ChemInform Abstract: Synthesis of Isoxazoline-Featured Oxindoles by Iminoxyl Radical-Promoted Cascade Oxyalkylation/Alkylarylation of Alkenes.

ChemInform ◽  
2016 ◽  
Vol 47 (24) ◽  
Author(s):  
Xiu-Long Yang ◽  
Yan Long ◽  
Fei Chen ◽  
Bing Han
Keyword(s):  
Iminoxyl Radical

Tyrosine-Selective Bioconjugation with Iminoxyl Radicals

2020 ◽  
Author(s):  
Katsuya Maruyama ◽  
Takashi Ishiyama ◽  
Yohei Seki ◽  
Kounosuke Oisaki ◽  
Motomu Kanai
Keyword(s):  
Reaction Time ◽  
Steric Hindrance ◽  
Room Temperature ◽  
Water Soluble ◽  
Light Irradiation ◽  
Sodium Ascorbate ◽  
Iminoxyl Radical ◽  
Short Reaction Time ◽  
Modified Peptides ◽  
The Stability

A novel Tyr-selective protein bioconjugation using the water-soluble persistent iminoxyl radical is described. The conjugation proceeded with high Tyr-selectivity and short reaction time under biocompatible conditions (room temperature in buffered media under air). The stability of the conjugates was tunable depending on the steric hindrance of iminoxyl. The presence of sodium ascorbate and/or light irradiation promoted traceless deconjugation, restoring the native Tyr structure. The method is applied to the synthesis of a protein-dye conjugate and further derivatization to azobenzene-modified peptides.

ChemInform Abstract: Iminoxyl Radical-Based Strategy for Intermolecular C-O Bond Formation: Cross-Dehydrogenative Coupling of 1,3-Dicarbonyl Compounds with Oximes.

ChemInform ◽  
2014 ◽  
Vol 45 (51) ◽  
pp. no-no
Author(s):  
Igor B. Krylov ◽  
Alexander O. Terent'ev ◽  
Vladimir P. Timofeev ◽  
Boris N. Shelimov ◽  
Roman A. Novikov ◽  
...  
Keyword(s):  
Bond Formation ◽  
Iminoxyl Radical ◽  
Dicarbonyl Compounds ◽  
Dehydrogenative Coupling

scholarly journals Nitric Oxide Trapping of the Tyrosyl Radical of Prostaglandin H Synthase-2 Leads to Tyrosine Iminoxyl Radical and Nitrotyrosine Formation

1997 ◽  
Vol 272 (27) ◽  
pp. 17086-17090 ◽  
Author(s):  
Michael R. Gunther ◽  
Linda C. Hsi ◽  
John F. Curtis ◽  
James K. Gierse ◽  
Lawrence J. Marnett ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Tyrosyl Radical ◽  
Iminoxyl Radical ◽  
Prostaglandin H Synthase ◽  
Prostaglandin H

scholarly journals Affinity modification of cytochrome P450 by iodine-containing stable iminoxyl radical

FEBS Letters ◽  
1980 ◽  
Vol 115 (1) ◽  
pp. 31-34 ◽  
Author(s):  
V.V. Lyakhovich ◽  
N.E. Polyakova ◽  
V.I. Popova ◽  
S.I. Eremenko ◽  
S.E. Olkin ◽  
...  
Keyword(s):  
Cytochrome P450 ◽  
Iminoxyl Radical ◽  
Affinity Modification

Iminoxyl Radical-Based Strategy for Intermolecular CO Bond Formation: Cross-Dehydrogenative Coupling of 1,3-Dicarbonyl Compounds with Oximes

2014 ◽  
Vol 356 (10) ◽  
pp. 2266-2280 ◽  
Author(s):  
Igor B. Krylov ◽  
Alexander O. Terent'ev ◽  
Vladimir P. Timofeev ◽  
Boris N. Shelimov ◽  
Roman A. Novikov ◽  
...  
Keyword(s):  
Bond Formation ◽  
Iminoxyl Radical ◽  
Dicarbonyl Compounds ◽  
Dehydrogenative Coupling
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