Antidiabetic effects of quercetin and liraglutide combination through modulation of TXNIP / IRS ‐1/ PI3K pathway

2021 ◽  
Author(s):  
Salma M. Eraky ◽  
Nehal M. Ramadan ◽  
Nada F. Abo El‐Magd
Keyword(s):  
Pi3k Pathway ◽  
Antidiabetic Effects

Antidiabetic effects of Allium ascalonicum methanolic extract in experimental diabetes

Planta Medica ◽  
2011 ◽  
Vol 77 (12) ◽  
Author(s):  
S Montasser Kouhsari ◽  
M Fehresty Sani
Keyword(s):  
Methanolic Extract ◽  
Experimental Diabetes ◽  
Antidiabetic Effects

THE ROLE OF PHOSPHATIDYLINOSITOL-3-KINASE IN CARCINOGENESIS

2017 ◽  
Vol 63 (4) ◽  
pp. 545-556
Author(s):  
Natalya Oskina ◽  
Aleksandr Shcherbakov ◽  
Maksim Filipenko ◽  
Nikolay Kushlinskiy ◽  
L. Ovchinnikova
Keyword(s):  
Genetic Disease ◽  
Intracellular Signaling ◽  
Somatic Mutations ◽  
Pi3k Pathway ◽  
Genetic Alterations ◽  
Phosphatidylinositol 3 Kinase ◽  
Intracellular Signaling Pathway ◽  
Metabolic Activities ◽  
Carcinogenic Process

Currently it is established that cancer is a genetic disease and that somatic mutations are the initiators of the carcinogenic process. The PI3K/AKT/mTOR pathway is an important intracellular signaling pathway regulating the cell growth and metabolic activities. Aberrant activation of the PI3K pathway is commonly observed in many different cancers. In this review we analyze the genetic alterations of PI3K pathway in a variety of human malignancies and discuss their possible implications for diagnosis and therapy.

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