In Vivo Evaluation of Selective Carbonic Anhydrase Inhibitors as Potential Anticonvulsant Agents

ChemMedChem ◽  
2016 ◽  
Vol 11 (16) ◽  
pp. 1812-1818 ◽  
Author(s):  
Elvira Bruno ◽  
Maria R. Buemi ◽  
Laura De Luca ◽  
Stefania Ferro ◽  
Anna-Maria Monforte ◽  
...  
Keyword(s):  
Carbonic Anhydrase ◽  
In Vivo Evaluation ◽  
Carbonic Anhydrase Inhibitors ◽  
Anticonvulsant Agents

Discovery of potent anti-convulsant carbonic anhydrase inhibitors: Design, synthesis, in vitro and in vivo appraisal

2018 ◽  
Vol 156 ◽  
pp. 430-443 ◽  
Author(s):  
Chandra Bhushan Mishra ◽  
Shikha Kumari ◽  
Andrea Angeli ◽  
Silvia Bua ◽  
Martina Buonanno ◽  
...  
Keyword(s):  
Carbonic Anhydrase ◽  
Carbonic Anhydrase Inhibitors ◽  
Design Synthesis

scholarly journals Carbonic anhydrase inhibition for the management of cerebral ischemia: in vivo evaluation of sulfonamide and coumarin inhibitors

2015 ◽  
Vol 31 (6) ◽  
pp. 894-899 ◽  
Author(s):  
Lorenzo Di Cesare Mannelli ◽  
Laura Micheli ◽  
Fabrizio Carta ◽  
Andrea Cozzi ◽  
Carla Ghelardini ◽  
...  
Keyword(s):  
Cerebral Ischemia ◽  
Carbonic Anhydrase ◽  
In Vivo Evaluation ◽  
Carbonic Anhydrase Inhibition

scholarly journals A CRITICAL EVALUATION OF THE HISTOCHEMICAL METHODS FOR CARBONIC ANHYDRASE

1972 ◽  
Vol 20 (5) ◽  
pp. 319-330 ◽  
Author(s):  
THOMAS F. MUTHER
Keyword(s):  
Enzyme Activity ◽  
Surface Layer ◽  
Carbonic Anhydrase ◽  
Sodium Lauryl Sulfate ◽  
Critical Evaluation ◽  
Lauryl Sulfate ◽  
Carbonic Anhydrase Inhibitors ◽  
Histochemical Methods ◽  
Rate Limiting

The histochemical methods for carbonic anhydrase are not based on the postulated dehydration of HCO3–. The staining is caused by the formation of an unknown reactive Co compound in the surface layer secondary to enzyme-independent alkalinization of the medium. Kinetic analysis of the reaction shows that loss of CO2 from the medium is rate-limiting. Carbonic anhydrase inhibitors delay the staining by interacting with Co and not by inhibiting the enzyme; they are effective when used after the reaction is complete. The reaction can also be inhibited by agents which are not carbonic anhydrase inhibitors, such as sodium lauryl sulfate and 5-aminothiadiazole, but not by in vivo administered acetazolamide. A comparison of the effect of various fixatives on the biochemical and histochemical enzyme activity shows no correlation. While carbonic anhydrase itself is stained by the reaction, the methods lack the claimed specificity for it.

Carbonic Anhydrase Inhibitors as Anticonvulsant Agents

2007 ◽  
Vol 7 (9) ◽  
pp. 855-864 ◽  
Author(s):  
Anne Thiry ◽  
Jean-Michel Dogne ◽  
Claudiu Supuran ◽  
Bernard Masereel
Keyword(s):  
Carbonic Anhydrase ◽  
Carbonic Anhydrase Inhibitors ◽  
Anticonvulsant Agents

Drug Design of Carbonic Anhydrase Inhibitors as Anticonvulsant Agents

2009 ◽  
pp. 171-191
Author(s):  
Anne Thiry ◽  
Jean-Michel Dogn ◽  
Claudiu T. Supuran ◽  
Bernard Masereel
Keyword(s):  
Drug Design ◽  
Carbonic Anhydrase ◽  
Carbonic Anhydrase Inhibitors ◽  
Anticonvulsant Agents

scholarly journals Carbonic Anhydrase Inhibitors suppress platelet procoagulant responses and in vivo thrombosis

Platelets ◽  
2020 ◽  
Vol 31 (7) ◽  
pp. 853-859 ◽  
Author(s):  
Ejaife O. Agbani ◽  
Xiaojuan Zhao ◽  
Christopher M. Williams ◽  
Riyaad Aungraheeta ◽  
Ingeborg Hers ◽  
...  
Keyword(s):  
Carbonic Anhydrase ◽  
Carbonic Anhydrase Inhibitors
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