Microwave Synthesis and Characterization of Antibacterial Activity Evaluation of 2-(4, 5-dihydro-5-(4-chlorophenyl)-1H-pyrazol-3-yl) phenol

10.26524/sa1 ◽  
2018 ◽  
Vol 7 (3) ◽  
pp. 01-07
Author(s):  
L Ilavarasan ◽  
A Ravi ◽  
M Ganapathi ◽  
E Subitchayini ◽  
K Sivasakthi ◽  
...  
Keyword(s):  
Antibacterial Activity ◽  
Inhibitory Concentration ◽  
Spectral Techniques ◽  
Peg 400 ◽  
Heterocyclic Derivatives ◽  
Ft Ir ◽  
Uv Visible ◽  
Benzaldehyde Derivatives ◽  
Derivatives Of

Chalcone derivatives were synthesized by reaction of some benzaldehyde derivatives with acetophenone, then the products obtained were allowed to react withurea, thiourea and hydroxylamine, to give the heterocyclic derivatives of oxazine, thiazine and isoxazole, respectively.In this study, a series of chalcones and substituted pyrazole compounds were synthesized according to green chemistry methods of conventional and microwave irradiation by using substituted acetophenone, substituted benzaldehyde, hydrazine hydrate and PEG-400. The synthesized compounds were characterized by UV-Visible, FT-IR and 1H NMR spectral techniques. The purity of the synthesized compounds were monitored by TLC and tested for their antibacterial activity by Minimum Inhibitory Concentration (MIC) method against two different microorganisms Staphylococcus auras (MTCC3381), and Escherichia coli (MTCC739).

scholarly journals ISOLATION OF 2-CHLOROBENZIMIDAZOLE FROM MELIA DUBIA LEAF EXTRACT AND ITS STRUCTURAL CHARACTERISATION

2017 ◽  
Vol 9 (10) ◽  
pp. 67 ◽  
Author(s):  
G. Dayana Jeyaleela ◽  
S. Irudaya Monisha ◽  
J. Rosaline Vimala ◽  
A. Anitha Immaculate
Keyword(s):  
Mass Spectrometry ◽  
1H Nmr ◽  
Research Work ◽  
Proton Nuclear Magnetic Resonance ◽  
Resonance Spectroscopy ◽  
Ft Ir ◽  
Uv Visible ◽  
Isolated Compound ◽  
Promising Source

Objective: Natural products from medicinal plants, either as isolated compounds or as standardized plant extracts exhibit promising source of medicinal activity against various diseases. The aim of the present work was to make an attempt of isolation of bioactive principle and characterization of the isolated compound, from the medicinal plant Melia dubaiMethods: The extraction was done by a cold percolation method and the compound was separated and isolated by chromatography technique such as a thin layer chromatography (TLC), column chromatography and high-performance liquid chromatography (HPLC). The isolated compound was crystallized and the structural characterization of the isolated compound was made using UV-Visible, FT-IR, 1H-NMR, GC-MS and MS techniques which confirmed the structure of the isolated compound.Results: The separated and isolated compound was characterized by both physical and spectral methods like Ultraviolet-Visible spectroscopy (UV-Visible), Fourier transform infrared spectroscopy (FT-IR), Proton Nuclear Magnetic Resonance Spectroscopy (1H-NMR), Gas chromatography-mass spectrometry (GC-MS), and Mass spectrometry(MS). Based on the studies, organizational characteristics of one bioactive principle were deciphered. The results revealed that the isolated species is 2-chlorobenzimidazole and it agreed well with the reported value and spectra for 2-chlorobenzimidazole.Conclusion: The above results obtained in this research work clearly indicated the promising occurrence of 2-chlorobenzimidazole in Media dubia plant leaves. The future scope of these studies may guide us to view the biological activity of the isolated compound.

scholarly journals Antibacterial Properties of Biofilm Schiff Base Derived from Dialdehyde Cellulose and Chitosan

2019 ◽  
Vol 19 (2) ◽  
pp. 405
Author(s):  
Agung Pratama ◽  
Firman Sebayang ◽  
Rumondang Bulan Nasution
Keyword(s):  
Tensile Strength ◽  
Antibacterial Activity ◽  
Schiff Base ◽  
Antibacterial Properties ◽  
Oxidized Cellulose ◽  
Natural Polymers ◽  
Dialdehyde Cellulose ◽  
Ft Ir ◽  
Ir Analysis

Cellulose and chitosan are natural polymers that have been used as biocomposite. The aim of this research is to obtain biofilms from chitosan and oxidized cellulose crosslinks. This research is divided into three steps, i.e., isolation of cellulose from oil palm trunk and oxidation of cellulose using NaIO4 (0.2; 0.4; 0.6; 0.8; 1.0 mg/mL) to obtain dialdehyde cellulose (DAC), crosslink of oxidized cellulose with chitosan (DD = 72.85%) to obtain biofilm of chitosan/DAC (CDAC), and characterization of biofilms. The crosslinked reaction was confirmed by FT-IR analysis that showed the spectrum of Schiff base C=N group at 1651 cm–1. Tensile strength increased gradually when the NaIO4 concentration used was 0.2–0.6 mg/mL, but after those concentrations, the tensile strength slightly decreased. The morphology analysis showed that CDAC had smoother morphology than DAC, which was shown rough and showed some particle indicated the presence of unreacted cellulose. CDAC biofilms that prepared with 1.0 mg/mL NaIO4 showed the greatest antibacterial activity.

Characterization of antibacterial activity and mechanisms of two linear derivatives of bactenecin

LWT ◽  
2019 ◽  
Vol 107 ◽  
pp. 89-97 ◽  
Author(s):  
Fei Liu ◽  
Haimei Wang ◽  
Songsong Cao ◽  
Chenggang Jiang ◽  
Juncai Hou
Keyword(s):  
Antibacterial Activity ◽  
Derivatives Of

scholarly journals Synthesis, Characterization of Some Novel Benzimidazole Derivatives of 1-Bromo-2,4-dinitrobenzene and Their Antifungal Activities

2011 ◽  
Vol 8 (s1) ◽  
pp. S85-S90
Author(s):  
Abbas Ahmadi ◽  
Babak Nahri-Niknafs
Keyword(s):  
Biological Activity ◽  
Candida Albicans ◽  
Candida Glabrata ◽  
Inhibitory Concentration ◽  
Candida Krusei ◽  
Benzimidazole Derivatives ◽  
Spectroscopic Techniques ◽  
Antifungal Activities ◽  
Derivatives Of

Six novel benzimidazole derivatives, 5-nitro-2-phenyl -1-ethyl benzimidazol (5), 2- (p-bromophenyl)- 5-nitro- 1-ethyl benzimidazol (6), 2- (p-bromophenyl-5-nitro-1–cyclopentyl benzimidazol (7), 2- (p-bromophenyl) -5-nitro-1-cyclopentyl benzimidazol (8), 5-amino-2-(p-bromophenyl)-1-ethylbenzimidazol (9) and 5-amino-2-(p-bromophenyl)-1-cyclopentyl benzimidazol (10) were synthesized. The structures of all the synthesized compounds were elucidated by using elemental analysis and different spectroscopic techniques (IR, NMR and mass spectroscopy). Some of these compounds showed potential antifungal activities. The biological activity of these compounds as fungicides was tested against Candida albicans, patient isolate Candida glabrata and Candida krusei. The biological activity of four compounds was found to be comparable to that of the commercially available fungicides with a minimum inhibitory concentration of 12.5 µg/mL.

Synthesis and spectral properties of ruthenium(II) complexes with tetra-15-crown-5-phthalocyanine and N-donor ligands

2003 ◽  
Vol 07 (12) ◽  
pp. 795-800 ◽  
Author(s):  
Yuliya G. Gorbunova ◽  
Yuliya Yu. Enakieva ◽  
Sergey G. Sakharov ◽  
Aslan Yu. Tsivadze
Keyword(s):  
Spectral Properties ◽  
Donor Ligands ◽  
Preparation Technique ◽  
Reaction Products ◽  
H Nmr ◽  
Trimethylamine Oxide ◽  
Donor Solvent ◽  
Ft Ir ◽  
Uv Visible

The synthesis of novel bis-axially coordinated ruthenium(II) complexes with tetra-15-crown-5-phthalocyanine and N-donor ligands ( R 4 Pc ) Ru ( L 2) ( R 4Pc2- = 4,5,4',5',4'',5'', 4''',5'''- tetrakis(1,4,7,10,13-pentaoxotridecamethylene)phthalocyaninate-ion, L = pyridine (py), isoquino-line (iqnl), triethylamine ( Et 3 N )) is reported. The preparation technique involves the interaction of ( R 4 Pc ) Ru ( CO )( CH 3 OH ) with trimethylamine oxide in an N-donor solvent. The advantage of this method consists in selective carbonyl ejection from ( R 4 Pc ) Ru ( CO ) X with simultaneous substi-tution by N-donor ligands. The application of this procedure allowed us to decrease essentially the reaction time, as compared with photochemical methods, as well as to increase substantially the yield of reaction products. UV-visible, 1 H NMR, FT-IR and mass-spectrometry were used for characterization of the obtained compounds.

scholarly journals Inclusion Complexes of Concentrated Orange Oils and β-Cyclodextrin: Physicochemical and Biological Characterizations

Molecules ◽  
2020 ◽  
Vol 25 (21) ◽  
pp. 5109
Author(s):  
Cynthia Torres-Alvarez ◽  
Sandra Castillo ◽  
Eduardo Sánchez-García ◽  
Carlos Aguilera González ◽  
Sergio Arturo Galindo-Rodríguez ◽  
...  
Keyword(s):  
Antioxidant Activity ◽  
Antibacterial Activity ◽  
Minimum Inhibitory Concentration ◽  
Antifungal Activity ◽  
Inclusion Complexes ◽  
Inhibitory Concentration ◽  
Entrapment Efficiency ◽  
Ft Ir ◽  
Ir Analysis

Concentrated orange oils (5x, 10x, 20x) are ingredients used in different industries as components of flavors and aromas due to their great organoleptic qualities. This research focuses on the search for alternative uses for their application through encapsulation in inclusion complexes with β-cyclodextrin (β–CD). Inclusion complexes of concentrated orange oils (COEO) and β–CD were developed by the co-precipitated method in ratios of 4:96, 12:88, and 16:84 (w/w, COEO: β–CD). The best powder recovery was in the ratio 16:84 for the three oils, with values between 82% and 84.8%. The 20x oil in relation 12:88 showed the highest entrapment efficiency (89.5%) with 102.3 mg/g of β–CD. The FT-IR analysis may suggest an interaction between the oil and the β–CD. The best antioxidant activity was observed in the ratio 12:88 for the three oils. The antifungal activity was determined for all the inclusion complexes, and the 10x fraction showed the highest inhibition at a concentration of 10 mg/mL in ratios 12:88 and 16:84. Antibacterial activity was determined by the minimum inhibitory concentration (MIC) and was found at a concentration of 1.25 mg/mL in ratios 12:88 and 16:84 for 5x and 20x oils.

scholarly journals Efficient Synthesis and Characterization of Some Novel Nitro-Schiff Bases and Their Complexes of Nickel(II) and Copper(II)

2013 ◽  
Vol 2013 ◽  
pp. 1-8 ◽  
Author(s):  
Hossein Naeimi ◽  
Mohsen Moradian
Keyword(s):  
Schiff Base ◽  
Schiff Base Complexes ◽  
Synthesis And Characterization ◽  
Planar Geometry ◽  
Hydroxyl Groups ◽  
Spectroscopic Techniques ◽  
Spectral Techniques ◽  
Chemical Structures ◽  
Ft Ir

Synthesis and characterization of some new Schiff base ligands derived from various diamines and nitrosalicylaldehyde and their complexes of Ni(II) and Cu(II) are reported. Several spectral techniques such as UV-Vis, FT-IR, and NMR spectra were used to identify the chemical structures of the reported ligands and their complexes. The ligands are found to be bound to the metal atom through the oxygen atoms of the hydroxyl groups and nitrogen atoms of imine groups, which is also supported by spectroscopic techniques. The results obtained by FT-IR and NMR showed that the Schiff base complexes of transition metal (II) have square-planar geometry.

Synthesis Antimicrobial and Anticancer Activity of 1-[(arylalkylidene)amino]-3-(4H-1,2,4-triazol-4-yl)thiourea

2014 ◽  
Vol 1 (1) ◽  
pp. 5
Author(s):  
Umasankar Kulandaivelu ◽  
Bhawatha Chawada ◽  
Shireesha Boyapati ◽  
Alavala Rajasekhar Reddy
Keyword(s):  
Antibacterial Activity ◽  
Anticancer Activity ◽  
Cell Lines ◽  
Cancer Cell ◽  
Pathogenic Bacteria ◽  
Inhibitory Concentration ◽  
E Coli ◽  
Derivatives Of ◽  
Ht 29 ◽  
Better Than

Arylalkylidene derivatives of aminotriazoles (3a-3j) were synthesized and tested for their antimicrobial and anticancer activity. Four non-pathogenic bacteria [E. coli (NCIM 2068), K. pneumoniae (NCIM 2957), S. aureus (NCIM 2079), B. subtilis (NCIM 2921)] two fungi [C. albicans, A. niger] and two cancer cell lines [HBL-100 and HT-29] were employed in the study. All the compounds were found to have better antibacterial activity against B. subtilis than Ciprofloxacin (standard) and compound 3i was equivalent to Ciprofloxacin in inhibiting S. aureas. Similarly all the compounds inhibited the growth of A. niger better than Fluconazole and compound 3c was equivalent to Fluconazole (standard) in inhibiting C. albicans. In case of anticancer activity none of the molecule exhibited activity better than the standard used (Methotrexate), though they have inhibitory concentration at submicromolar level.

Microwave-Hydrothermal Synthesis and Characterization of Graphene

2012 ◽  
Vol 602-604 ◽  
pp. 917-920 ◽  
Author(s):  
Zhen Hui Xiao ◽  
Shui Sheng Wu ◽  
Yan Lin Sun ◽  
Yu Lin Zhao ◽  
Ya Ming Wang
Keyword(s):  
Chemical Reduction ◽  
Visible Spectrum ◽  
Synthesis And Characterization ◽  
X Ray Diffraction ◽  
X Ray ◽  
Microwave Hydrothermal ◽  
Ft Ir ◽  
Uv Visible ◽  
Scanning Electron

Graphene was synthesized by microwave-hydrothermal chemical reduction of graphite oxide using hydrazine hydrate as the reducing agent. Graphene was characterized using X-ray diffraction, UV-visible spectrum, FT-IR spectrum and scanning electron microscopy. Results indicated that the as-prepared graphene was wrinkled and comprised fewer graphenes with a highly crystalline structure.

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