Development of Therapeutic Gramicidin S Analogues Bearing Plastic β,γ‐Diamino Acids

ChemMedChem ◽  
2020 ◽  
Vol 15 (12) ◽  
pp. 1089-1100 ◽  
Author(s):  
Qinkun Guan ◽  
Kaisen Chen ◽  
Qiang Chen ◽  
Jianguo Hu ◽  
Keguang Cheng ◽  
...  
Keyword(s):  
Gramicidin S

Both D-phenylalanine and Proline Keep the Type II' β-turn During Thermocyclization of Linear Gramicidin S Precursor Analogues

2014 ◽  
Vol 11 (4) ◽  
pp. 313-316
Author(s):  
Hai-Qiang Wu ◽  
Xiao-Ru Zhang ◽  
Xiao-Bing Li ◽  
Lian-Quan Gu ◽  
Lin-Kun An
Keyword(s):  
Type Ii ◽  
Gramicidin S

scholarly journals Intracellular serine proteinase of Bacillus subtilis strain Marburg 168. Comparison with the homologous enzyme from Bacillus subtilis strain A-50

1979 ◽  
Vol 179 (2) ◽  
pp. 333-339 ◽  
Author(s):  
A Y Strongin ◽  
D I Gorodetsky ◽  
I A Kuznetsova ◽  
V V Yanonis ◽  
Z T Abramov ◽  
...  
Keyword(s):  
Bacillus Subtilis ◽  
Serine Proteinase ◽  
Subtilis Strain ◽  
Bacterial Strains ◽  
Terminal Sequence ◽  
Gramicidin S ◽  
Intracellular Enzymes ◽  
Sepharose 4B ◽  
Homologous Enzyme ◽  
Strict Selection

Intracellular serine proteinase was isolated from sporulating cells of Bacillus subtilis Marburg 168 by gramicidin S-Sepharose 4B affinity chromatography. The enzymological characteristics, the amino acid composition and the 19 residues of the N-terminal sequence of the enzyme are reported. The isolated proteinase was closely related to, but not completely identical with, the intracellular serine proteinase of B. subtilis A-50. The divergence between these two intracellular enzymes was less than that between the corresponding extracellular serine proteinases (subtilisins) of types Carlsberg and BPN′!, produced by these bacterial strains. This may be connected with the more strict selection constraints imposed in intracellular enzymes during evolution.

scholarly journals An active serine is involved in covalent substrate amino acid binding at each reaction center of gramicidin S synthetase.

1991 ◽  
Vol 266 (34) ◽  
pp. 23135-23141 ◽  
Author(s):  
W. Schlumbohm ◽  
T. Stein ◽  
C. Ullrich ◽  
J. Vater ◽  
M. Krause ◽  
...  
Keyword(s):  
Amino Acid ◽  
Reaction Center ◽  
Gramicidin S ◽  
Amino Acid Binding

The Correlation between Conformation and Biological Activity of Gramicidin S Analogs

1970 ◽  
Vol 68 (5) ◽  
pp. 751-753 ◽  
Author(s):  
Tetsuo KATO ◽  
Michinori WAKI ◽  
Shuji MATSUURA ◽  
Nobuo IZUMIYA
Keyword(s):  
Biological Activity ◽  
Gramicidin S

scholarly journals Similarity of Gramicidin S and Cryoprotectant Polyethylene Glycol Membranotropic Effects

2019 ◽  
Vol 29 (2) ◽  
pp. 161-161
Author(s):  
Viacheslav Kalinovych ◽  
◽  
Volodymyr Berest ◽  
Keyword(s):  
Polyethylene Glycol ◽  
Gramicidin S

Further studies on the role of phenylalanine in gramicidin S biosynthesis by Bacillus brevis

1984 ◽  
Vol 1 (2) ◽  
pp. 81-94 ◽  
Author(s):  
J.-H. David Wu ◽  
Linda Yang ◽  
Arnold L. Demain
Keyword(s):  
Bacillus Brevis ◽  
Gramicidin S
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