Differential effects of experimental glaucoma on intrinsically photosensitive retinal ganglion cells in mice

2021 ◽  
Author(s):  
Jingyi Gao ◽  
Erin M. Griner ◽  
Mingna Liu ◽  
Joanna Moy ◽  
Ignacio Provencio ◽  
...  
Keyword(s):  
Retinal Ganglion Cells ◽  
Ganglion Cells ◽  
Retinal Ganglion ◽  
Differential Effects ◽  
Experimental Glaucoma

Neuroprotective effect of the somatostatin receptor 5 agonist L-817,818 on retinal ganglion cells in experimental glaucoma

2021 ◽  
Vol 204 ◽  
pp. 108449
Author(s):  
Yi Zhang ◽  
Na Wu ◽  
Qian Li ◽  
Xin Hu ◽  
Li Wang ◽  
...  
Keyword(s):  
Retinal Ganglion Cells ◽  
Ganglion Cells ◽  
Neuroprotective Effect ◽  
Somatostatin Receptor ◽  
Retinal Ganglion ◽  
Experimental Glaucoma

scholarly journals Differential Effects of Unfolded Protein Response Pathways on Axon Injury-Induced Death of Retinal Ganglion Cells

Neuron ◽  
2012 ◽  
Vol 73 (3) ◽  
pp. 445-452 ◽  
Author(s):  
Yang Hu ◽  
Kevin K. Park ◽  
Liu Yang ◽  
Xin Wei ◽  
Qiang Yang ◽  
...  
Keyword(s):  
Unfolded Protein Response ◽  
Retinal Ganglion Cells ◽  
Ganglion Cells ◽  
Retinal Ganglion ◽  
Axon Injury ◽  
Differential Effects ◽  
Unfolded Protein ◽  
Protein Response

scholarly journals Losartan Treatment Protects Retinal Ganglion Cells and Alters Scleral Remodeling in Experimental Glaucoma

PLoS ONE ◽  
2015 ◽  
Vol 10 (10) ◽  
pp. e0141137 ◽  
Author(s):  
Harry A. Quigley ◽  
Ian F. Pitha ◽  
Derek S. Welsbie ◽  
Cathy Nguyen ◽  
Matthew R. Steinhart ◽  
...  
Keyword(s):  
Retinal Ganglion Cells ◽  
Ganglion Cells ◽  
Retinal Ganglion ◽  
Experimental Glaucoma ◽  
Losartan Treatment

scholarly journals Overexpression of BMP4 protects retinal ganglion cells in a mouse model of experimental glaucoma

2021 ◽  
pp. 108728
Author(s):  
Dongmei Liu ◽  
Qinqin Deng ◽  
Xinlan Lei ◽  
Wei Lu ◽  
Qingqing Zhao ◽  
...  
Keyword(s):  
Mouse Model ◽  
Retinal Ganglion Cells ◽  
Ganglion Cells ◽  
Retinal Ganglion ◽  
Experimental Glaucoma

FTY720 Protects Retinal Ganglion Cells in Experimental Glaucoma

2014 ◽  
Vol 55 (5) ◽  
pp. 3060 ◽  
Author(s):  
Yuyi You ◽  
Vivek K. Gupta ◽  
Jonathan C. Li ◽  
Nadia Al-Adawy ◽  
Alexander Klistorner ◽  
...  
Keyword(s):  
Retinal Ganglion Cells ◽  
Ganglion Cells ◽  
Retinal Ganglion ◽  
Experimental Glaucoma

scholarly journals The mito-QC Reporter for Quantitative Mitophagy Assessment in Primary Retinal Ganglion Cells and Experimental Glaucoma Models

2020 ◽  
Vol 21 (5) ◽  
pp. 1882
Author(s):  
Ines Rosignol ◽  
Beatriz Villarejo-Zori ◽  
Petra Teresak ◽  
Elena Sierra-Filardi ◽  
Xandra Pereiro ◽  
...  
Keyword(s):  
Retinal Ganglion Cells ◽  
Ganglion Cells ◽  
Ex Vivo ◽  
Iron Chelator ◽  
Stress Factors ◽  
Retinal Ganglion ◽  
Nerve Crush ◽  
Experimental Glaucoma

Mitochondrial damage plays a prominent role in glaucoma. The only way cells can degrade whole mitochondria is via autophagy, in a process called mitophagy. Thus, studying mitophagy in the context of glaucoma is essential to understand the disease. Up to date limited tools are available for analyzing mitophagy in vivo. We have taken advantage of the mito-QC reporter, a recently generated mouse model that allows an accurate mitophagy assessment to fill this gap. We used primary RGCs and retinal explants derived from mito-QC mice to quantify mitophagy activation in vitro and ex vivo. We also analyzed mitophagy in retinal ganglion cells (RGCs), in vivo, using different mitophagy inducers, as well as after optic nerve crush (ONC) in mice, a commonly used surgical procedure to model glaucoma. Using mito-QC reporter we quantified mitophagy induced by several known inducers in primary RGCs in vitro, ex vivo and in vivo. We also found that RGCs were rescued from some glaucoma relevant stress factors by incubation with the iron chelator deferiprone (DFP). Thus, the mito-QC reporter-based model is a valuable tool for accurately analyzing mitophagy in the context of glaucoma.

Programmed cell death of retinal ganglion cells during experimental glaucoma

1995 ◽  
Vol 61 (1) ◽  
pp. 33-44 ◽  
Author(s):  
E. Garcia-Valenzuela ◽  
S. Shareef ◽  
J. Walsh ◽  
S.C. Sharma
Keyword(s):  
Cell Death ◽  
Programmed Cell Death ◽  
Retinal Ganglion Cells ◽  
Ganglion Cells ◽  
Retinal Ganglion ◽  
Experimental Glaucoma
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