Anti‐HIV compounds from the deep‐sea‐derived fungus Chaetomium globosum

Chaetoglobosins belonging to cytochalasan alkaloids represent a large class of fungal secondary metabolites. To date, around 100 chaetoglobosins and their analogues have been isolated and identified over the years from a variety of fungi, mainly from the fungus Chaetomium globosum. Studies have found that chaetoglobosins possess a broad range of biological activities, including antitumor, antifungal, phytotoxic, fibrinolytic, antibacterial, nematicidal, anti-inflammatory, and anti-HIV activities. This review will comprehensively summarize the biological activities and mechanisms of action of nature-derived chaetoglobosins.

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ChemInform Abstract: Armochaetoglobins K-R, anti-HIV Pyrrole-Based Cytochalasans from Chaetomium globosum TW1-1.

ChemInform ◽

10.1002/chin.201538214 ◽

2015 ◽

Vol 46 (38) ◽

pp. no-no

Author(s):

Yongbo Xue ◽

et al.

Keyword(s):

Chaetomium Globosum ◽

Anti Hiv

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New Glutamine-Containing Azaphilone Alkaloids from Deep-Sea-Derived Fungus Chaetomium globosum HDN151398

Marine Drugs ◽

10.3390/md17050253 ◽

2019 ◽

Vol 17 (5) ◽

pp. 253 ◽

Cited By ~ 7

Author(s):

Chunxiao Sun ◽

Xueping Ge ◽

Shah Mudassir ◽

Luning Zhou ◽

Guihong Yu ◽

...

Keyword(s):

Amino Acids ◽

Deep Sea ◽

Human Cancer ◽

Structural Diversity ◽

2D Nmr ◽

Chaetomium Globosum ◽

Deep Sea Sediment ◽

Human Cancer Cell Lines ◽

Incubation Experiments ◽

Related Compounds

Three new azaphilone alkaloids containing glutamine residues, namely N-glutarylchaetoviridins A–C (1–3), together with two related compounds (4 and 5) were isolated from the extract of Chaetomium globosum HDN151398, a fungus isolated from a deep-sea sediment sample collected in South China Sea. Their structures were elucidated on the basis of extensive 1D and 2D NMR as well as HRESIMS spectroscopic data and chemical analysis. N-glutarylchaetoviridins A–C (1–3) represent the first class of chaetoviridins characterized by embedded glutamate residues. Amino acids incubation experiments produced five azaphilone laden different amino acids residues (6–10) which indicated that this method can enhanced the structural diversity of this strain by culturing with amino acids. Cytotoxicity of the isolated compounds were evaluated against a panel of human cancer cell lines.

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