scholarly journals Serotonin‐affecting antidepressant use in relation to platelet reactivity

2021 ◽  
Author(s):  
Joseph Grech ◽  
Melissa Victoria Chan ◽  
Chinedu Ochin ◽  
Amber Lachapelle ◽  
Florian Thibord ◽  
...  
Keyword(s):  
Platelet Reactivity ◽  
Antidepressant Use

Patient's decision making regarding antidepressant use

2008 ◽  
Author(s):  
A. Dijkstra ◽  
M. Jaspers ◽  
M. van Zwieten
Keyword(s):  
Decision Making ◽  
Antidepressant Use

Stopping Antidepressant Use While Pregnant May Pose Risks

2006 ◽  
Author(s):  
Keyword(s):  
Antidepressant Use

Recent Declining Suicide Rates Not Tied to Antidepressant Use

2005 ◽  
Vol 33 (6) ◽  
pp. 22
Author(s):  
BRUCE JANCIN
Keyword(s):  
Suicide Rates ◽  
Antidepressant Use

Antidepressant Use Dropped 10% in Youth

2005 ◽  
Vol 35 (6) ◽  
pp. 47
Author(s):  
CHRISTINE KILGORE
Keyword(s):  
Antidepressant Use

Study Finds Lower Suicide Rates Not Due to Antidepressant Use

2005 ◽  
Vol 35 (16) ◽  
pp. 33
Author(s):  
BRUCE JANCIN
Keyword(s):  
Suicide Rates ◽  
Antidepressant Use

A Physiologic Regulator of Collagen-Induced Platelet Aggregation: Inhibition by Clq

1981 ◽  
Vol 45 (02) ◽  
pp. 110-115 ◽  
Author(s):  
György Csákó ◽  
Eva A Suba
Keyword(s):  
Platelet Aggregation ◽  
Human Platelet ◽  
Platelet Reactivity ◽  
High Specificity ◽  
Turbidimetric Method ◽  
Specific Manner ◽  
Aggregation Inhibition ◽  
Different Tissues

SummaryPlatelet aggregations were studied by a turbidimetric method in citrated human platelet-rich plasmas (PRP) in vitro. Human Clq inhibited the aggregations caused by collagens derived from different tissues and species. Clq was needed by weight in comparable quantities to collagen for neutralizing the aggregating effect. The dependence of the inhibitory reaction on the preincubation of platelets with Clq and the differences in the occurrence of aggregating substances in supernatants of PRP triggered with collagen in the presence or absence of Clq, confirmed that Clq exerts its effect by preventing fixation of collagen to platelets. In addition, the high specificity of the inhibitory action of Clq for collagen-induced platelet aggregation was demonstrated by results obtained for testing a variety of aggregating agents in combination with Clq and/or collagen.Since normal concentrations of Clq in the blood are in the range of inhibitory doses of Clq for collagen-induced platelet aggregations in vitro and upon activation of complement Clq is known to dissociate from Cl, it is proposed that Clq may participate in a highly specific manner in regulating platelet reactivity to collagen in vivo.

Platelet Adhesion to Subendothelium - Effect of Shear Rate, Hematocrit and Platelet Count on the Dynamic Equilibrium Between Platelets Adhering to and Detaching from the Surface

1985 ◽  
Vol 54 (04) ◽  
pp. 857-861 ◽  
Author(s):  
Andrea Remuzzi ◽  
Lucia Raffaella Languino ◽  
Vincenzo Costantini ◽  
Vincenzo Guardabasso ◽  
Giovanni de Gartano ◽  
...  
Keyword(s):  
Platelet Adhesion ◽  
Initial Rate ◽  
Dynamic Equilibrium ◽  
Dynamic Condition ◽  
Platelet Reactivity ◽  
Experimental Conditions ◽  
Platelet Suspension ◽  
Shear Rates ◽  
Platelet Concentration ◽  
Adhesion Rate

SummaryThe adherence of human 3H-adenine-labeled platelets to rat subendothelium was quantitated using a rotating probe device. Platelet adhesion increased in relation to the rotation time, reaching a plateau value in about 4-6 min without any further increase. A non-linear fitting analysis of experimental data allowed calculations of initial rate and plateau value of platelet adhesion. Increasing the shear rates (from 35 to 150 sec-1) or the hematocrit (from 10% to 40%), both the adhesion rate and the plateau value were increased. When different platelet concentrations were used the adhesion rate and the plateau calculated increased with platelet concentration. Different plateau values were obtained in the experimental conditions considered. This suggests that the plateau was not reached for the complete occupation of the subendothelial surface by the adherent platelets. Experiments using two different vessels rotated in the same platelet suspension or, viceversa, the same vessel rotated successively in two fresh platelet suspensions, showed that the plateau was not determined by reduced platelet reactivity. Rotating the same vessel first in radiolabeled platelets, until the plateau was reached, and secondly in non labeled platelets, or viceversa, showed that the plateau was indeed a dynamic condition where the number of platelets adhering and detaching reached equilibrium. These observations suggest that the platelet adhesion to subendothelium is the final equilibrium of two platelet fluxes, one adhering to the surface and another detaching from the surface.

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