scholarly journals Amine Catalysis with Substrates Bearing N ‐Heterocyclic Moieties Enabled by Control over the Enamine Pyramidalization Direction

2020 ◽  
Vol 26 (67) ◽  
pp. 15623-15628 ◽  
Author(s):  
Jasper S. Möhler ◽  
Tobias Schnitzer ◽  
Helma Wennemers
Keyword(s):  
Amine Catalysis

Expanding the Scope of Primary Amine Catalysis: Stereoselective Synthesis of Indanedione-Fused 2,6-Disubstituted trans-Spirocyclohexanones

2016 ◽  
Vol 81 (6) ◽  
pp. 2420-2431 ◽  
Author(s):  
G. Madhusudhan Reddy ◽  
Chi-Ting Ko ◽  
Kai-Hong Hsieh ◽  
Chia-Jui Lee ◽  
Utpal Das ◽  
...  
Keyword(s):  
Primary Amine ◽  
Stereoselective Synthesis ◽  
Amine Catalysis

ChemInform Abstract: Stereodivergent α-Allylation of Linear Aldehydes with Dual Iridium and Amine Catalysis.

ChemInform ◽  
2014 ◽  
Vol 45 (37) ◽  
pp. no-no
Author(s):  
Simon Krautwald ◽  
Michael A. Schafroth ◽  
David Sarlah ◽  
Erick M. Carreira
Keyword(s):  
Amine Catalysis

Break the template boundary: Test of different protein scaffolds by genetic code expansion resulted in NADPH-dependent secondary amine catalysis

2021 ◽  
Author(s):  
Thomas Williams ◽  
Yu-Hsuan Tsai ◽  
Louis Luk
Keyword(s):  
Genetic Code ◽  
Secondary Amine ◽  
Transfer Hydrogenation ◽  
Protein Scaffolds ◽  
Artificial Enzyme ◽  
Enzyme Design ◽  
Catalytically Active ◽  
Amine Catalysis ◽  
Genetic Code Expansion ◽  
Distinctive Role

Abstract Here, incorporation of secondary amine by genetic code expansion was used to expand the potential protein templates for artificial enzyme design. Pyrrolysine analogue containing a D-proline could be stably incorporated into proteins, including the multidrug-binding LmrR and nucleotide-binding dihydrofolate reductase (DHFR). Both modified scaffolds were catalytically active, mediating transfer hydrogenation with a relaxed substrate scope. The protein templates played a distinctive role in that, while the LmrR variants were confined to the biomimetic BNAH as the hydride source, the optimal DHFR variant favorably used the pro-R hydride from NADPH for reactions. Due to the cofactor compatibility, the DHFR secondary amine catalysis could also be coupled to an enzymatic recycling scheme. This work has illustrated the unique advantages of using proteins as hosts, and thus the presented concept is expected to find uses in enabling tailored secondary amine catalysis.

Chiral Primary Amine Catalysis for Asymmetric Mannich Reactions of Aldehydes with Ketimines: Stereoselectivity and Reactivity

2017 ◽  
Vol 56 (41) ◽  
pp. 12697-12701 ◽  
Author(s):  
Jun Dai ◽  
Dan Xiong ◽  
Tengrui Yuan ◽  
Juan Liu ◽  
Tao Chen ◽  
...  
Keyword(s):  
Primary Amine ◽  
Mannich Reactions ◽  
Amine Catalysis

Asymmetric Retro-Claisen Reaction by Chiral Primary Amine Catalysis

2016 ◽  
Vol 138 (12) ◽  
pp. 3978-3981 ◽  
Author(s):  
Yunbo Zhu ◽  
Long Zhang ◽  
Sanzhong Luo
Keyword(s):  
Primary Amine ◽  
Amine Catalysis ◽  
Claisen Reaction

scholarly journals Synergetic iridium and amine catalysis enables asymmetric [4+2] cycloadditions of vinyl aminoalcohols with carbonyls

2019 ◽  
Vol 10 (1) ◽  
Author(s):  
Mao-Mao Zhang ◽  
Ya-Ni Wang ◽  
Bao-Cheng Wang ◽  
Xiao-Wang Chen ◽  
Liang-Qiu Lu ◽  
...  
Keyword(s):  
Amine Catalysis

scholarly journals Synergistic catalysis: enantioselective cyclopropanation of alkylidene benzoxazoles by Pd(ii) and secondary amine catalysis. Scope, limitations and mechanistic insight

2018 ◽  
Vol 5 (5) ◽  
pp. 806-812 ◽  
Author(s):  
Marta Meazza ◽  
Victor Polo ◽  
Pedro Merino ◽  
Ramon Rios
Keyword(s):  
Dft Calculations ◽  
Secondary Amine ◽  
Ring Opening ◽  
Synergistic Catalysis ◽  
Mechanistic Insight ◽  
Amine Catalysis

An enantioselective synergistic cascade cyclopropanation/NHC catalyzed ring opening has been reported. DFT calculations have been performed to confirm the mechanism.

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