Utilization of Focused Beam Reflectance Measurement in the Control of Crystal Size Distribution in a Batch Cooled Crystallizer

2006 ◽  
Vol 29 (2) ◽  
pp. 206-211 ◽  
Author(s):  
S. Barthe ◽  
R. W. Rousseau
Keyword(s):  
Size Distribution ◽  
Crystal Size ◽  
Crystal Size Distribution ◽  
Reflectance Measurement ◽  
Focused Beam

Evaluation of focused beam reflectance measurement (FBRM) for monitoring and predicting the crystal size of carbamazepine in crystallization processes

CrystEngComm ◽  
2021 ◽  
Author(s):  
David Acevedo ◽  
Wei-Lee Wu ◽  
Xiaochuan Yang ◽  
Naresh Pavurala ◽  
Adil Mohammad ◽  
...  
Keyword(s):  
Size Distribution ◽  
Model Compound ◽  
Crystal Size ◽  
Crystal Size Distribution ◽  
Reflectance Measurement ◽  
Focused Beam

Pharmaceutical crystallization affects the properties of APIs as it determines the purity and crystal size distribution, among other attributes. This work presents two CLD–CSD models, theoretical and empirical, for a model compound.

scholarly journals Tunable Protein Crystal Size Distribution via Continuous Slug-Flow Crystallization with Spatially Varying Temperature

CrystEngComm ◽  
2021 ◽  
Author(s):  
Nicholas Mozdzierz ◽  
Moo Sun Hong ◽  
Yongkyu Lee ◽  
Moritz Benisch ◽  
Mo Jiang ◽  
...  
Keyword(s):  
Product Quality ◽  
Size Distribution ◽  
Slug Flow ◽  
Crystal Size ◽  
Quality Attributes ◽  
Crystal Size Distribution ◽  
Protein Crystal ◽  
Manufacturing Cost ◽  
Spatially Varying

Accompanied with the growth of the biopharmaceuticals market has been an interest in developing processes with increased control of product quality attributes at low manufacturing cost, with one of the...

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