Enantioseparation of mandelic acid and substituted derivatives by high‐performance liquid chromatography with hydroxypropyl‐β‐cyclodextrin as chiral mobile additive and evaluation of inclusion complexes by molecular dynamics

Chirality ◽  
2021 ◽  
Author(s):  
Jie‐Hua Shi ◽  
Zhen‐Yi Lin ◽  
Song‐Bo Kou ◽  
Bao‐Li Wang ◽  
Shao‐Liang Jiang
Keyword(s):  
Molecular Dynamics ◽  
High Performance Liquid Chromatography ◽  
Liquid Chromatography ◽  
Inclusion Complexes ◽  
High Performance ◽  
Mandelic Acid

scholarly journals Determination of the stability constants for inclusion complexes of cyclodextrins with various drug molecules by high performance liquid chromatography.

1978 ◽  
Vol 26 (11) ◽  
pp. 3477-3484 ◽  
Author(s):  
KANETO UEKAMA ◽  
FUMITOSHI HIRAYAMA ◽  
SHOUZO NASU ◽  
NAOKI MATSUO ◽  
TETSUMI IRIE
Keyword(s):  
High Performance Liquid Chromatography ◽  
Liquid Chromatography ◽  
Inclusion Complexes ◽  
Stability Constants ◽  
High Performance ◽  
Drug Molecules ◽  
The Stability

scholarly journals Photostability of Loratadine Inclusion Complexes with Natural Cyclodextrins

2015 ◽  
Vol 2015 ◽  
pp. 1-6 ◽  
Author(s):  
Patricia Elizabeth Rivas-Granizo ◽  
Leandro Giorgetti ◽  
Humberto Gomes Ferraz
Keyword(s):  
Thermal Analysis ◽  
High Performance Liquid Chromatography ◽  
Liquid Chromatography ◽  
Statistical Analysis ◽  
Inclusion Complexes ◽  
Active Ingredient ◽  
High Performance ◽  
Full Recovery ◽  
Stoichiometric Ratios ◽  
Histamine Antagonist

The purpose of this study was to evaluate the photostability of inclusion complexes of the histamine antagonist loratadine (LORA) withα-,β-, andγ-cyclodextrins (CDs). Accordingly, binary drug-CD complexes were prepared using the coevaporation method at 1 : 1, 1 : 2, and 1 : 3 stoichiometric ratios, which were characterized by thermal analysis. Subsequently, solutions of the complexes at 500 μg mL−1in HCl 0.1 M were subjected to irradiation in a photostability chamber for 12 hours, and the content of the remaining active ingredient was quantified by means of high-performance liquid chromatography. It is possible to observe the presence of two products originating from photodegradation (P1 and P2), which were identified in solutions of loratadine withα- andβ-CD. By means of statistical analysis, we conclude that the drug:α-CD and drug:γ-CD (1 : 1) complexes proved to be more efficient in the photostability assay, obtaining a nonsignificant level of degradation and full recovery of LORA.

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