Blood flow velocity in donor coronary artery depends on the degree and pattern of collateral vessel development: A study using thrombolysis in myocardial infarction frame count method

2003 ◽  
Vol 60 (4) ◽  
pp. 462-468 ◽  
Author(s):  
Plamen Gatzov ◽  
Athanassios Manginas ◽  
Vassilis Voudris ◽  
Gregory Pavlides ◽  
Gencho D. Genchev ◽  
...  

Circulation ◽  
1996 ◽  
Vol 94 (6) ◽  
pp. 1269-1275 ◽  
Author(s):  
Katsuomi Iwakura ◽  
Hiroshi Ito ◽  
Shin Takiuchi ◽  
Yoshiaki Taniyama ◽  
Yoshiaki Nakatsuchi ◽  
...  


2003 ◽  
Vol 285 (5) ◽  
pp. H2194-H2200 ◽  
Author(s):  
Steven A. J. Chamuleau ◽  
Maria Siebes ◽  
Martijn Meuwissen ◽  
Karel T. Koch ◽  
Jos A. E. Spaan ◽  
...  

Homogeneity of microvascular resistance in different perfusion areas of the same heart is generally assumed. We investigated the effect of the severity of an epicardial stenosis on microvascular resistance in 27 patients with coronary artery disease and stable angina. All patients had an angiographically normal coronary artery, an artery with an intermediate lesion, and an artery with a severe lesion; the latter was treated with angioplasty. In each patient, distal blood flow velocity and pressure were measured during baseline and maximal hyperemia (induced by intracoronary adenosine) using a Doppler and pressure guide wire, respectively. The ratio of mean distal pressure to average peak blood flow velocity was used as an index for the microvascular resistance (MRv). Within patients, the hyperemic MRv was higher in arteries with more severe stenosis ( P = 0.021). After percutaneous transluminal coronary angioplasty (PTCA), the hyperemic MRv decreased (pre-PTCA, 2.6 vs. post-PTCA, 1.9 mmHg·cm–1s–1, P < 0.01) toward the value of the reference artery (1.7 mmHg·cm–1s–1; P = 0.67). We conclude that there is a positive association between coronary lesion severity and variability of distal microvascular resistance that normalizes after angioplasty. This study challenges the concept of uniform distribution of hyperemic MRv that is relevant for the interpretation of both noninvasive and invasive diagnostic tests.





Angiology ◽  
2001 ◽  
Vol 52 (8) ◽  
pp. 527-532
Author(s):  
Niyazi Güler ◽  
Beyhan Eryonucu ◽  
Mehmet Bilge ◽  
Ömer Etlik ◽  
Reha Erkoç ◽  
...  


2021 ◽  
Author(s):  
Wenbin Lu ◽  
Xiaoguo Zhang ◽  
Dong Wang ◽  
Genshan Ma ◽  
Lijuan Chen ◽  
...  

Abstract Quantitative Flow Ratio (QFR) is now a new method for the assessment of the extent of coronary artery stenosis but may be obscured by involvement of the mutated status of anatomical structure and blood flow in the coronary artery when encountering Atrial Fibrillation (AF). In this study, we aimed to expose the effect of mutated status of anatomical structure and blood flow on QFR results in AF patients. Methods and results: We evaluated QFR on 223 patients (112 patients with AF; 111non-AF patients served as control) who had undergone PCI-ES due to severe stenoses in coronary arteries. QFR of the target coronary was determined according to the flow rate of the contrast agent, results showed that AF patients with significantly higher QFR value than control group (0.792 ± 0.011 vs. 0.685 ± 0.016, p<0.001). Then we further analyzed the local QFR around the stenoses (0.858 ± 0.0287 vs. 0.756 ± 0.014, p=0.002), residual QFR (0.958 ± 0.005 vs. 0.929 ± 0.009, p=0.005), index QFR (0.807 ± 0.010vs. 0.713 ± 0.014, p<0.0001) in these two groups of patients with and without AF. Further analysis revealed that AF patients accompanied with relatively lower blood flow velocity (0.130 ± 0.006 m/s vs. 0.153 ± 0.005 m/s, p=0.003) in the diseased coronary artery as compared to the control. Meanwhile we observed that AF patients with higher minimum lumen area (MLA, mm2) (1.65 ± 0.097 vs. 1.11 ± 0.062, p<0.001) and decreased maximum lesion distorted angle (28.14°± 1.16°vs. 31.95°± 1.23°, p=0.025) compared to the control.Conclusion: Mutated status of anatomical structure and blood flow in the coronary artery of AF patients may enlarge the value of QFR, this may be ascribed to the lower blood flow velocity and decreased maximum lesion distorted angle in AF patients.



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