scholarly journals EPR Characterisation of Phthalocyanine Radical Anions in Near‐Infrared Photocleavage of the Hydrophilic Axial Ligand of a Photoimmunotherapeutic Reagent, IR700

ChemPhotoChem ◽  
2021 ◽  
Author(s):  
Osamu Inanami ◽  
Wakako Hiraoka ◽  
Yuto Goto ◽  
Hideo Takakura ◽  
Mikako Ogawa
Keyword(s):  
Near Infrared ◽  
Axial Ligand ◽  
Radical Anions

scholarly journals Axial-Ligand-Cleavable Silicon Phthalocyanines Triggered by Near-Infrared Light toward Design of Photosensitizers for Photoimmunotherapy

2021 ◽  
Author(s):  
Hideo Takakura ◽  
Shino Matsuhiro ◽  
Masato Kobayashi ◽  
Yuto Goto ◽  
Mei Harada ◽  
...  
Keyword(s):  
Near Infrared ◽  
Axial Ligand ◽  
Alkoxy Group ◽  
Infrared Light ◽  
Photochemical Process ◽  
Protonation Reaction ◽  
Axial Ligands ◽  
Nir Light ◽  
Cleavage Efficiency ◽  
Silicon Phthalocyanines

Abstract Near-infrared photoimmunotherapy (NIR-PIT) is a novel phototherapy for the treatment of cancer that uses NIR light and conjugates of antibody-IR700, a silicon phthalocyanine photosensitizer. A key feature of NIR-PIT is light-induced axial ligand cleavage of IR700, which finally causes cytotoxicity. Here, we focused on protonation of the axial ligand on the IR700 anion radical during the photochemical process. The Gibbs energy in the protonation reaction of IR700 derivatives with different axial ligands was calculated. These calculations suggested the order of the cleavage efficiency corresponds to the basicity of the axial ligand (i.e. alkoxy > siloxy (IR700) > phenoxy ≈ oxycarbonyl), which was confirmed by the photoirradiation experiments with synthesized compounds. Thus, axial ligand cleavage is significantly dependent on the basicity of the axial ligand. Our findings suggest that PIT reagent with an IR700 derivative bearing alkoxy group would show better efficacy than IR700.

Regulating morphologies and near-infrared photothermal conversion of perylene bisimide via sequence-dependent peptide self-assembly

2018 ◽  
Vol 54 (18) ◽  
pp. 2208-2211 ◽  
Author(s):  
Lingyun Cui ◽  
Yang Jiao ◽  
Anhe Wang ◽  
Luyang Zhao ◽  
Qianqian Dong ◽  
...  
Keyword(s):  
Conversion Efficiency ◽  
Self Assembly ◽  
Near Infrared ◽  
Aqueous Media ◽  
Radical Anions ◽  
Photothermal Conversion ◽  
Perylene Bisimide ◽  
Sequence Dependent

The behavior of PBI self-assembly can be precisely organised by the conjugation of sequence dependent dipeptides in aqueous media resulting in different assembled nanostructures with improved radical anions yield and enhanced photothermal conversion efficiency.

scholarly journals Near-infrared absorbing organic materials

2004 ◽  
Vol 76 (7-8) ◽  
pp. 1435-1443 ◽  
Author(s):  
Z. Y. Wang ◽  
J. Zhang ◽  
X. Wu ◽  
Maria Birau ◽  
Guomin Yu ◽  
...  
Keyword(s):  
Metal Complexes ◽  
Near Infrared ◽  
Organic Materials ◽  
Mixed Valence ◽  
Radical Anions ◽  
Absorbing Materials ◽  
Dinuclear Metal Complexes ◽  
Sandwich Type ◽  
Optical Attenuators ◽  
Variable Optical Attenuators

Organic solids and polymers that absorb in the near-infrared (NIR) region (1000–2000 nm) represent a class of emerging materials and show a great potential for use in photonics and telecommunications. The radical anions of stacked aromatic imides, fused phorphyrin arrays, polythiophenes, sandwich-type lanthanide bisphthalocyanines, semiquinones, and mixed-valence dinuclear metal complexes are a few known examples of NIR-absorbing organic materials. Most of these NIR-absorbing materials are also electro- chemically active or electrochromic (EC). This brief review covers several types of NIR-absorbing organic materials and discusses their potential for applications in EC variable optical attenuators (VOAs).

EPR Characterisation of Phthalocyanine Radical Anions in NIR Photocleavage of the Hydrophilic Axial Ligand of a Photoimmunotherapeutic Reagent, IR700

ChemPhotoChem ◽  
2021 ◽  
Author(s):  
Osamu Inanami ◽  
Wakako Hiraoka ◽  
Yuto Goto ◽  
Hideo Takakura ◽  
Mikako Ogawa
Keyword(s):  
Axial Ligand ◽  
Radical Anions

scholarly journals Photoinduced electron transfer from rylenediimide radical anions and dianions to Re(bpy)(CO)3 using red and near-infrared light

2017 ◽  
Vol 8 (5) ◽  
pp. 3821-3831 ◽  
Author(s):  
Nathan T. La Porte ◽  
Jose F. Martinez ◽  
Svante Hedström ◽  
Benjamin Rudshteyn ◽  
Brian T. Phelan ◽  
...  
Keyword(s):  
Electron Transfer ◽  
Photoinduced Electron Transfer ◽  
Near Infrared ◽  
Metal Center ◽  
Infrared Light ◽  
Radical Anions ◽  
Near Infrared Light

Photoinduced electron transfer dynamics are described for a set of dyads comprising rylenediimide anion chromophores and a Re(bpy)(CO)3 metal center.

Construction of a near-infrared responsive upconversion nanoplatform against hypoxic tumors via NO-enhanced photodynamic therapy

Nanoscale ◽  
2020 ◽  
Vol 12 (14) ◽  
pp. 7875-7887 ◽  
Author(s):  
Ying Lan ◽  
Xiaohui Zhu ◽  
Ming Tang ◽  
Yihan Wu ◽  
Jing Zhang ◽  
...  
Keyword(s):  
Photodynamic Therapy ◽  
Near Infrared ◽  
Upconversion Nanoparticles

A near-infrared (NIR) activated theranostic nanoplatform based on upconversion nanoparticles (UCNPs) is developed in order to overcome the hypoxia-associated resistance in photodynamic therapy by photo-release of NO upon NIR illumination.

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