TNF-α and leptin in experimental liver fibrosis models induced by carbon tetrachloride and by common bile duct ligation

2004 ◽  
Vol 22 (6) ◽  
pp. 359-363 ◽  
Author(s):  
İbrahim Halil Bahçecıoğlu ◽  
Mehmet Yalniz ◽  
Hüseyin Ataseven ◽  
Nurullah Bülbüller ◽  
Muzaffer Keçecı ◽  
...  
Keyword(s):  
Carbon Tetrachloride ◽  
Bile Duct ◽  
Liver Fibrosis ◽  
Common Bile Duct ◽  
Bile Duct Ligation ◽  
Common Bile Duct Ligation ◽  
Duct Ligation ◽  
Tnf Α ◽  
Experimental Liver

Kinetics of Pulmonary Angiogenesis in Mouse Common Bile Duct Ligation-Induced Liver Fibrosis

2016 ◽  
Vol 64 (2) ◽  
pp. S451
Author(s):  
S. Raevens ◽  
L. Devisscher ◽  
A. Paridaens ◽  
E. Bogaerts ◽  
S. Lefere ◽  
...  
Keyword(s):  
Bile Duct ◽  
Liver Fibrosis ◽  
Common Bile Duct ◽  
Bile Duct Ligation ◽  
Common Bile Duct Ligation ◽  
Duct Ligation ◽  
Kinetics Of

Effect of sensory denervation with capsaicin on liver fibrosis induced by common bile duct ligation in rat

1990 ◽  
Vol 11 (3) ◽  
pp. 302-312 ◽  
Author(s):  
Alessandro Casini ◽  
Irmgard Th. Lippe ◽  
Stefano Evangelista ◽  
Pierangelo Geppetti ◽  
Paolo Santicioli ◽  
...  
Keyword(s):  
Bile Duct ◽  
Liver Fibrosis ◽  
Common Bile Duct ◽  
Bile Duct Ligation ◽  
Common Bile Duct Ligation ◽  
Duct Ligation ◽  
Sensory Denervation

scholarly journals Pathophysiology of Lung Injury Induced by Common Bile Duct Ligation in Mice

PLoS ONE ◽  
2014 ◽  
Vol 9 (4) ◽  
pp. e94550 ◽  
Author(s):  
Fumiaki Shikata ◽  
Tomohisa Sakaue ◽  
Koh-ichi Nakashiro ◽  
Mikio Okazaki ◽  
Mie Kurata ◽  
...  
Keyword(s):  
Bile Duct ◽  
Common Bile Duct ◽  
Lung Injury ◽  
Bile Duct Ligation ◽  
Common Bile Duct Ligation ◽  
Duct Ligation

scholarly journals A new model of reversible obstructive jaundice using rapidly absorbable suture materials

2012 ◽  
Vol 35 (6) ◽  
pp. 351 ◽  
Author(s):  
Nurettin Kahramansoy ◽  
Hayri Erkol ◽  
Edip E Yilmaz ◽  
Mustafa Şit ◽  
Fahri Yilmaz ◽  
...  
Keyword(s):  
Bile Duct ◽  
Common Bile Duct ◽  
Obstructive Jaundice ◽  
Surgical Intervention ◽  
Bile Duct Ligation ◽  
Absorbable Suture ◽  
Suture Materials ◽  
Common Bile Duct Ligation ◽  
Duct Ligation ◽  
Morphologic Changes

Purpose: Reversible obstructive jaundice models have some limiting features, including the need for a second anaesthesia, re-laparotomy and surgical intervention after common bile duct ligation. The present study investigates the feasibility of a new application that can eliminate these limitations. Rapidly absorbable suture materials were used for ligation; therefore, spontaneous biliary decompression was anticipated by the self release of these rapidly degrading materials. Methods: Common bile ducts in Wistar Albino rats were ligated with silk, polyglytone 6211, or irradiated polyglactine 910 (n=7 for each group). Rats were grouped according to both the suture materials and the experiments termination date: 5 days (sham, silk5, polyglytone5, polyglactine5) and 21 days (silk21, polyglytone21, polyglactine21) after the ligation. Biochemical and morphologic changes of liver were assessed. Results: The group polyglactine21 showed significantly lower mean ALT, AST, GGT, total and direct bilirubin values when compared with the group polyglactine5 (p=0.004-0.037). Morphologic changes did not correlate with the biochemical amelioration. In the group polyglytone21, not only the biochemical but also the morphologic changes significantly ameliorated when compared with the group polyglytone5 (p=0.003-0.043). No procedure associated mortality was observed. Conclusion: Common bile duct ligation with polyglytone offers a new reversible model for prolonged obstructive jaundice which abolishes the need for relaparotomy and a second surgical intervention and significantly reduces mortality.

scholarly journals Review of experimental models for inducing hepatic cirrhosis by bile duct ligation and carbon tetrachloride injection

2012 ◽  
Vol 27 (8) ◽  
pp. 589-594 ◽  
Author(s):  
Thamirys Guimarães Marques ◽  
Eleazar Chaib ◽  
Juliana Hamati da Fonseca ◽  
Ana Cecília Rodrigues Lourenço ◽  
Felipe Duarte Silva ◽  
...  
Keyword(s):  
Liver Cirrhosis ◽  
Carbon Tetrachloride ◽  
Bile Duct ◽  
Web Sites ◽  
Bile Duct Ligation ◽  
Experimental Models ◽  
Duct Ligation ◽  
Experimental Liver Cirrhosis ◽  
Experimental Liver ◽  
Better Than

PURPOSE: To present a review about a comparative study of bile duct ligation versus carbon tetrachloride Injection for inducing experimental liver cirrhosis. METHODS: This research was made through Medline/PubMed and SciELO web sites looking for papers on the content "induction of liver cirrhosis in rats". We have found 107 articles but only 30 were selected from 2004 to 2011. RESULTS: The most common methods used for inducing liver cirrhosis in the rat were administration of carbon tetrachloride (CCl4) and bile duct ligation (BDL). CCl4 has induced cirrhosis from 36 hours to 18 weeks after injection and BDL from seven days to four weeks after surgery. CONCLUSION: For a safer inducing cirrhosis method BDL is better than CCl4 because of the absence of toxicity for researches and shorter time for achieving it.

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