scholarly journals Chronic Inhibition of CYP3A is Temporarily Reduced by Each Hemodialysis Session in Patients With End‐Stage Renal Disease

2020 ◽  
Vol 108 (4) ◽  
pp. 866-873
Author(s):  
Erlend Johannessen Egeland ◽  
Bartlomiej J. Witczak ◽  
Hasse Khiabani Zaré ◽  
Hege Christensen ◽  
Anders Åsberg ◽  
...  
PLoS ONE ◽  
2021 ◽  
Vol 16 (7) ◽  
pp. e0240570
Author(s):  
Cristiane Rickli ◽  
Lais Daiene Cosmoski ◽  
Fábio André dos Santos ◽  
Gustavo Henrique Frigieri ◽  
Nicollas Nunes Rabelo ◽  
...  

End-stage renal disease (ESRD) is treated mainly by hemodialysis, however, hemodialysis is associated with frequent complications, some of them involve the increased intracranial pressure. In this context, monitoring the intracranial pressure of these patients may lead to a better understanding of how intracranial pressure morphology varies with hemodialysis. This study aimed to follow-up patients with ESRD by monitoring intracranial pressure before and after hemodialysis sessions using a noninvasive method. We followed-up 42 patients with ESRD in hemodialysis, for six months. Noninvasive intracranial pressure monitoring data were obtained through analysis of intracranial pressure waveform morphology, this information was uploaded to Brain4care® cloud algorithm for analysis. The cloud automatically sends a report containing intracranial pressure parameters. In total, 4881 data points were collected during the six months of follow-up. The intracranial pressure parameters (time to peak and P2/P1 ratio) were significantly higher in predialysis when compared to postdialysis for the three weekly sessions and throughout the follow-up period (p<0.01) data showed general improvement in brain compliance after the hemodialysis session. Furthermore, intracranial pressure parameters were significantly higher in the first weekly hemodialysis session (p<0.05). In conclusion, there were significant differences between pre and postdialysis intracranial pressure in patients with ESRD on hemodialysis. Additionally, the pattern of the intracranial pressure alterations was consistent over time suggesting that hemodialysis can improve time to peak and P2/P1 ratio which may reflect in brain compliance.


2020 ◽  
Author(s):  
Cristiane Rickli ◽  
Lais Daiene Cosmoski ◽  
Fábio André dos Santos ◽  
Gustavo Henrique Frigieri ◽  
Nicollas Nunes Rabelo ◽  
...  

AbstractEnd-stage renal disease (ESRD) is treated mainly by hemodialysis, however, hemodialysis is associated with frequent complications, some of them involve the increased intracranial pressure. In this context, monitoring the intracranial pressure of these patients may lead to a better understanding of how intracranial pressure morphology varies with hemodialysis. This study aimed to follow-up patients with ESRD by monitoring intracranial pressure before and after hemodialysis sessions using a noninvasive method. We followed-up 42 patients with ESRD in hemodialysis, for six months. Noninvasive intracranial pressure monitoring data were obtained through analysis of intracranial pressure waveform morphology, this information was uploaded to Brain4care® cloud algorithm for analysis. The cloud automatically sends a report containing intracranial pressure parameters. In total, 4881 data points were collected during the six months of follow-up. The intracranial pressure parameters (time to peak and P2/P1 ratio) were significantly higher in predialysis when compared to postdialysis for the three weekly sessions and throughout the follow-up period (p<0.01) data showed general improvement in brain compliance after the hemodialysis session. Furthermore, intracranial pressure parameters were significantly higher in the first weekly hemodialysis session (p<0.05). In conclusion, there were significant differences between pre and postdialysis intracranial pressure in patients with ESRD on hemodialysis. Additionally, the pattern of the intracranial pressure alterations was consistent over time suggesting that hemodialysis can improve time to peak and P2/P1 ratio which may reflect in brain compliance.


2015 ◽  
Vol 19 (4) ◽  
pp. 553-561 ◽  
Author(s):  
Justine Magnard ◽  
Julien Lardy ◽  
Angelo Testa ◽  
Dan Hristea ◽  
Thibault Deschamps

2021 ◽  
pp. 12-15
Author(s):  
A. O. Nykonenko ◽  
S. R. Vildanov

Introduction. Nowadays hemodialysis is the most widespread way of treatment concerning the end-stage renal disease. The variant of choice as for permanent vascular access for hemodialysis is arteriovenous fistula. An actual problem is the deterioration of the patency of arteriovenous fistula. According to the research, most patients do not know about the risks associated with intradialytic hypotension. Under these conditions, research with determining the level of critical intradialytic hypotension is particularly relevant. Purpose of the work is to study and evaluate intradialytic hypotension as a risk factor for thrombosis of arteriovenous fistulas. Materials and methods. 60 patients were examined with end-stage renal disease, receiving of hemodialysis. Among these patients a thrombosis of arteriovenous fistula appeared in the long term (7.5 (3.0–17.6) months) after the surgery. The average age of patients was (54.1 ± 11.8) years; there were 30 (50%) men, 30 (50%) women. Results. According to the results of our study, 38 (63 %) patients had hypotension at the end of the hemodialysis session. Conclusions. Blood hypotension is one of the main predictors of thrombosis of arteriovenous fistula in the late postoperative period. A decrease in systolic blood pressure on 35.0 (25.0–50.0) mm Hg to 100.0 (90.0–110.0) mm Hg is critical for the patency of arteriovenous fistula. Adequate control and correction of blood pressure (in particular, during a hemodialysis session) can prevent thrombosis of arteriovenous fistula.


1979 ◽  
Vol 45 (1) ◽  
pp. 231-239 ◽  
Author(s):  
Wiley C. Rasbury ◽  
Robert S. Fennell ◽  
Brenda G. Eastman ◽  
Eduardo H. Garin ◽  
George Richards

Children ( N = 14) with End Stage Renal Disease were compared pre- and post-hemodialysis session on measures of attention, problem solving and learning with 14 control subjects. In contrast to the findings for adult patients no significant differences were found between the End Stage Renal Disease and control subjects on any of the cognitive tasks employed nor were there any significant differences pre- to post-dialysis session for the group. The results were discussed in terms of the general efficiency of the hemodialysis regimen employed and other factors which might affect performance of these ill children.


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