scholarly journals Age-related changes in skeletal muscle: changes to life-style as a therapy

2018 ◽  
Vol 19 (6) ◽  
pp. 519-536 ◽  
Author(s):  
Rachel McCormick ◽  
Aphrodite Vasilaki
Keyword(s):  
Skeletal Muscle ◽  
Life Style ◽  
Age Related ◽  
Muscle Changes ◽  
Age Related Changes

scholarly journals The relationships between sarcopenic skeletal muscle loss during ageing and macronutrient metabolism, obesity and onset of diabetes

2019 ◽  
Vol 79 (1) ◽  
pp. 158-169 ◽  
Author(s):  
Ailsa A. Welch ◽  
Richard P. G. Hayhoe ◽  
Donnie Cameron
Keyword(s):  
Type 2 Diabetes ◽  
Skeletal Muscle ◽  
Energy Expenditure ◽  
Morphological Changes ◽  
Muscle Loss ◽  
Dietary Recommendations ◽  
Age Related ◽  
Muscle Changes ◽  
Age Related Changes

Skeletal muscle is integral to the metabolism and utilisation of macronutrients; however, substantial muscle loss and morphological changes occur with ageing. These are associated with loss of muscle function and accelerate rapidly from the age of 60 years, leading to the conditions of sarcopenia and frailty. As the relationship between muscle ageing and macronutrient metabolism and utilisation has seen limited research to date, this review focuses on the interactions between skeletal muscle changes during ageing, metabolism and utilisation of fat, carbohydrates and overall energy expenditure.Skeletal muscle contributes less to resting energy expenditure during ageing, potentially contributing to onset of obesity from middle age. Age-related changes to skeletal muscle lead to glucose dysregulation, with consequent reduction in glycaemic control, increased insulin resistance and ultimately onset of type-2 diabetes. Recent studies indicate that high total fat and SFA intake are detrimental to skeletal muscle, while higher intakes of PUFA are protective. Age-associated changes in skeletal muscle may also reduce total fatty acid utilisation.In conclusion, further research is needed to understand the relationships between macronutrient metabolism and utilisation and age-related changes to skeletal muscle. No dietary recommendations exist specifically for skeletal muscle health during ageing, but we advise individuals to follow healthy eating guidelines, by consuming sufficient protein, fruit and vegetables, and limited SFA and to maintain physically active lifestyles. Clinicians responsible for managing type-2 diabetes need to be aware of growing evidence relating age-related skeletal muscle changes to diabetes onset and progression.

Understanding Age-Related Changes in Skeletal Muscle Metabolism: Differences Between Females and Males

2016 ◽  
Vol 36 (1) ◽  
pp. 129-156 ◽  
Author(s):  
Brandon J.F. Gheller ◽  
Emily S. Riddle ◽  
Melinda R. Lem ◽  
Anna E. Thalacker-Mercer
Keyword(s):  
Skeletal Muscle ◽  
Muscle Metabolism ◽  
Skeletal Muscle Metabolism ◽  
Age Related ◽  
Age Related Changes

Age-related changes in glutathione availability and skeletal muscle carbonyl content in healthy rats

2004 ◽  
Vol 39 (2) ◽  
pp. 203-210 ◽  
Author(s):  
Laurent Mosoni ◽  
Denis Breuillé ◽  
Caroline Buffière ◽  
Christiane Obled ◽  
Philippe Patureau Mirand
Keyword(s):  
Skeletal Muscle ◽  
Carbonyl Content ◽  
Age Related ◽  
Age Related Changes

scholarly journals Age-related changes in collagen synthesis and degradation in rat tissues. Importance of degradation of newly synthesized collagen in regulating collagen production

1991 ◽  
Vol 276 (2) ◽  
pp. 307-313 ◽  
Author(s):  
P K Mays ◽  
R J McAnulty ◽  
J S Campa ◽  
G J Laurent
Keyword(s):  
Skeletal Muscle ◽  
Collagen Synthesis ◽  
Rat Tissues ◽  
Age Related ◽  
Developmental Growth ◽  
Cross Links ◽  
Fractional Synthesis ◽  
Synthesis And Degradation ◽  
Age Related Changes

During developmental growth, collagens are believed to be continuously deposited into an extracellular matrix which is increasingly stabilized by the formation of covalent cross-links throughout life. However, the age-related changes in rates of synthetic and degradative processes are less well understood. In the present study we measured rates of collagen synthesis in vivo using a flooding dose of unlabelled proline given with [14C]proline and determining production of hydroxy[14C]proline. Degradation of newly synthesized collagen was estimated from the amount of free hydroxy [14C]proline in tissues 30 min after injection. Collagen fractional synthesis rates ranged from about 5%/day in skeletal muscle to 20%/day in hearts of rats aged 1 month. At 15 months of age, collagen fractional synthesis rates had decreased markedly in lung and skin, but in skeletal muscle and heart, rates were unchanged. At 24 months of age, synthesis rates had decreased by at least 10-fold in all tissues, compared with rates at 1 month. The proportion of newly synthesized collagen degraded ranged from 6.4 +/- 0.4% in skin to 61.6 +/- 5.0% in heart at 1 month of age. During aging the proportion degraded increased in all tissues to maximal values at 15 months, ranging from 56 +/- 7% in skin to 96 +/- 1% in heart. These data suggest that there are marked age-related changes in rates of collagen metabolism. They also indicate that synthesis is active even in old animals, where the bulk of collagens produced are destined to be degraded.

scholarly journals Sarcopenia: Age-Related Skeletal Muscle Changes from Determinants to Physical Disability

2006 ◽  
Vol 19 (4) ◽  
pp. 703-719 ◽  
Author(s):  
A. Di Iorio ◽  
M. Abate ◽  
D. Di Renzo ◽  
A. Russolillo ◽  
C. Battaglini ◽  
...  
Keyword(s):  
Skeletal Muscle ◽  
Physical Disability ◽  
Age Related ◽  
Muscle Changes

Expression of igf-i and gh-receptor (ghr) mrna in liver and skeletal muscle of different pig breeds

1995 ◽  
Vol 1995 ◽  
pp. 183-183
Author(s):  
J.M. Brameld ◽  
J.L. Atkinson ◽  
T.J. Budd ◽  
J.C. Saunders ◽  
A.M. Salter ◽  
...  
Keyword(s):  
Skeletal Muscle ◽  
Energy Availability ◽  
Pig Breeds ◽  
Gh Receptor ◽  
Age Related ◽  
Igf I ◽  
Class 1 ◽  
Cellular Domain ◽  
Promoter Usage ◽  
Age Related Changes

Previous studies of the porcine GH-IGF axis have demonstrated age related changes in liver, but not LD muscle, in expression of both GH-receptor (GHR) and IGF-I genes (Brameld et al, 1993; 1995), and also effects of energy availability on the expression of IGF-I in liver, but not in LD muscle (Weller et al, 1994). The work described here was carried out to study the expression of IGF-I and GHR mRNA in liver and skeletal muscle from different breeds of pig. The probes used were as described previously (Brameld et al, 1993; 1995; Weller et al, 1993; 1994), and were designed to monitor promoter usage for IGF-I expression, with the two promoters giving rise to class 1 and 2 transcripts, and also expression of the extra-cellular domain of the GH-receptor.

scholarly journals Bone and Muscle Crosstalk in Aging

2020 ◽  
Vol 8 ◽  
Author(s):  
Chen He ◽  
Wenzhen He ◽  
Jing Hou ◽  
Kaixuan Chen ◽  
Mei Huang ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Bone Mineral Density ◽  
Skeletal Muscle ◽  
Bone Cells ◽  
The Elderly ◽  
Extracellular Vesicle ◽  
Mineral Density ◽  
Age Related ◽  
Age Related Changes

Osteoporosis and sarcopenia are two age-related diseases that affect the quality of life in the elderly. Initially, they were thought to be two independent diseases; however, recently, increasing basic and clinical data suggest that skeletal muscle and bone are both spatially and metabolically connected. The term “osteosarcopenia” is used to define a condition of synergy of low bone mineral density with muscle atrophy and hypofunction. Bone and muscle cells secrete several factors, such as cytokines, myokines, and osteokines, into the circulation to influence the biological and pathological activities in local and distant organs and cells. Recent studies reveal that extracellular vesicles containing microRNAs derived from senescent skeletal muscle and bone cells can also be transported and aid in regulating bone-muscle crosstalk. In this review, we summarize the age-related changes in the secretome and extracellular vesicle-microRNAs secreted by the muscle and bone, and discuss their interactions between muscle and bone cells during aging.

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