CMR 2005: 8.02: Fibrin-directed nanoparticles for combined imaging and local thrombolytic therapy

SummaryTranscatheter local thrombolytic therapy in patients with acute, extended splanchnic venous thrombosis is controversial. Here we present our single-center experience with transcatheter thrombolytic therapy in these patients. All consecutive patients (n=12) with acute,extended splanchnic venous thrombosis who underwent transcatheter thrombolytic therapy in our hospital, were included in this study. Thrombolytic therapy was successful for three thrombotic events and partially successful for four thrombotic events.Two patients developed minor procedure-related bleeding (17%).Six patients (50%) developed major procedure-related bleeding, with a fatal outcome in two. Transcatheter thrombolytic therapy in patients with acute, extended splanchnic vein thrombosis is found to be associated with a high rate of procedure-related bleeding. Therefore, thrombolysis should be reserved for patients in whom the venous flow cannot be restored by using conventional anticoagulant therapy or stent placement across the thrombosed vessel segment.H.L.A. Janssen and F.W.G. Leebeek are both Clinical Fellows of the Netherlands Organisation for Scientific Research (NWO).

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Local Thrombolytic Therapy for Cere-brovascular Disease: Current Oregon Health Sciences University Experience (July 1991 through April 1995)

Journal of Vascular and Interventional Radiology ◽

10.1016/s1051-0443(95)71253-2 ◽

1995 ◽

Vol 6 (6) ◽

pp. 78S-82S ◽

Cited By ~ 11

Author(s):

Stanley L. Barnwell ◽

Gary M. Nesbit ◽

Wayne M. Clark

Keyword(s):

Thrombolytic Therapy ◽

Health Sciences ◽

Oregon Health ◽

Local Thrombolytic Therapy ◽

University Experience

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Arterial thrombotic occlusions following percutaneous catheterization in infants and children: local thrombolytic therapy with urokinase

Journal of the Korean Radiological Society ◽

10.3348/jkrs.1992.28.6.977 ◽

1992 ◽

Vol 28 (6) ◽

pp. 977

Author(s):

Yong Joo Kim

Keyword(s):

Thrombolytic Therapy ◽

Infants And Children ◽

Percutaneous Catheterization ◽

Local Thrombolytic Therapy ◽

In Infants And Children

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D-Dimer in Local Thrombolytic Therapy with Low Doses of Recombinant Human Tissue-Type Plasminogen Activator (rt-PA) in Patients with Peripheral Arterial Occlusive Disease

Thrombosis and Haemostasis ◽

10.1055/s-0038-1647283 ◽

1990 ◽

Vol 64 (02) ◽

pp. 192-195 ◽

Cited By ~ 4

Author(s):

Renate Koppensteiner ◽

Wolfgang Speiser ◽

Erich Minar ◽

Ramazan Ahmadi ◽

Herbert Ehringer

Keyword(s):

Thrombolytic Therapy ◽

Plasminogen Activator ◽

Human Tissue ◽

Tissue Type ◽

Low Doses ◽

Tissue Type Plasminogen Activator ◽

Type Plasminogen Activator ◽

Local Thrombolytic Therapy ◽

Peripheral Arterial ◽

D Dimer

SummaryThe generation of D-dimer was studied in the course of local thrombolytic therapy of peripheral arterial occlusions with low doses of recombinant human tissue-type plasminogen activator (rt-PA) in 7 patients. Intermittent local application of rt-PA resulted in a marked increase in D-dimer exceeding values usually seen after intravenous application of manifold higher doses used in myocardial infarction. The increase in D-dimer was related to the estimated thrombus size (length of the occlusion) and the total dose of rt-PA applied. During local rt-PA infusion 6 of 7 patients maintained plasminogen activator inhibitor capacity (PAI-cap) between 34% and 79% of their corresponding pre-treatment levels; detectable levels of PAI-cap in circulating blood during the procedure did not interfere with the success of therapy.

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