ChemInform Abstract: New Antibacterial Agents: Synthesis and Antibacterial Activity of Heterocyclic Derivatives of Pseudomonic Acid

Coumarin is a heterocyclic moiety containing benzo pyran ring structure. It is widely distributed in the plant kingdom as a glycoside. Many compounds of medicinal and pharmaceutical importance possess coumarin ring structure. Drugs with coumarin structure can be synthesized by many well-known synthetic reactions. Coumarin derivatives were found to be antibacterial, anticoagulant, antiinflammatory, anti-HIV, anti-cancer and antioxidant. As part of the search for new and effective antibacterial agents, eight novel derivatives of coumarins were synthesized by Mannich reaction. All the compounds were evaluated for antibacterial activity against Staphylococcus aureus and Escherichia coli using ciprofloxacin as standard and DMSO as solvent. Three of the synthesized derivatives exhibited good antibacterial activity against Staphylococcus aureus and Escherichia coli. The work must be extended so as to develop coumarin derivatives into highly effective antibacterial agents.

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Microwave Synthesis and Characterization of Antibacterial Activity Evaluation of 2-(4, 5-dihydro-5-(4-chlorophenyl)-1H-pyrazol-3-yl) phenol

South Asian Journal of Engineering and Technology ◽

10.26524/sa1 ◽

2018 ◽

Vol 7 (3) ◽

pp. 01-07

Author(s):

L Ilavarasan ◽

A Ravi ◽

M Ganapathi ◽

E Subitchayini ◽

K Sivasakthi ◽

...

Keyword(s):

Antibacterial Activity ◽

Inhibitory Concentration ◽

Spectral Techniques ◽

Peg 400 ◽

Heterocyclic Derivatives ◽

Ft Ir ◽

Uv Visible ◽

Benzaldehyde Derivatives ◽

Derivatives Of

Chalcone derivatives were synthesized by reaction of some benzaldehyde derivatives with acetophenone, then the products obtained were allowed to react withurea, thiourea and hydroxylamine, to give the heterocyclic derivatives of oxazine, thiazine and isoxazole, respectively.In this study, a series of chalcones and substituted pyrazole compounds were synthesized according to green chemistry methods of conventional and microwave irradiation by using substituted acetophenone, substituted benzaldehyde, hydrazine hydrate and PEG-400. The synthesized compounds were characterized by UV-Visible, FT-IR and 1H NMR spectral techniques. The purity of the synthesized compounds were monitored by TLC and tested for their antibacterial activity by Minimum Inhibitory Concentration (MIC) method against two different microorganisms Staphylococcus auras (MTCC3381), and Escherichia coli (MTCC739).

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The Chemistry of Pseudomonic Acid. 17. Dual-Action C-1 Oxazole Derivatives of Pseudomonic Acid Having an Extended Spectrum of Antibacterial Activity†

Journal of Medicinal Chemistry ◽

10.1021/jm950882q ◽

1996 ◽

Vol 39 (18) ◽

pp. 3596-3600 ◽

Cited By ~ 15

Author(s):

Nigel J. P. Broom ◽

Robert Cassels ◽

Hung-Yuan Cheng ◽

John S. Elder ◽

Peter C. T. Hannan ◽

...

Keyword(s):

Antibacterial Activity ◽

Extended Spectrum ◽

Dual Action ◽

Pseudomonic Acid ◽

Derivatives Of ◽

Oxazole Derivatives

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ChemInform Abstract: The Chemistry of Pseudomonic Acid. Part 17. Dual-Action C-1 Oxazole Derivatives of Pseudomonic Acid Having an Extended Spectrum of Antibacterial Activity.

ChemInform ◽

10.1002/chin.199652274 ◽

2010 ◽

Vol 27 (52) ◽

pp. no-no

Author(s):

N. J. P. BROOM ◽

R. CASSELS ◽

H.-Y. CHENG ◽

J. S. ELDER ◽

P. C. T. HANNAN ◽

...

Keyword(s):

Antibacterial Activity ◽

Extended Spectrum ◽

Dual Action ◽

Pseudomonic Acid ◽

Derivatives Of ◽

Oxazole Derivatives

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Synthesis and biological evaluation of truncated derivatives of abyssomicin C as antibacterial agents

Beilstein Journal of Organic Chemistry ◽

10.3762/bjoc.15.147 ◽

2019 ◽

Vol 15 ◽

pp. 1468-1474

Author(s):

Leticia Monjas ◽

Peter Fodran ◽

Johanna Kollback ◽

Carlo Cassani ◽

Thomas Olsson ◽

...

Keyword(s):

Staphylococcus Aureus ◽

Antibacterial Activity ◽

Natural Product ◽

Antibacterial Agents ◽

Biological Evaluation ◽

Methicillin Resistant ◽

Structure Activity ◽

Synthesis And Biological Evaluation ◽

Derivatives Of ◽

Novel Antibiotics

The synthesis and antibacterial activity of two new highly truncated derivatives of the natural product abyssomicin C are reported. This work outlines the limits of structural truncation of the natural product and consequently provides insights for further structure–activity relationship studies towards novel antibiotics targeting 4-amino-4-deoxychorismate (ADC) synthase. Specifically, it is demonstrated that the synthetically challenging bicyclic motif is essential for activity towards methicillin-resistant Staphylococcus aureus (MRSA).

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