Syntheses and EGFR Kinase Inhibitory Activity of 6-Substituted-4-anilino [1,7] and [1,8] Naphthyridine-3-carbonitriles.

ChemInform ◽  
2004 ◽  
Vol 35 (30) ◽  
Author(s):  
Allan Wissner ◽  
Philip R. Hamann ◽  
Ramaswamy Nilakantan ◽  
Lee M. Greenberger ◽  
Fei Ye ◽  
...  
Keyword(s):  
Inhibitory Activity ◽  
Kinase Inhibitory Activity ◽  
Egfr Kinase

Syntheses and EGFR kinase inhibitory activity of 6-substituted-4-anilino [1,7] and [1,8] naphthyridine-3-carbonitriles

2004 ◽  
Vol 14 (6) ◽  
pp. 1411-1416 ◽  
Author(s):  
Allan Wissner ◽  
Philip R. Hamann ◽  
Ramaswamy Nilakantan ◽  
Lee M. Greenberger ◽  
Fei Ye ◽  
...  
Keyword(s):  
Inhibitory Activity ◽  
Kinase Inhibitory Activity ◽  
Egfr Kinase

Identification of new potent phthalazine derivatives with VEGFR-2 and EGFR kinase inhibitory activity

2016 ◽  
Vol 123 ◽  
pp. 191-201 ◽  
Author(s):  
Kamilia M. Amin ◽  
Flora F. Barsoum ◽  
Fadi M. Awadallah ◽  
Nehal E. Mohamed
Keyword(s):  
Inhibitory Activity ◽  
Kinase Inhibitory Activity ◽  
Egfr Kinase

scholarly journals Constituents of Acacia nilotica (L.) Delile with Novel Kinase Inhibitory Activity

2017 ◽  
Vol 4 (03) ◽  
pp. e108-e113 ◽  
Author(s):  
Augustine Ahmadu ◽  
Abdulkarim Agunu ◽  
Thi-Ngoc-Dung Nguyen ◽  
Blandine Baratte ◽  
Béatrice Foll-Josselin ◽  
...  
Keyword(s):  
Protein Kinases ◽  
Anticancer Agents ◽  
Inhibitory Activity ◽  
Ethyl Acetate Extract ◽  
Biological Activities ◽  
Bone Cancer ◽  
Acacia Nilotica ◽  
Tropical Africa ◽  
Ic50 Value ◽  
Kinase Inhibitory Activity

Abstract Acacia nilotica (L.) Delile belongs to the genus Acacia, which includes about 1400 species in subtropical and tropical Africa including Nigeria, Senegal, Egypt, and Mozambique as well as Asia from India to Burma. This plant is traditionally used to treat several pathologies such as mouth, ear, and bone cancer. Moreover, it possesses many other biological activities (antidiarrheal, anti-inflammatory, antimicrobial, and antifungal). We report here the extraction, purification, and identification of two known compounds [ethylgallate and (+)-catechin] from the bark of the tree that were further tested for their inhibitory activities against a panel of disease-related protein kinases. Both compounds were active, and (+)-catechin showed the best activity by inhibiting nine out of fourteen protein kinases with an IC50 value in the µg/mL range. This compound gave the highest activity against CLK1 with an IC50 of 2.1 µg/mL. The ethyl acetate extract and its components, such as catechins and other polyphenols, which also had protein kinase inhibitory activity, can be exploited in the research for anticancer agents.

Synthesis and kinase inhibitory activity of novel substituted indigoids

2009 ◽  
Vol 17 (17) ◽  
pp. 6257-6263 ◽  
Author(s):  
Anne Beauchard ◽  
Hélène Laborie ◽  
Hervé Rouillard ◽  
Olivier Lozach ◽  
Yoan Ferandin ◽  
...  
Keyword(s):  
Inhibitory Activity ◽  
Kinase Inhibitory Activity

Synthesis and RET protein kinase inhibitory activity of 3-arylureidobenzylidene-indolin-2-ones

2007 ◽  
Vol 17 (14) ◽  
pp. 3962-3968 ◽  
Author(s):  
Eleonora Rizzi ◽  
Giuliana Cassinelli ◽  
Sabrina Dallavalle ◽  
Cinzia Lanzi ◽  
Raffaella Cincinelli ◽  
...  
Keyword(s):  
Protein Kinase ◽  
Inhibitory Activity ◽  
Kinase Inhibitory Activity

scholarly journals Novel benzimidazole derivatives as anti-cervical cancer agents of potential multi-targeting kinase inhibitory activity

2020 ◽  
Vol 13 (12) ◽  
pp. 9179-9195
Author(s):  
Eman A. Abd El-Meguid ◽  
Eman M. Mohi El-Deen ◽  
Manal A. Nael ◽  
Manal M. Anwar
Keyword(s):  
Cervical Cancer ◽  
Inhibitory Activity ◽  
Benzimidazole Derivatives ◽  
Kinase Inhibitory Activity

O-Aryl α,β-d-ribofuranosides: Synthesis & highly efficient biocatalytic separation of anomers and evaluation of their Src kinase inhibitory activity

2012 ◽  
Vol 20 (23) ◽  
pp. 6821-6830 ◽  
Author(s):  
Raman K. Sharma ◽  
Sukhdev Singh ◽  
Rakesh Tiwari ◽  
Deendayal Mandal ◽  
Carl E. Olsen ◽  
...  
Keyword(s):  
Inhibitory Activity ◽  
Src Kinase ◽  
Highly Efficient ◽  
Kinase Inhibitory Activity
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