p63 expression of clear myoepithelial cells in epithelial-myoepithelial carcinoma of the salivary gland

Epithelial-myoepithelial carcinomas comprise approximately 1 % of all salivary gland neoplasms. They are preponderantly tumors of the parotid glands with a relatively low mortality but a decided locoregional aggressiveness. Histopathologically, the carcinomas are characterized by a dual cell population of epithelial (ductal) cells and myoepithelial cells. These cells vary in their dominance and phenotypic expression

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Cytological features of epithelial-myoepithelial carcinoma of the salivary gland-relationship of intercalated duct-like cells and clear myoepithelial cells-

The Journal of the Japanese Society of Clinical Cytology ◽

10.5795/jjscc.45.50 ◽

2006 ◽

Vol 45 (1) ◽

pp. 50-54

Author(s):

Akihiko KAWAHARA ◽

Hiroshi HARADA ◽

Toshiro YOKOYAMA ◽

Masayoshi KAGE

Keyword(s):

Salivary Gland ◽

Myoepithelial Cells ◽

Myoepithelial Carcinoma ◽

Cytological Features ◽

Epithelial Myoepithelial Carcinoma ◽

Relationship Of

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Epithelial-Myoepithelial Carcinoma of the Salivary Gland

Philippine Journal of Otolaryngology Head and Neck Surgery ◽

10.32412/pjohns.v28i1.507 ◽

2013 ◽

Vol 28 (1) ◽

pp. 36-37

Author(s):

Jose M. Carnate ◽

José Florencio F. Lapeña

Keyword(s):

Salivary Gland ◽

Cell Types ◽

Myoepithelial Cells ◽

World Health ◽

Low Grade ◽

Myoepithelial Carcinoma ◽

S 100 ◽

Grade Malignancy ◽

Epithelial Myoepithelial Carcinoma ◽

Health Organization

The World Health Organization (2005) defines an epithelial-myoepithelial carcinoma (EMC) as a malignancy composed of two cell types that typically form duct-like structures.1 We present herein an archival case from the parotid gland. EMC occurs primarily in the major salivary glands particularly in the parotid where it presents as a painless, slow-growing mass.1 Microscopic examination shows bi-layered tubular duct-like structures with pale to clear areas (Figure 1). The inner luminal layer is composed of cuboidal cells that are of epithelial derivation while the outer layer is composed of polygonal cells that are of myoepithelial derivation (Figures 2 and 3). The latter typically have abundant clear cytoplasm.1,2 The epithelial-myoepithelial dualism is confirmed using immunohistochemical stains; the epithelial cells being immunoreactive for low molecular weight keratin and the myoepithelial cells for S-100 protein, muscle specific actin, vimentin and p63.1, 3 EMC is primarily a tumor of adulthood with peak incidence in the sixth and seventh decades. First described by Donath et al. in 1972,3 they are rare salivary gland neoplasms with an incidence of less than 1% arising mainly in the parotid gland4 although they have been documented in the lungs.5 Perineural and vascular invasion are frequent and recurrence occurs in around 40% of cases and metastasis in 14%.1 Although thought to be of low-grade malignancy, fatal courses have been described4 and “analysis of the various series have demonstrated that tumors with a solid growing pattern, nuclear atypia, DNA aneuploidy and high proliferative activity, generally have a more aggressive behavior and a higher frequency of local recurrences and metastases.”3

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Ki-67 Index in Salivary Gland Neoplasms

International Journal of Phonosurgery & Laryngology ◽

10.5005/jp-journals-10023-1110 ◽

2016 ◽

Vol 6 (1) ◽

pp. 1-7

Author(s):

Suma Kaza ◽

T Jaya Mastan Rao ◽

Anupama Mikkilineni ◽

G Venkata Ratnam ◽

D Ranga Rao

Keyword(s):

Salivary Gland ◽

Pleomorphic Adenoma ◽

Mucoepidermoid Carcinoma ◽

Salivary Gland Neoplasms ◽

Carcinoma Ex Pleomorphic Adenoma ◽

Myoepithelial Carcinoma ◽

Cell Adenoma ◽

Ki 67 ◽

Adenoid Cystic ◽

Epithelial Myoepithelial Carcinoma

Abstract Assessment of proliferation is a means of predicting local recurrence and metastatic potential of malignancies. A mitotic count is not an ideal marker for proliferation in certain situations, such as salivary gland neoplasms. Ki-67 expression as a proliferation marker has been investigated in many human tumors. In the present study, Mitotic index (MI) and Ki-67 index were studied in pleomorphic adenoma, basal cell adenoma, mucoepidermoid carcinoma, adenoid cystic carcinoma epithelial myoepithelial carcinoma, carcinoma ex Pleomorphic adenoma and adenocarcinoma of salivary glands. The results were compared. The MI was similar in benign neoplasms, mucoepidermoid carcinoma and epithelial myoepithelial carcinoma, whereas it was high in carcinoma ex pleomorphic adenoma, adenocarcinoma and adenoid cystic carcinoma. The Ki-67 index was different in basal cell adenoma and pleomorphic adenoma. It was helpful in differentiating high grade and low grade mucoepidermoid carcinoma. It highlighted the malignant behavior of epithelial myoepithelial carcinoma. It was concluded that Ki-67 in benign neoplasms is 5% or less and in malignant ones more than 23% with a few exceptions. In mucoepidermoid carcinoma and epithelial myoepithelial carcinoma, Ki-67 index was found to be a better indicator for aggressiveness. These findings will be presented in this paper, with review of literature. How to cite this article Kaza S, Rao TJM, Mikkilineni A, Ratnam GV, Rao DR. Ki-67 Index in Salivary Gland Neoplasms. Int J Phonosurg Laryngol 2016;6(1):1-7.

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