ChemInform Abstract: Oxidative Degradation of L-Ascorbic Acid Acetals to 2′,3′-Dideoxy-3′- oxaribofuranosides. Synthesis of Enantiomerically Pure 2′,3′-Dideoxy-3′ -oxacytidine Stereoisomers as Potential Antiviral Agents.

ChemInform ◽  
2010 ◽  
Vol 24 (15) ◽  
pp. no-no
Author(s):  
B. R. BELLEAU ◽  
C. A. EVANS ◽  
H. L. A. TSE ◽  
H. JIN ◽  
D. M. DIXIT ◽  
...  
Keyword(s):  
Ascorbic Acid ◽  
Antiviral Agents ◽  
Oxidative Degradation ◽  
Enantiomerically Pure

ChemInform Abstract: 6-Deoxy-6-fluoro-L-ascorbic Acid: Crystal Structure and Oxidative Degradation.

ChemInform ◽  
2001 ◽  
Vol 32 (4) ◽  
pp. no-no
Author(s):  
Janusz Madaj ◽  
Yoko Nishikawa ◽  
V. Prakash Reddy ◽  
Peter Rinaldi ◽  
Tadao Kurata ◽  
...  
Keyword(s):  
Crystal Structure ◽  
Ascorbic Acid ◽  
Oxidative Degradation ◽  
Acid Crystal

scholarly journals Oxidative degradation of haemoglobin by nitrosobenzene in the erythrocyte

1978 ◽  
Vol 174 (3) ◽  
pp. 693-697 ◽  
Author(s):  
K Hirota ◽  
H A Itano ◽  
T S Vedvick
Keyword(s):  
Ascorbic Acid ◽  
Benzene Ring ◽  
Oxidative Degradation ◽  
Oxidative Cleavage ◽  
Oxidative Conversion ◽  
Active Intermediate

Substitutions on the benzene ring of nitrosobenzene did not have the same effect on oxidative haemolysis as substitutions on phenylhydrazine. We previously found that the haemolytic effect of arylhydrazines paralleled their oxidative conversion into ligands of ferrihaemoglobin. In contrast, although most substituted nitrosobenzenes that are ligands of ferrohaemoglobin caused haemolysis and most that are not ligands failed to cause nitrosoarenes appeared to be related more closely to the ease of their reduction to arylhydroxylamines than to their properties as ligands. We propose a mechanism of oxidative degradation whereby the cyclic formation of phenylhydroxylamine from nitrosobenzene within an erythrocyte leads to the accumulation of H2O2, which then reacts with ferrohaemoglobin to initiate the oxidative cleavage of haem. The posulated active intermediate in this reaction is the same as that previously proposed in the oxidative degradation of haemoglobin by phenylhydrzine and in the coupled oxidation of ascorbic acid and haemoglobin.

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