ChemInform Abstract: Photosensitized NAD(P)H Regeneration Systems; Application in the Reduction of Butan-2-one, Pyruvic, and Acetoacetic Acids and in the Reductive Amination of Pyruvic and Oxoglutaric Acid to Amino Acid.

1986 ◽  
Vol 17 (39) ◽  
Author(s):  
D. MANDLER ◽  
I. WILLNER
Molecules ◽  
2020 ◽  
Vol 25 (6) ◽  
pp. 1313
Author(s):  
Andrea Temperini ◽  
Donatella Aiello ◽  
Fabio Mazzotti ◽  
Constantinos M. Athanassopoulos ◽  
Pierantonio De Luca ◽  
...  

A synthetic strategy for the preparation of two orthogonally protected methyl esters of the non-proteinogenic amino acid 2,3-l-diaminopropanoic acid (l-Dap) was developed. In these structures, the base-labile protecting group 9-fluorenylmethyloxycarbonyl (Fmoc) was paired to the p-toluensulfonyl (tosyl, Ts) or acid-labile tert-butyloxycarbonyl (Boc) moieties. The synthetic approach to protected l-Dap methyl esters uses appropriately masked 2,3-diaminopropanols, which are obtained via reductive amination of an aldehyde prepared from the commercial amino acid Nα-Fmoc-O-tert-butyl-d-serine, used as the starting material. Reductive amination is carried out with primary amines and sulfonamides, and the process is assisted by the Lewis acid Ti(OiPr)4. The required carboxyl group is installed by oxidizing the alcoholic function of 2,3-diaminopropanols bearing the tosyl or benzyl protecting group on the 3-NH2 site. The procedure can easily be applied using the crude product obtained after each step, minimizing the need for chromatographic purifications. Chirality of the carbon atom of the starting d-serine template is preserved throughout all synthetic steps.


2020 ◽  
Vol 8 (46) ◽  
pp. 17054-17061
Author(s):  
Rui-Feng Cai ◽  
Lei Liu ◽  
Fei-Fei Chen ◽  
Aitao Li ◽  
Jian-He Xu ◽  
...  

Tetrahedron ◽  
1992 ◽  
Vol 48 (9) ◽  
pp. 1715-1728 ◽  
Author(s):  
David B. Berkowitz ◽  
W. Bernd Schweizer

PLoS ONE ◽  
2013 ◽  
Vol 8 (1) ◽  
pp. e53231 ◽  
Author(s):  
Paula Pérez-Faginas ◽  
M. Teresa Aranda ◽  
M. Teresa García-López ◽  
Lourdes Infantes ◽  
Asia Fernández-Carvajal ◽  
...  

2020 ◽  
Vol 10 (10) ◽  
pp. 3376-3386 ◽  
Author(s):  
Xinjian Yin ◽  
Yayun Liu ◽  
Lijun Meng ◽  
Haisheng Zhou ◽  
Jianping Wu ◽  
...  

The hinge region was identified to be a promising hotspot for activity engineering of GluDHs, providing a potent alternative for developing high-performance biocatalysts toward valuable optically pure l-amino acid production.


Sign in / Sign up

Export Citation Format

Share Document