In order to find an efficient catalytic system for Beckmann rearrangement of ketoximes, cyanuric chloride and Lewis acids were screened, and the cyanuric chloride /manganese chloride tetrahydrate system with good catalytic effect has been discovered. Using 2 mol% cyanuric chloride and 2 mol% MnCl2·4H2O as catalyst, the yield of Beckmann rearrangement of benzophenone oxime was 96% after refluxing for 2 h in acetonitrile. A variety of ketoximes underwent the Beckmann rearrangement to afford the corresponding amides in moderate to high yields.
Cyanuric Chloride as a Mild and Active Beckmann Rearrangement Catalyst.
