Discovery, Synthesis, and in vitro Evaluation of West Nile Virus Protease Inhibitors Based on the 9,10-Dihydro-3H,4aH-1,3,9,10a-tetraazaphenanthren-4-one Scaffold

ChemMedChem ◽  
2012 ◽  
Vol 7 (7) ◽  
pp. 1210-1216 ◽  
Author(s):  
Sanjay Samanta ◽  
Taian Cui ◽  
Yulin Lam
Keyword(s):  
West Nile Virus ◽  
Protease Inhibitors ◽  
West Nile ◽  
In Vitro Evaluation

scholarly journals In Vitro Evaluation of the Protective Role of Human Antibodies to West Nile Virus (WNV) Produced during Natural WNV Infection

2008 ◽  
Vol 198 (9) ◽  
pp. 1300-1308 ◽  
Author(s):  
M. Rios ◽  
S. Daniel ◽  
A. I. Dayton ◽  
O. Wood ◽  
I. K. Hewlett ◽  
...  
Keyword(s):  
West Nile Virus ◽  
Protective Role ◽  
West Nile ◽  
In Vitro Evaluation ◽  
Human Antibodies

scholarly journals The recently identified flavivirus Bamaga virus is transmitted horizontally by Culex mosquitoes and interferes with West Nile virus replication in vitro and transmission in vivo

2018 ◽  
Vol 12 (10) ◽  
pp. e0006886 ◽  
Author(s):  
Agathe M. G. Colmant ◽  
Sonja Hall-Mendelin ◽  
Scott A. Ritchie ◽  
Helle Bielefeldt-Ohmann ◽  
Jessica J. Harrison ◽  
...  
Keyword(s):  
West Nile Virus ◽  
Virus Replication ◽  
West Nile ◽  
Culex Mosquitoes

scholarly journals In Vitro Analysis of Myd88-mediated Cellular Immune Response to West Nile Virus Mutant Strain Infection

10.3791/52121 ◽  
2014 ◽  
Author(s):  
Guorui Xie ◽  
Melissa C. Whiteman ◽  
Jason A. Wicker ◽  
Alan D.T. Barrett ◽  
Tian Wang
Keyword(s):  
Immune Response ◽  
West Nile Virus ◽  
Mutant Strain ◽  
Cellular Immune Response ◽  
West Nile ◽  
Virus Mutant ◽  
Cellular Immune

scholarly journals Extinction of West Nile Virus by Favipiravir through Lethal Mutagenesis

2017 ◽  
Vol 61 (11) ◽  
Author(s):  
Estela Escribano-Romero ◽  
Nereida Jiménez de Oya ◽  
Esteban Domingo ◽  
Juan Carlos Saiz
Keyword(s):  
West Nile Virus ◽  
Mutation Frequency ◽  
Ebola Virus ◽  
Rna Viruses ◽  
Lethal Dose ◽  
Antiviral Agent ◽  
West Nile ◽  
Lethal Mutagenesis ◽  
Mutant Spectrum

ABSTRACT Favipiravir is an antiviral agent effective against several RNA viruses. The drug has been shown to protect mice against experimental infection with a lethal dose of West Nile virus (WNV), a mosquito-borne flavivirus responsible for outbreaks of meningitis and encephalitis for which no antiviral therapy has been licensed; however, the mechanism of action of the drug is still not well understood. Here, we describe the potent in vitro antiviral activity of favipiravir against WNV, showing that it decreases virus-specific infectivity and drives the virus to extinction. Two passages of WNV in the presence of 1 mM favipiravir—a concentration that is more than 10-fold lower than its 50% cytotoxic concentration (CC50)—resulted in a significant increase in mutation frequency in the mutant spectrum and in a bias toward A→G and G→A transitions relative to the population passaged in the absence of the drug. These data, together with the fact that the drug is already licensed in Japan against influenza virus and in a clinical trial against Ebola virus, point to favipiravir as a promising antiviral agent to fight medically relevant flaviviral infections, such as that caused by WNV.

scholarly journals Human Monoclonal Fab Antibodies Against West Nile Virus and its Neutralizing Activity Analyzed in Vitro and in Vivo

2009 ◽  
Vol 01 (01) ◽  
pp. 036-042 ◽  
Author(s):  
Tao Duan ◽  
Monique Ferguson ◽  
Lintian Yuan ◽  
Fangling Xu ◽  
Guangyu Li
Keyword(s):  
West Nile Virus ◽  
West Nile ◽  
Neutralizing Activity
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