Purification of rutin by supercritical fluid simulated moving bed chromatography

Author(s):  
Zhongfeng Geng ◽  
Yuzhu Yang ◽  
Shuyuan Yang ◽  
Jinyi Zhou ◽  
Huisheng Lyu

2005 ◽  
Vol 1092 (1) ◽  
pp. 55-64 ◽  
Author(s):  
Arvind Rajendran ◽  
Stephanie Peper ◽  
Monika Johannsen ◽  
Marco Mazzotti ◽  
Massimo Morbidelli ◽  
...  


1997 ◽  
Vol 786 (2) ◽  
pp. 309-320 ◽  
Author(s):  
Marco Mazzotti ◽  
Giuseppe Storti ◽  
Massimo Morbidelli




2001 ◽  
Vol 919 (1) ◽  
pp. 1-12 ◽  
Author(s):  
Orazio Di Giovanni ◽  
Marco Mazzotti ◽  
Massimo Morbidelli ◽  
Félicie Denet ◽  
Willy Hauck ◽  
...  


2002 ◽  
Vol 37 (11) ◽  
pp. 2545-2566 ◽  
Author(s):  
S. Peper ◽  
M. Lübbert ◽  
M. Johannsen ◽  
G. Brunner


Molecules ◽  
2021 ◽  
Vol 26 (2) ◽  
pp. 468
Author(s):  
Yiwen Yang ◽  
Yehui Wang ◽  
Zongbi Bao ◽  
Qiwei Yang ◽  
Zhiguo Zhang ◽  
...  

β-adrenergic antagonists (β-blockers) with at least one chiral center are an exceedingly important class of drugs used mostly to treat cardiovascular diseases. At least 70 β-blockers have been investigated in history. However, only a few β-blockers, e.g., timolol, are clinically marketed as an optically pure enantiomer. Therefore, the separation of racemates of β-blockers is essential both in the laboratory and industry. Many approaches have been explored to obtain the single enantiomeric β-blocker, including high performance liquid chromatography, supercritical fluid chromatography and simulated moving bed chromatography. In this article, a review is presented on different chromatographic methods applied for the enantioseparation of β-blockers, covering high performance liquid chromatography (HPLC), supercritical fluid chromatography (SFC) and simulated moving bed chromatography (SMB).





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