A Mild and Highly Efficient Protocol for the One-Pot Synthesis of Primary ?-Amino Phosphonates under Solvent-Free Conditions.

ChemInform ◽  
2005 ◽  
Vol 36 (13) ◽  
Author(s):  
Najmedin Azizi ◽  
Fatemeh Rajabi ◽  
Mohammad R. Saidi
2021 ◽  
Vol 76 (2) ◽  
pp. 85-90
Author(s):  
Abdolkarim Zare ◽  
Manije Dianat

Abstract A highly efficient and green protocol for the synthesis of pyrimido[4,5-b]quinolines has been described. The one-pot multicomponent reaction of dimedone with arylaldehydes and 6-amino-1,3-dimethyluracil in the presence of N,N-diethyl-N-sulfoethanaminium chloride ([Et3N–SO3H][Cl]) as an ionic liquid (IL) catalyst under solvent-free conditions afforded the mentioned compounds in high yields and short reaction times. Our protocol is superior to many of the reported protocols in terms of two or more of these factors: the reaction times, yields, conditions (solvent-free versus usage of organic solvents), temperature and catalyst amount.


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