ChemInform Abstract: CARBON-13 NMR SPECTRA OF 1-ARYLPROPYNES AND 1-ARYLPROPENES, TRANSMISSION OF THE ELECTRONIC EFFECTS OF SUBSTITUENTS THROUGH CARBON-CARBON TRIPLE AND DOUBLE BONDS

1973 ◽  
Vol 4 (50) ◽  
pp. no-no
Author(s):  
KUNISUKE IZAWA ◽  
TADASHI OKUYAMA ◽  
TAKAYUKI FUENO
Keyword(s):  
Nmr Spectra ◽  
Double Bonds ◽  
Electronic Effects ◽  
Electronic Effects Of Substituents

13C NMR spectra of N-substituted carbazoles. Transmission of the electronic effects of substituents through the nitrogen atom to the carbazole ring

1986 ◽  
Vol 22 (9) ◽  
pp. 956-959
Author(s):  
V. D. Filimonov ◽  
T. A. Filippova ◽  
V. P. Lopatinskii ◽  
M. M. Sukhoroslova ◽  
N. V. Stepanov
Keyword(s):  
Nitrogen Atom ◽  
13C Nmr ◽  
Nmr Spectra ◽  
13C Nmr Spectra ◽  
Electronic Effects ◽  
Electronic Effects Of Substituents

Transmission of substituent effects in N-(p-substituted phenyl)-phthalimides

1990 ◽  
Vol 55 (1) ◽  
pp. 261-272 ◽  
Author(s):  
Miroslav Holík ◽  
Božena Matějková
Keyword(s):  
Conformational Changes ◽  
Nmr Spectra ◽  
Electronic Effect ◽  
Chemical Shifts ◽  
Substituent Effects ◽  
Principal Component ◽  
Electronic Effects ◽  
Diamagnetic Anisotropy ◽  
Electronic Effects Of Substituents ◽  
C Nmr

Chemical shifts of benzene part of the title compounds have been correlated with substituent chemical shifts (SCS) increments a for 1H and z for 13C NMR spectra. These correlations gave pieces of information not only about the through-conjugation of substituents but also about the change of the twist about the central N-C bond with the change of substituent in the para-position. In such a way the electronic effects of substituents have been studied together with the effects due to conformational changes which manifest themselves with the change in the van der Waals repulsion and/or diamagnetic anisotropy of double bond. Chemical shifts in phthalimide part of molecule have been related to the electronic effect of distant substituent after separation of the main source of variation from random error by principal component analysis.

scholarly journals An Electrochemical Evaluation of Novel Ferrocene Derivatives for Glutamate and Liver Biomarker Biosensing

Biosensors ◽  
2021 ◽  
Vol 11 (8) ◽  
pp. 254
Author(s):  
Geok Hong Soon ◽  
Mary Deasy ◽  
Eithne Dempsey
Keyword(s):  
Film Studies ◽  
Redox Potentials ◽  
Signal Loss ◽  
Electronic Effects ◽  
Ferrocene Derivatives ◽  
Electroactive Films ◽  
Glutamate Oxidase ◽  
Electronic Effects Of Substituents ◽  
Glutamyl Transpeptidase

Here, we present an evaluation of two new monosubstituted ferrocene (Fc) derivatives, 3-(1H-pyrrol-1-yl)propanamidoferrocene and 1-hydroxy-2-[2-(thiophen-3-yl)-ethylamino]ethylferrocene, as glutamate oxidase mediators, together with their preparation and characterisation. Taking into consideration the influence of the electronic effects of substituents on the redox potentials of the Fc species, two candidates with pyrrole or thiophene moieties were proposed for investigation. Film studies involved potential sweeping in the presence of pyrrole or 3,4-ethylenedioxythiophene monomers resulting in stable electroactive films with % signal loss upon cycling ranging from 1 to 7.82% and surface coverage (Γ) 0.47–1.15 × 10−9 mol/cm2 for films formed under optimal conditions. Construction of a glutamate oxidase modified electrode resulted in second-generation biosensing with the aid of both cyclic voltammetry and hydrodynamic amperometry, resulting in glutamate sensitivity of 0.86–1.28 μA/mM and Km (app) values over the range 3.67–5.01 mM. A follow-up enzyme assay for liver biomarker γ-glutamyl transpeptidase realised unmediated and mediated measurement establishing reaction and incubation time investigations and a realising response over <100 U/L γ-glutamyl transpeptidase with a sensitivity of 5 nA/UL−1.

Correlation of structural parameters with antituberculotic activity in a group of 2-benzamidobenzothiazoles

1991 ◽  
Vol 56 (12) ◽  
pp. 2978-2985 ◽  
Author(s):  
Karel Waisser ◽  
Jiří Kuneš ◽  
Želmíra Odlerová
Keyword(s):  
Structural Parameters ◽  
Regression Equations ◽  
Electronic Effects ◽  
Active Compounds ◽  
Qsar Analysis ◽  
Active Structures ◽  
Benzoyl Group ◽  
Electronic Effects Of Substituents

Fourteen 2-benzamidobenzothiazole derivatives substituted in the benzoyl group and 2-cinnamamidobenzothiazole have been synthesized. The prediction of active structures by the method by Topliss gives incorrect results but, as shown on the basis of the Hansch QSAR analysis, the 2-(4-dimethylaminobenzamido)benzothiazole synthesized on the basis of the QSAR procedure by Topliss behaves anomalously also in the procedure by Hansch. Regression equations of the Hansch type have been found in which the antituberculotic activity is interpreted by lipophilicity and electronic effects of substituents. When tested in vitro, the most active compounds are comparable with ethionamide.

Transmission of the electronic effects of substituents by the thiophene ring

1974 ◽  
Vol 10 (7) ◽  
pp. 801-805 ◽  
Author(s):  
L. P. Pivovarevich ◽  
L. A. Kutulya ◽  
Yu. N. Surov ◽  
S. V. Tsukerman ◽  
V. F. Lavrushin
Keyword(s):  
Thiophene Ring ◽  
Electronic Effects ◽  
Electronic Effects Of Substituents
Sign in / Sign up

Export Citation Format

Share Document