ChemInform Abstract: Studies on the Nonmevalonate Pathway: Formation of 2-C-Methyl-D-erythritol 2,4-Cyclodiphosphate from 2-Phospho-4-(cytidine 5′-Diphospho)-2-C-methyl-D-erythritol.

ABSTRACT LytB and GcpE, because they are codistributed with other pathway enzymes, have been predicted to catalyze unknown steps in the nonmevalonate pathway for isoprenoid biosynthesis. We constructed a conditional Escherichia coli lytB mutant and found that LytB is essential for survival and that depletion of LytB results in cell lysis, which is consistent with a role for this protein in isoprenoid biosynthesis. Alcohols which can be converted to pathway intermediates beyond the hypothesized LytB step(s) support limited growth of E. coli lytB mutants. An informatic analysis of protein structure suggested that GcpE is a globular protein of the TIM barrel class and that LytB is also a globular protein. Possible biochemical roles for LytB and GcpE are suggested.

Download Full-text

Physiological requirements of the nonmevalonate pathway for photo-acclimation in Arabidopsis

Plant Biotechnology ◽

10.5511/plantbiotechnology.22.39 ◽

2005 ◽

Vol 22 (1) ◽

pp. 39-45 ◽

Cited By ~ 2

Author(s):

Masaya Hojo ◽

Masao Tasaka ◽

Toshiharu Shikanai

Keyword(s):

Nonmevalonate Pathway

Download Full-text

Chemical Basis of Nitrogen Recovery through the Ureide Pathway: Formation and Hydrolysis ofS-Ureidoglycine in Plants and Bacteria

ACS Chemical Biology ◽

10.1021/cb900248n ◽

2010 ◽

Vol 5 (2) ◽

pp. 203-214 ◽

Cited By ~ 28

Author(s):

Fabio Serventi ◽

Ileana Ramazzina ◽

Ilaria Lamberto ◽

Vincenzo Puggioni ◽

Rita Gatti ◽

...

Keyword(s):

Nitrogen Recovery ◽

Chemical Basis ◽

Pathway Formation

Download Full-text

Malformations of Cerebral Cortex Development: Molecules and Mechanisms

Annual Review of Pathology Mechanisms of Disease ◽

10.1146/annurev-pathmechdis-012418-012927 ◽

2019 ◽

Vol 14 (1) ◽

pp. 293-318 ◽

Cited By ~ 13

Author(s):

Gordana Juric-Sekhar ◽

Robert F. Hevner

Keyword(s):

Genetic Basis ◽

Focal Cortical Dysplasia ◽

Mammalian Target Of Rapamycin ◽

Sequencing Technologies ◽

Brain Anomalies ◽

Brain Malformations ◽

Pathway Formation ◽

Molecular Bases ◽

Cortical Progenitor ◽

Neuroimaging Techniques

Malformations of cortical development encompass heterogeneous groups of structural brain anomalies associated with complex neurodevelopmental disorders and diverse genetic and nongenetic etiologies. Recent progress in understanding the genetic basis of brain malformations has been driven by extraordinary advances in DNA sequencing technologies. For example, somatic mosaic mutations that activate mammalian target of rapamycin signaling in cortical progenitor cells during development are now recognized as the cause of hemimegalencephaly and some types of focal cortical dysplasia. In addition, research on brain development has begun to reveal the cellular and molecular bases of cortical gyrification and axon pathway formation, providing better understanding of disorders involving these processes. New neuroimaging techniques with improved resolution have enhanced our ability to characterize subtle malformations, such as those associated with intellectual disability and autism. In this review, we broadly discuss cortical malformations and focus on several for which genetic etiologies have elucidated pathogenesis.

Download Full-text