Chronic nerve compression injury induces a phenotypic switch of neurons within the dorsal root ganglia

2007 ◽  
Vol 506 (2) ◽  
pp. 180-193 ◽  
Author(s):  
Tom Chao ◽  
Khoa Pham ◽  
Oswald Steward ◽  
Ranjan Gupta
Keyword(s):  
Dorsal Root Ganglia ◽  
Dorsal Root ◽  
Nerve Compression ◽  
Compression Injury ◽  
Phenotypic Switch ◽  
Chronic Nerve Compression ◽  
Nerve Compression Injury

Systematic investigation and comparison of US FDA-approved immunosuppressive drugs FK506, cyclosporine and rapamycin for neuromuscular regeneration following chronic nerve compression injury

2021 ◽  
Vol 16 (11) ◽  
pp. 989-1003
Author(s):  
Lucas Degrugillier ◽  
Katharina M Prautsch ◽  
Dirk J Schaefer ◽  
Raphael Guzman ◽  
Daniel F Kalbermatten ◽  
...  
Keyword(s):  
Dorsal Root Ganglia ◽  
Dorsal Root ◽  
Nerve Compression ◽  
In Vivo Model ◽  
Compression Injury ◽  
Potent Effect ◽  
Therapeutic Benefits ◽  
Chronic Nerve Compression

Aim: To compare therapeutic benefits of different immunophilin ligands for treating nerve injuries. Materials & methods: Cyclosporine, FK506 and rapamycin, were evaluated first in vitro on a serum-free culture of embryonic dorsal root ganglia followed by a new in vivo model of chronic nerve compression. Results: Outcomes of the in vitro study have shown a potent effect of cyclosporine and FK506, on dorsal root ganglia axonal outgrowth, comparable to the effect of nerve growth factor. Rapamycin exhibited only a moderate effect. The in vivo study revealed the beneficial effects of cyclosporine, FK506 and rapamycin for neuromuscular regeneration. Cyclosporine showed the better maintenance of the tissues and function. Conclusion: Cyclosporine, FK506 and rapamycin drugs showed potential for treating peripheral nerve chronic compression injuries.

scholarly journals Neuromuscular junction integrity after chronic nerve compression injury

2009 ◽  
Vol 27 (1) ◽  
pp. 114-119 ◽  
Author(s):  
Tahseen Mozaffar ◽  
Erika Strandberg ◽  
Kazuko Abe ◽  
Lutz G. Hilgenberg ◽  
Martin A. Smith ◽  
...  
Keyword(s):  
Neuromuscular Junction ◽  
Nerve Compression ◽  
Compression Injury ◽  
Chronic Nerve Compression ◽  
Nerve Compression Injury
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