Trypanocidal Activity of Dysphania ambrosioides , Lippia alba , and Tetradenia riparia Essential Oils against Trypanosoma cruzi

2021 ◽  
Author(s):  
Antônio E. M. Crotti ◽  
Mariana C. Pagotti ◽  
Ana C. B. B. Candido ◽  
Maria G. Marçal ◽  
Tatiana M. Vieira ◽  
...  
Keyword(s):  
Trypanosoma Cruzi ◽  
Essential Oils ◽  
Trypanocidal Activity ◽  
Lippia Alba

scholarly journals Chemical Composition and Anti-Trypanosoma cruzi Activity of Essential Oils Obtained from Leaves of Xylopia frutescens and X. laevigata (Annonaceae)

2013 ◽  
Vol 8 (3) ◽  
pp. 1934578X1300800 ◽  
Author(s):  
Thanany Brasil da Silva ◽  
Leociley Rocha Alencar Menezes ◽  
Marília Fernanda Chaves Sampaio ◽  
Cássio Santana Meira ◽  
Elisalva Teixeira Guimarães ◽  
...  
Keyword(s):  
Chemical Composition ◽  
Trypanosoma Cruzi ◽  
Essential Oils ◽  
Trypanocidal Activity ◽  
Germacrene D ◽  
Main Components ◽  
Type Apparatus

Essential oils from leaves of Xylopia frutescens (XFMJ) and two specimens of Xylopia laevigata (XLMC and XLSI) were obtained by hydrodistillation using a Clevenger-type apparatus, and analyzed by GC-MS and GC-FID. Sesquiterpenes dominated the essential oils. The main constituents of XFMJ were ( E)-caryophyllene (24.8%), bicyclogermacrene (20.8%), germacrene D (17.0%), β-elemene (7.9%), and ( E)-β-ocimene (6.8%). XLMC contained significant quantities of germacrene D (18.9%), bicyclogermacrene (18.4%), β-elemene (9.5%), 5-selinene (9.2%), ( E)-caryophyllene (8.5%), germacrene B (5.7%) and γ-muurolene (5.7%), while germacrene D (27.0%), bicyclogermacrene (12.8%), ( E)-caryophyllene (8.6%), γ-muurolene (8.6%), 5-cadinene (6.8%), and germacrene B (6.0%) were the main components of XLSI. The essential oils had trypanocidal activity against the Y strain of Trypanosoma cruzi. with IC50 values lower than 30 μg.mL−1 and 15 μg.mL−1 against epimastigote and trypomastigote forms of T. cruzi. respectively, and were also able to reduce the percentage in vitro of T. cruzi-infected macrophages and the intracellular number of amastigotes at concentrations that were non-cytotoxic to macrophages.

scholarly journals Immunomodulation and Antioxidant Activities as Possible Trypanocidal and Cardioprotective Mechanisms of Major Terpenes from Lippia alba Essential Oils in an Experimental Model of Chronic Chagas Disease

Antioxidants ◽  
2021 ◽  
Vol 10 (11) ◽  
pp. 1851
Author(s):  
Denerieth Ximena Espinel-Mesa ◽  
Clara Isabel González Rugeles ◽  
Julio César Mantilla Hernández ◽  
Elena E. Stashenko ◽  
Carlos Andrés Villegas-Lanau ◽  
...  
Keyword(s):  
Essential Oils ◽  
Chagas Disease ◽  
Antioxidant Activities ◽  
Combined Therapy ◽  
Late Phase ◽  
Immunomodulatory Activity ◽  
Caryophyllene Oxide ◽  
Cardiac Damage ◽  
Lippia Alba ◽  
Chronic Chagas Disease

In the late phase of Trypanosoma cruzi infection, parasite persistence and an exaggerated immune response accompanied by oxidative stress play a crucial role in the genesis of Chronic Chagasic Cardiomyopathy (CCC). Current treatments (Benznidazole (BNZ) and Nifurtimox) can effect only the elimination of the parasite, but are ineffective for late stage treatment and for preventing heart damage and disease progression. In vivo trypanocidal and cardioprotective activity has been reported for Lippia alba essential oils (EOs), ascribed to their two major terpenes, limonene and caryophyllene oxide. To investigate the role of antioxidant and immunomodulatory mechanisms behind these properties, chronic-T. cruzi-infected rats were treated with oral synergistic mixtures of the aforementioned EOs. For this purpose, the EOs were optimized through limonene-enrichment fractioning and by the addition of exogenous caryophyllene oxide (LIMOX) and used alone or in combined therapy with subtherapeutic doses of BNZ (LIMOXBNZ). Clinical, toxicity, inflammatory, oxidative, and parasitological (qPCR) parameters were assessed in cardiac tissue. These therapies demonstrated meaningful antioxidant and immunomodulatory activity on markers involved in CCC pathogenesis (IFN-γ, TNF-α, IL-4, IL-10, and iNOS), which could explain their significant trypanocidal properties and their noteworthy role in preventing, and even reversing, the progression of cardiac damage in chronic Chagas disease.

Antimicrobial and synergistic activity of essential oils of Aloysia triphylla and Lippia alba against Aeromonas spp.

2017 ◽  
Vol 113 ◽  
pp. 29-33 ◽  
Author(s):  
Renilde Cordeiro de Souza ◽  
Mateus Matiuzzi da Costa ◽  
Bernardo Baldisserotto ◽  
Berta Maria Heinzmann ◽  
Denise Schmidt ◽  
...  
Keyword(s):  
Essential Oils ◽  
Synergistic Activity ◽  
Lippia Alba ◽  
Aloysia Triphylla

Differential anti-proliferative effect on K562 leukemia cells of Lippia alba (Verbenaceae) essential oils produced under diverse growing, collection and extraction conditions

2017 ◽  
Vol 96 ◽  
pp. 140-148 ◽  
Author(s):  
Liliana Torcoroma García ◽  
Andrés Felipe Leal ◽  
Érika Marcela Moreno ◽  
Elena E. Stashenko ◽  
H. José Arteaga
Keyword(s):  
Essential Oils ◽  
Leukemia Cells ◽  
Lippia Alba ◽  
Proliferative Effect

Ocimum americanum and Lippia alba essential oils as anaesthetics for Nile tilapia: Induction, recovery of apparent unconsciousness and sensory analysis of fillets

Aquaculture ◽  
2021 ◽  
Vol 531 ◽  
pp. 735902
Author(s):  
Daniel Santiago Rucinque ◽  
Pedro Fontalva Ferreira ◽  
Paulo Roberto Pedroso Leme ◽  
Judite Lapa-Guimarães ◽  
Elisabete Maria Macedo Viegas
Keyword(s):  
Essential Oils ◽  
Sensory Analysis ◽  
Nile Tilapia ◽  
Lippia Alba ◽  
Ocimum Americanum

scholarly journals Use of Dimethyldioxirane in the Epoxidation of the Main Constituents of the Essential Oils Obtained from Tagetes Lucida, Cymbopogon Citratus, Lippia Alba and Eucalyptus citriodora

2011 ◽  
Vol 6 (7) ◽  
pp. 1934578X1100600 ◽  
Author(s):  
Luz A. Veloza ◽  
Lina M. Orozco ◽  
Juan C. Sepúlveda-Arias
Keyword(s):  
Essential Oils ◽  
Organic Synthesis ◽  
Oxygen Transfer ◽  
Environmentally Friendly ◽  
Acetone Solution ◽  
Oxidation Reactions ◽  
Eucalyptus Citriodora ◽  
Cymbopogon Citratus ◽  
Lippia Alba

Dimethyldioxirane (DMDO), a widely used oxidant in organic synthesis is considered an environmentally friendly oxygen transfer reagent because acetone is the only byproduct formed in its oxidation reactions. This work describes the isolation of the main constituents (terpenes) in the essential oils obtained from Tagetes lucida, Cymbopogon citratus, Lippia alba and Eucalyptus citriodora, their epoxidation with DMDO in acetone solution and the characterization of the resulting epoxides by GC-MS (EI) and NMR. This is one of the first reports involving the application of dioxirane chemistry to essential oils in order to generate modified compounds with potential uses in several areas of medicine and industry.

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