scholarly journals Skeletal Muscle Changes in Chronic Cardiac Disease and Failure

2015 ◽  
pp. 1947-1969 ◽  
Author(s):  
Peter J. Kennel ◽  
Donna M. Mancini ◽  
P. Christian Schulze
Keyword(s):  
Skeletal Muscle ◽  
Cardiac Disease ◽  
Muscle Changes

scholarly journals A Time-Course Comparison of Skeletal Muscle Metabolomic Alterations in Walker-256 Tumour-Bearing Rats at Different Stages of Life

Metabolites ◽  
2021 ◽  
Vol 11 (6) ◽  
pp. 404
Author(s):  
Gabriela de Matuoka e Chiocchetti ◽  
Leisa Lopes-Aguiar ◽  
Natália Angelo da Silva Miyaguti ◽  
Lais Rosa Viana ◽  
Carla de Moraes Salgado ◽  
...  
Keyword(s):  
Skeletal Muscle ◽  
Time Course ◽  
Cancer Cachexia ◽  
Tumour Bearing ◽  
Walker 256 Tumour ◽  
Walker 256 ◽  
Muscle Changes ◽  
The Right ◽  
Biomarker Research ◽  
Host Metabolism

Cancer cachexia is a severe wasting condition that needs further study to find ways to minimise the effects of damage and poor prognosis. Skeletal muscle is the most impacted tissue in cancer cachexia; thus, elucidation of its metabolic alterations could provide a direct clue for biomarker research and be applied to detect this syndrome earlier. In addition, concerning the significant changes in the host metabolism across life, this study aimed to compare the metabolic muscle changes in cachectic tumour-bearing hosts at different ages. We performed 1H-NMR metabolomics in the gastrocnemius muscle in weanling and young adult Walker-256 tumour-bearing rats at different stages of tumour evolution (initial, intermediate, and advanced). Among the 49 metabolites identified, 24 were significantly affected throughout tumour evolution and 21 were significantly affected regarding animal age. The altered metabolites were mainly related to increased amino acid levels and changed energetic metabolism in the skeletal muscle, suggesting an expressive catabolic process and diverted energy production, especially in advanced tumour stages in both groups. Moreover, these changes were more severe in weanling hosts throughout tumour evolution, suggesting the distinct impact of cancer cachexia regarding the host’s age, highlighting the need to adopting the right animal age when studying cancer cachexia.

Low-symptomatic skeletal muscle disease in patients with a cardiac disease – Diagnostic approach in skeletal muscle laminopathies

2018 ◽  
Vol 52 (2) ◽  
pp. 174-180 ◽  
Author(s):  
Agnieszka Madej-Pilarczyk ◽  
Michał Marchel ◽  
Karolina Ochman ◽  
Joanna Cegielska ◽  
Roman Steckiewicz
Keyword(s):  
Skeletal Muscle ◽  
Cardiac Disease ◽  
Muscle Disease ◽  
Diagnostic Approach

scholarly journals Age-related changes in skeletal muscle: changes to life-style as a therapy

2018 ◽  
Vol 19 (6) ◽  
pp. 519-536 ◽  
Author(s):  
Rachel McCormick ◽  
Aphrodite Vasilaki
Keyword(s):  
Skeletal Muscle ◽  
Life Style ◽  
Age Related ◽  
Muscle Changes ◽  
Age Related Changes

Skeletal muscle changes due to cerebral palsy

2014 ◽  
pp. 135-155
Author(s):  
Richard L. Lieber ◽  
Lucas R. Smith
Keyword(s):  
Skeletal Muscle ◽  
Cerebral Palsy ◽  
Muscle Changes

Skeletal Muscle Changes in Hypothyroidism

2009 ◽  
pp. 1087-1101 ◽  
Author(s):  
Carlos B. Mantilla ◽  
Douglas E. Dow ◽  
Gary C. Sieck
Keyword(s):  
Skeletal Muscle ◽  
Muscle Changes

scholarly journals The use of ivabradine in a patient with inappropriate sinus tachycardia and cardiomyopathy due to limb girdle muscular dystrophy type 2I

2020 ◽  
Vol 13 (1) ◽  
pp. e230647
Author(s):  
Rajkumar Rajendram ◽  
Fahad AlDhahri ◽  
Naveed Mahmood ◽  
Mubashar Kharal
Keyword(s):  
Skeletal Muscle ◽  
Muscular Dystrophy ◽  
Cardiac Disease ◽  
Sinus Tachycardia ◽  
Prognostic Significance ◽  
Mechanisms Of Action ◽  
Limb Girdle Muscular Dystrophy ◽  
Muscular Dystrophies ◽  
Appropriate Use ◽  
Inappropriate Sinus Tachycardia

Muscular dystrophies are a heterogeneous group of disorders that commonly involve cardiac and skeletal muscle. Comprehensive guidelines for the management of cardiac failure and arrhythmias are available. However, the studies from which their recommendations are derived did not include any patients with muscular dystrophy. Some medications (eg, betablockers) may have significant side effects in this cohort. In some situations the use of agents with unique mechanisms of action such as ivabradine (a ‘funny’ channel inhibitor) may be more appropriate. Use of ivabradine has not previously been reported in limb girdle muscular dystrophy (LGMD). We describe the course of a patient with LGMD type 2I, cardiomyopathy and inappropriate sinus tachycardia treated with ivabradine. As advances in respiratory support have improved the outcomes of patients with muscular dystrophy; the prognostic significance of cardiac disease has increased. Ivabradine is tolerated and may reduce symptoms, morbidity and mortality in this cohort.

Experimental myotonia in mammalian skeletal muscle: changes in membrane properties

1972 ◽  
Vol 331 (4) ◽  
pp. 324-334 ◽  
Author(s):  
R. R�del ◽  
J. Senges
Keyword(s):  
Skeletal Muscle ◽  
Membrane Properties ◽  
Mammalian Skeletal Muscle ◽  
Muscle Changes

Skeletal Muscle Changes with Training in Patients with Coronary Artery Disease

1990 ◽  
Vol 10 (8) ◽  
pp. 271-278 ◽  
Author(s):  
Sonia H. Torres ◽  
Deyanira Almeida ◽  
Jacobo Rosenthal ◽  
Yajaira Lozada-Femández ◽  
Noelina Hernández
Keyword(s):  
Skeletal Muscle ◽  
Coronary Artery Disease ◽  
Coronary Artery ◽  
Artery Disease ◽  
Muscle Changes

scholarly journals Sarcopenia: Age-Related Skeletal Muscle Changes from Determinants to Physical Disability

2006 ◽  
Vol 19 (4) ◽  
pp. 703-719 ◽  
Author(s):  
A. Di Iorio ◽  
M. Abate ◽  
D. Di Renzo ◽  
A. Russolillo ◽  
C. Battaglini ◽  
...  
Keyword(s):  
Skeletal Muscle ◽  
Physical Disability ◽  
Age Related ◽  
Muscle Changes

Temporal pattern of skeletal muscle changes in lambs fed cimaterol

1991 ◽  
Vol 8 (4) ◽  
pp. 549-554 ◽  
Author(s):  
R.M. O'Connor ◽  
W.R. Butler ◽  
D.E. Hogue ◽  
D.H. Beermann
Keyword(s):  
Skeletal Muscle ◽  
Temporal Pattern ◽  
Muscle Changes
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