A Comprehensive Overview of Structure‐Activity Relationships of Small‐Molecule Splicing Modulators Targeting SF3B1 as Anticancer Agents

ChemMedChem ◽  
2020 ◽  
Vol 15 (22) ◽  
pp. 2098-2120
Author(s):  
Datong Zhang ◽  
Fancui Meng
Keyword(s):  
Small Molecule ◽  
Anticancer Agents ◽  
Comprehensive Overview ◽  
Structure Activity Relationships ◽  
Structure Activity

Design, synthesis and biological activities of pyrrole-3-carboxamide derivatives as EZH2 (enhancer of zeste homologue 2) inhibitors and anticancer agents

2020 ◽  
Vol 44 (6) ◽  
pp. 2247-2255
Author(s):  
Qifan Zhou ◽  
Lina Jia ◽  
Fangyu Du ◽  
Xiaoyu Dong ◽  
Wanyu Sun ◽  
...  
Keyword(s):  
Biological Activity ◽  
Anticancer Agents ◽  
Biological Activities ◽  
Activity Assay ◽  
Design Synthesis ◽  
Structure Activity Relationships ◽  
Structure Activity ◽  
Enhancer Of Zeste

A novel series of pyrrole-3-carboxamides targeting EZH2 have been designed and synthesized. The structure–activity relationships were summarized by combining with in vitro biological activity assay and docking results.

5-Cinnamoyl-6-aminouracil derivatives as novel anticancer agents. Synthesis, biological evaluation, and structure-activity relationships

1985 ◽  
Vol 28 (4) ◽  
pp. 497-502 ◽  
Author(s):  
Jean Luc Bernier ◽  
Jean Pierre Henichart ◽  
Vincent Warin ◽  
Chantal Trentesaux ◽  
Jean Claude Jardillier
Keyword(s):  
Anticancer Agents ◽  
Biological Evaluation ◽  
Structure Activity Relationships ◽  
Structure Activity
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