Efficacy and safety of bivalirudin in patients receiving clopidogrel therapy after diagnostic angiography for percutaneous coronary intervention in acute coronary syndromes

2010 ◽  
Vol 76 (4) ◽  
pp. 513-524 ◽  
Author(s):  
Dmitriy N. Feldman ◽  
Robert M. Minutello ◽  
Geoffrey Bergman ◽  
Issam Moussa ◽  
S. Chiu Wong
Keyword(s):  
Percutaneous Coronary Intervention ◽  
Acute Coronary Syndromes ◽  
Coronary Intervention ◽  
Efficacy And Safety ◽  
Percutaneous Coronary ◽  
Diagnostic Angiography ◽  
Clopidogrel Therapy ◽  
Coronary Syndromes

scholarly journals Prasugrel versus ticagrelor in patients with Acute Coronary syndrome treated with percutaneous coronary intervention

2018 ◽  
Vol 6 (6) ◽  
pp. 1945
Author(s):  
Naveen Jamwal ◽  
Shiv Shanker Tripathi
Keyword(s):  
Percutaneous Coronary Intervention ◽  
Acute Coronary Syndrome ◽  
Acute Coronary Syndromes ◽  
Association Studies ◽  
Coronary Intervention ◽  
Efficacy And Safety ◽  
Target Vessel Revascularization ◽  
Coronary Syndrome ◽  
Percutaneous Coronary ◽  
Coronary Syndromes

Background: No association studies for the efficacy and safety of ticagrelor vs. prasugrel have been published in India. Aim of the study was to compare the safety and efficacy of Prasugrel versus Ticagrelor in Patients with Acute Coronary Syndrome Treated with Percutaneous Coronary Intervention.Methods: This retrospective study was designed to compare the efficacy and safety of prasugrel and ticagrelor in acute coronary syndromes (ACS) with percutaneous coronary intervention (PCI). A total of 480 patients were studied who had been prescribed either prasugrel or ticagrelor during PCI. Primary end-point was defined as death, re-infarction, urgent target vessel revascularization, serious bleeding requiring transfusion.Results: Primary endpoint was different between the groups receiving prasugrel and ticagrelor (1.2% and 4.0%, respectively; OR (95% CI) 0.38 (0.098; 1.43); P=0.065). Difference was found in the need for urgenttarget vessel revascularization which was significantly lower in the prasugrel group.Rest of the parameters were almost similar with no significant difference.Conclusions: This study comparing prasugrel and ticagrelor shows that Prasugrel is more effective than Ticagrelor in lowering ischemic events in the acute coronary syndromes treated with PCI strategy, especially incidence of stent thrombosis. These observations need further analysis and follow-up.

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