ChemInform Abstract: Arynes in Transition-Metal-Free Multicomponent Coupling Reactions

Multicomponent coupling reactions provide a method to combine several substrates in a single reaction. When coupled with transition-metal catalysis, these reactions can be used to both activate and control the assembly of multiple simple building blocks directly into useful products. This account will describe our work in this area, with a focus on the use of palladium catalysis as a tool to couple imines and CO with other substrates into a range of heterocyclic derivatives in one-step reactions.

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Metallaphotoredox Catalysis for Multicomponent Coupling Reactions

Green Chemistry ◽

10.1039/d1gc00993a ◽

2021 ◽

Author(s):

Wen-Jing Xiao ◽

Fu-Dong Lu ◽

Gui-Feng He ◽

Liang-Qiu Lu

Keyword(s):

Transition Metal ◽

Transition Metal Catalysis ◽

Coupling Reactions ◽

Complex Molecules ◽

Metal Catalysis ◽

Mild Conditions ◽

Multicomponent Coupling Reactions ◽

Multicomponent Coupling

The combination of photoredox and transition metal catalysis, which is termed metallaphotoredox catalysis, is a powerful platform for building complex molecules under mild conditions. In particular, metallaphotoredox-catalyzed multicomponent coupling reactions,...

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ChemInform Abstract: Transition-metal-catalyzed Multicomponent Coupling Reactions with Imines and Carbon Monoxide.

ChemInform ◽

10.1002/chin.201321250 ◽

2013 ◽

Vol 44 (21) ◽

pp. no-no

Author(s):

Jeffrey S. Quesnel ◽

Bruce A. Arndtsen

Keyword(s):

Carbon Monoxide ◽

Transition Metal ◽

Coupling Reactions ◽

Transition Metal Catalyzed ◽

Multicomponent Coupling Reactions ◽

Metal Catalyzed ◽

Multicomponent Coupling

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Catalytic bismetallative multicomponent coupling reactions: scope, applications, and mechanisms

Chemical Society Reviews ◽

10.1039/c3cs60482a ◽

2014 ◽

Vol 43 (13) ◽

pp. 4368-4380 ◽

Cited By ~ 39

Author(s):

Hee Yeon Cho ◽

James P. Morken

Keyword(s):

Transition Metal ◽

Functional Groups ◽

Metal Catalysts ◽

Transition Metal Catalysts ◽

Coupling Reactions ◽

Multicomponent Coupling Reactions ◽

Multicomponent Coupling

This review covers the bis-metallative coupling of unsaturated functional groups under the agency of transition metal catalysts.

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Enantioselective reductive multicomponent coupling reactions between isatins and aldehydes

Chemical Science ◽

10.1039/c5sc02170g ◽

2015 ◽

Vol 6 (11) ◽

pp. 6086-6090 ◽

Cited By ~ 39

Author(s):

Matthew A. Horwitz ◽

Naoya Tanaka ◽

Takuya Yokosaka ◽

Daisuke Uraguchi ◽

Jeffrey S. Johnson ◽

...

Keyword(s):

Reaction Mechanism ◽

Coupling Reactions ◽

Reductive Coupling ◽

Multicomponent Coupling Reactions ◽

Multicomponent Coupling

A reductive coupling of two different carbonyls via a polar two-electron reaction mechanism was developed and the stereochemical outcome of this multicomponent process is precisely controlled by a chiral triaminoiminophosphorane.

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Diiiodine/Potassium Persulfate Mediated Synthesis of 1,2,3-Thiadiazoles from N-Tosylhydrazones and a Thiocyanate Salt as a Sulfur Source under Transition-Metal-Free Conditions

Synlett ◽

10.1055/a-1473-7369 ◽

2021 ◽

Author(s):

Yadong Sun ◽

Ablimit Abdukader ◽

Yuhan Lu ◽

Chenjiang Liu

Keyword(s):

Transition Metal ◽

Efficient Method ◽

Room Temperature ◽

Functional Group ◽

Ammonium Thiocyanate ◽

Potassium Persulfate ◽

Sulfur Source ◽

Coupling Reactions ◽

Wide Scope ◽

Metal Free

AbstractA highly efficient method for the synthesis of 1,2,3-thiadiazoles has been developed by utilizing readily available tosylhydrazones and ammonium thiocyanate with ecofriendly EtOH as the solvent at room temperature. The reaction shows a wide scope of substrates and good functional-group tolerance. This protocol can be scaled up to a gram level and can be applied to coupling reactions with 4-(4-bromophenyl)-1,2,3-thiadiazole as the substrate.

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