ChemInform Abstract: The Two-Solid-State Conformations of Nefopam Methiodide, a Quaternary Ammonium Salt of the Analgesic Drug

The solid-state structure of nefopam methiodide, a quaternary ammonium salt of nefopam hydrochloride (a non-narcotic analgesic drug), has been determined by single crystal X-ray diffraction analysis. Nefopam methiodide gives crystals belonging to the monoclinic P21/c space group and, at 298 K, a = 10.001(1), b = 9.928(1), c = 17.598(1) Å, β = 94.41(1)°, V = 1742.2(2) Å3, Z = 4, R(F) = 0.086, and Rw(F) = 0.108. Due to disorder, the boat (flattened chair) and twist-chair (flattened chair) conformations of the 2,5-benzoxazocine eight-membered ring were both observed in the crystal with 55:45 occupancy, respectively. Positional disorder was also observed for the iodide counterion, which showed occupancies of 81:9.5:9.5. Keywords: nefopam, analgesic, X-ray crystallography, conformation.

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Catalyst- and oxidant-free electrochemical para-selective hydroxylation of N-arylamides in batch and continuous-flow

Green Chemistry ◽

10.1039/d0gc02294b ◽

2020 ◽

Vol 22 (19) ◽

pp. 6437-6443

Author(s):

Cheng-Kou Liu ◽

Meng-Yi Chen ◽

Xin-Xin Lin ◽

Zheng Fang ◽

Kai Guo

Keyword(s):

Ammonium Salt ◽

Quaternary Ammonium ◽

Continuous Flow ◽

Quaternary Ammonium Salt ◽

Selective Hydroxylation

A catalyst-, oxidant-, acidic solvent- and quaternary ammonium salt-free electrochemical para-selective hydroxylation of N-arylamides at rt in batch and continuous-flow was developed.

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Synthesis and Performance of Polyoxy-ethylene Ester Quaternary Ammonium Salt

Tenside Surfactants Detergents ◽

10.3139/113.110224 ◽

2013 ◽

Vol 50 (1) ◽

pp. 9-13 ◽

Cited By ~ 4

Author(s):

Yong-Qiang Sun ◽

Wen-Jing Li ◽

Wan-Xu Wang ◽

Qiu-Xiao Li ◽

Wieslaw Hreczuch ◽

...

Keyword(s):

Ammonium Salt ◽

Quaternary Ammonium ◽

Quaternary Ammonium Salt ◽

And Performance

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Instability of Solutions of Quaternary Ammonium Permanganates in Dichloromethane

Collection of Czechoslovak Chemical Communications ◽

10.1135/cccc19970849 ◽

1997 ◽

Vol 62 (6) ◽

pp. 849-854 ◽

Cited By ~ 4

Author(s):

Vladislav Holba ◽

Renata Košická

Keyword(s):

Ammonium Salt ◽

Rate Constants ◽

Quaternary Ammonium ◽

Quaternary Ammonium Salt ◽

Activation Parameters ◽

The Stability

The paper deals with instability of solutions of quaternary ammonium permanganates, QMnO4 (Q = tetraethyl-, tetra-1-propyl-, tetra-1-butyl-, tetra-1-pentyl-, tetra-1-octyl-, and cetyltrimethylammonium), in dichloromethane and presents the rate constants and activation parameters of the reduction of permanganate. Attention was paid to the properties of colloidal Mn(IV) intermediate. The stability of the solutions depends markedly on the quaternary ammonium salt used.

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Systematic exploration of quaternary ammonium salt adsorption on oxidized coal based on experiments and MD simulations

Fuel ◽

10.1016/j.fuel.2020.119434 ◽

2021 ◽

Vol 287 ◽

pp. 119434

Author(s):

Jun Chen ◽

Hongliang Li ◽

Chunfu Liu ◽

Lingyun Liu ◽

Yu Sun ◽

...

Keyword(s):

Ammonium Salt ◽

Quaternary Ammonium ◽

Quaternary Ammonium Salt ◽

Md Simulations ◽

Oxidized Coal ◽

Systematic Exploration

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Antibacterial performance of polymer quaternary ammonium salt–capped silver nanoparticles on Bacillus subtilis in water

RSC Advances ◽

10.1039/c9ra05944j ◽

2019 ◽

Vol 9 (44) ◽

pp. 25667-25676 ◽

Cited By ~ 1

Author(s):

Jingyu Wang ◽

Minghao Sui ◽

Zhanfang Ma ◽

Hongwei Li ◽

Bojie Yuan

Keyword(s):

Silver Nanoparticles ◽

Bacillus Subtilis ◽

Ammonium Salt ◽

Quaternary Ammonium ◽

Quaternary Ammonium Salt ◽

Antibacterial Performance ◽

Antibacterial Capacity

Polymer quaternary ammonium salt–capped silver nanoparticles (PQAS–AgNPs) were synthesized, and they exhibited significant antibacterial capacity against Bacillus subtilis.

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