scholarly journals Intravenous xenogeneic transplantation of human adipose-derived stem cells improves left ventricular function and microvascular integrity in swine myocardial infarction model

2015 ◽  
Vol 86 (2) ◽  
pp. E38-E48 ◽  
Author(s):  
Soon Jun Hong ◽  
Pamela I. Rogers ◽  
John Kihlken ◽  
Jessica Warfel ◽  
Chris Bull ◽  
...  
Keyword(s):  
Myocardial Infarction ◽  
Stem Cells ◽  
Left Ventricular Function ◽  
Ventricular Function ◽  
Left Ventricular ◽  
Adipose Derived Stem Cells ◽  
Xenogeneic Transplantation

scholarly journals Stem Cells Improve Left Ventricular Function in Acute Myocardial Infarction

2009 ◽  
Vol 32 (4) ◽  
pp. 176-180 ◽  
Author(s):  
Sarabjeet Singh ◽  
Rohit Arora ◽  
Kamna Handa ◽  
Ahmad Khraisat ◽  
Nagapradeep Nagajothi ◽  
...  
Keyword(s):  
Myocardial Infarction ◽  
Acute Myocardial Infarction ◽  
Stem Cells ◽  
Left Ventricular Function ◽  
Ventricular Function ◽  
Left Ventricular

scholarly journals Mobilization of bone marrow-derived stem cells after myocardial infarction and left ventricular function

2005 ◽  
Vol 26 (12) ◽  
pp. 1196-1204 ◽  
Author(s):  
Antonio Maria Leone ◽  
Sergio Rutella ◽  
Giuseppina Bonanno ◽  
Antonio Abbate ◽  
Antonio G. Rebuzzi ◽  
...  
Keyword(s):  
Myocardial Infarction ◽  
Stem Cells ◽  
Bone Marrow ◽  
Left Ventricular Function ◽  
Ventricular Function ◽  
Left Ventricular

Bone Marrow Stem Cells Infusion in Treatment of Patients with Acute Myocardial Infarction.

Blood ◽  
2006 ◽  
Vol 108 (11) ◽  
pp. 1682-1682
Author(s):  
Lidia Gil ◽  
Anna Czyz ◽  
Krzysztof Sawinski ◽  
Maria Kozlowska-Skrzypczak ◽  
Mieczyslaw Komarnicki ◽  
...  
Keyword(s):  
Myocardial Infarction ◽  
Acute Myocardial Infarction ◽  
Stem Cells ◽  
Bone Marrow ◽  
Left Ventricular Function ◽  
Ventricular Function ◽  
Left Ventricular ◽  
Control Group ◽  
Acute Pulmonary Oedema ◽  
Autologous Plasma

Abstract Experimental and clinical data show that bone marrow-derived stem cells (BMSC) can contribute to myocardial regeneration after ischemic injury. We present results of intracoronary infusion of autologous BMSCs in treatment of patients (pts) with acute myocardial infarction (MI). 36 pts with first, anterior wall MI, successfully treated with percutaneous coronary angioplasty were enrolled into the study. 24 pts, aged 50.1±9.05 yrs received intracoronary BMSC infusion 4 to 7 days after MI. Control group consisted of 12 pts, aged 51.6±8.7 yrs. In BMSC group BM in total volume 80 (50–150) ml was collected from iliac crest to buffered saline with heparine. After isolation and 18–24 hrs cultivation BMSCs were resuspended in autologous plasma in final volume 12.25±2.05 ml. The mean number of MNC, CD34+, CD133+/CD45+ and CD133+/CD45− cells were respectively: 0.41±0.18x10e9, 3.89±1.45x10e6, 0.96±0.6x10e6, 0.15±0.1x10e6. Transplanted material was divided into 3–5 portion and injected directly to infarcted area (Strauer method). Left ventricular function was evaluated by echocardiography (contactility index, CI), Tc-99 MIBI SPECT (perfusion index, PI) at rest (R) and with dipiridamol (D) and radionuclide ventriculography (ejection fraction, EF) at baseline and after 3, 6, 12 months (mo). CI and PI were assessed in left ventricle and infarct related artery (IRA) area. Control coronary angiography was performed after 6 mo. No adverse effects of BM aspiration in early MI were observed. One pts revealed chills and fever and 1 acute pulmonary oedema after cell infusion. Control angiography revealed restenosis in 3 pts from BMSC and 2 from control group. Results of cardiac test are presented in table. Conclusions: Intracoronary autologous BMNCs transplantation is safe and feasible. Improvement of left ventricular function was observed in BMSC group, mainly concerning perfusion. No accelerated atherosclerosis was seen after intracoronary BMSC administration. Results of cardiac tests BMSC group Control group p CI/CI-IRA 7 day 1.62±0.19/2.3±0.36 1.6±0.24/2.21±0.41 ns CI/CI-IRA 3 mo 1.55±0.2/2.12±0.4 1.65±0.3/2.34±0.64 ns CI/CI-IRA 6 mo 1.5±0.2/2.16±0.37 1.7±0.29/2.46±0.51 0.02 CI/CI-IRA 12 mo 1.55±0.2/2.24±0.44 1.72±0.33/2.48±0.51 ns Pi/PI-IRA-R 10 day 2.45±0.63/2.96±0.88 2.45±0.53/3.04±0.74 ns PI/PI-IRA-R 3 mo 2.25±0.37/2.79±0.61 2.36±0.44/2.88±0.61 ns PI/PI-IRA-R 6 mo 2.19±0.43/2.68±0.67 2.43±0.32/3.02±0.45 0.07 PI/PI-IRA-R 12 mo 2.11±0.33/2.63±0.46 2.36±0.31/2.98±0.46 ns PI/PI-IRA-D 10 day 2.45±0.63/2.96±0.88 2.45±0.53/3.04±0.74 ns PI/PI-IRA-D 3 mo 2.3±0.42/2.87±0.67 2.43±0.4/2.93±0.44 ns PI/PI-IRA-D 6 mo 2.2±0.44/2.58±0.83 2.48±0.43/3.12±0.48 0.06 PI/PI-IRA-D 12 mo 2.16±0.43/2.59±0.6 2.57±0.44/3.35±0.42 0.009 EF 4 day 45.0±7.9 41.6±6.6 ns EF 6 mo 48.2±9.2 42.1±11.4 0.07 EF 12 mo 48.5±4.9 38.9±7.7 0.002

scholarly journals Intramyocardial Injections of Human Mesenchymal Stem Cells following Acute Myocardial Infarction Modulate Scar Formation and Improve Left Ventricular Function

2012 ◽  
Vol 21 (8) ◽  
pp. 1697-1709 ◽  
Author(s):  
Jan Otto Beitnes ◽  
Erik Øie ◽  
Aboulghassem Shahdadfar ◽  
Tommy Karlsen ◽  
Regine M. B. Müller ◽  
...  
Keyword(s):  
Myocardial Infarction ◽  
Acute Myocardial Infarction ◽  
Stem Cells ◽  
Mesenchymal Stem Cells ◽  
Left Ventricular Function ◽  
Ventricular Function ◽  
Human Mesenchymal Stem Cells ◽  
Left Ventricular ◽  
Scar Formation

Human Dental Pulp Stem Cells Improve Left Ventricular Function, Induce Angiogenesis, and Reduce Infarct Size in Rats with Acute Myocardial Infarction

Stem Cells ◽  
2008 ◽  
Vol 26 (3) ◽  
pp. 638-645 ◽  
Author(s):  
Carolina Gandia ◽  
Ana Armiñan ◽  
Jose Manuel García-Verdugo ◽  
Elisa Lledó ◽  
Amparo Ruiz ◽  
...  
Keyword(s):  
Myocardial Infarction ◽  
Acute Myocardial Infarction ◽  
Stem Cells ◽  
Left Ventricular Function ◽  
Infarct Size ◽  
Ventricular Function ◽  
Dental Pulp ◽  
Left Ventricular ◽  
Reduce Infarct Size ◽  
Human Dental Pulp

Effects of autologous bone marrow derived CD34+ stem cells on the left ventricular function following myocardial infarction

2007 ◽  
Vol 148 (6) ◽  
pp. 243-249 ◽  
Author(s):  
László Balogh ◽  
István Czuriga ◽  
János Hunyadi ◽  
László Galuska ◽  
Éva Kristóf ◽  
...  
Keyword(s):  
Myocardial Infarction ◽  
Stem Cells ◽  
Bone Marrow ◽  
Left Ventricular Function ◽  
Ventricular Function ◽  
Fdg Pet ◽  
Autologous Bone Marrow ◽  
Left Ventricular ◽  
Autologous Bone ◽  
Mibi Spect

A kísérletes és az utóbbi 5 évben végzett humán klinikai vizsgálatok szerint a csontvelői eredetű sejtek részt vesznek a miokardiális infarktus gyógyulási folyamatában. Számos kisebb klinikai vizsgálatban mutattak ki enyhe vagy mérsékelt fokú kedvező hatást a miokardiális infarktus után intracoronariásan beadott csontvelői eredetű őssejtekkel. Mivel a legtöbb eddigi vizsgálatban mononukleáris frakciót használtak, a sejtpopuláció sokfélesége miatt nem volt ismert, hogy melyik a hatásos szubpopuláció. 8 miokardiális infarktust szenvedett, csökkent bal kamra funkciójú betegben vizsgáltuk az akut coronaria esemény után 12 ± 1 nappal intracoronariásan végzett CD34+ saját csontvelői őssejt beültetés biztonságosságát és hatékonyságát. 2D-echocardiographia, FDG-PET és MIBI-SPECT vizsgálatot végeztünk a beültetés előtt és 6 hónappal azt követően. A 6 hónapos követés során szignifikánsan javult a globális bal kamra funkció (alap EF 37,3 ± 2,9%, sejt kezelés után 44,8 ± 4,1%; p = 0,0041) és a regionális viabilitás / metabolizmus (17,6 ± 13,5%-kal; p < 0,05). A szívizom elhalt részének perfúziójában nem szignifikáns tendenciózus növekedést észleltünk. Eredményeinkkel elsőként mutattuk ki, hogy a CD34+ csontvelői sejt szubpopuláció javítja a bal kamra funkciót és a metabolizmust miokardiális infarktust követően.

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