cancer ◽  
Dna Damage ◽  
Adjuvant Therapy ◽  
Dna Damage Response ◽  
Poor Outcome ◽  
Damage Response
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