Pleomorphic adenoma with bizarre myoepithelial cells: A diagnostic challenge on cytologic smear

2019 ◽  
Vol 47 (12) ◽  
pp. 1283-1286
Author(s):  
Mana Taweevisit ◽  
Paul S. Thorner
Keyword(s):  
Pleomorphic Adenoma ◽  
Myoepithelial Cells ◽  
Diagnostic Challenge ◽  
Cytologic Smear

Two sides of the same coin: Insights into the myoepithelial cells in carcinoma ex pleomorphic adenoma development

2021 ◽  
Vol 157 ◽  
pp. 103195
Author(s):  
João Figueira Scarini ◽  
Erika Said Abu Egal ◽  
Reydson Alcides de Lima-Souza ◽  
Lívia Ramalho Crescencio ◽  
Carolina Emerick ◽  
...  
Keyword(s):  
Pleomorphic Adenoma ◽  
Myoepithelial Cells ◽  
Carcinoma Ex Pleomorphic Adenoma ◽  
Two Sides

Spindle cell lipoma mimicking pleomorphic adenoma: A diagnostic challenge on cytology

2018 ◽  
Vol 47 (4) ◽  
pp. 341-344
Author(s):  
Manveen Kaur ◽  
Debajyoti Chatterjee ◽  
Reetu Kundu ◽  
Rajpal S. Punia ◽  
Vaibhav Saini
Keyword(s):  
Pleomorphic Adenoma ◽  
Spindle Cell ◽  
Spindle Cell Lipoma ◽  
Diagnostic Challenge

scholarly journals Pleomorphic adenoma of the upper lip: a case report and review of literature

2016 ◽  
Vol 4 (1) ◽  
pp. 8
Author(s):  
Rashmi Metgud ◽  
Bhardwaj Tina Neelesh ◽  
Saurabh Goel ◽  
Smitha Nail ◽  
Shrikant Patel ◽  
...  
Keyword(s):  
Salivary Gland ◽  
Pleomorphic Adenoma ◽  
Unusual Case ◽  
Needle Aspiration ◽  
Myoepithelial Cells ◽  
Upper Lip ◽  
Epithelial Tumor ◽  
Needle Aspiration Cytology ◽  
Benign Mixed Tumor ◽  
Morphological Patterns

<p>Pleomorphic Adenoma is a benign epithelial tumor arising from the salivary gland. It is a benign mixed tumor composed of epithelial and myoepithelial cells arranged with various morphological patterns, demarcated from surrounding tissues by fibrous capsule. In this article, we report an unusual case of 30 year, male with a single, nodular swelling evident in the upper lip which was discovered during a routine dental procedure. Fine Needle Aspiration Cytology (FNAC) was planned for the patient, where a of cytological diagnosis of Pleomorphic Adenoma was rendered, which was confirmed by biopsy. Hence, this highlights, FNAC makes up an important diagnosing tool as the first line of investigation to distinguish between benign and malignant salivary gland neoplasms.</p>

scholarly journals Malignant Myoepithelial Carcinoma Expleomorphic Adenoma of the Hard Palate: An Aggressive Tumor with Diagnostic Dilemma

2014 ◽  
Vol 5 (2) ◽  
pp. 72-77
Author(s):  
Sudhir Naik ◽  
Rajshekar Halkud ◽  
KT Siddappa ◽  
Akshay Shivappa ◽  
Siddharth Biswas ◽  
...  
Keyword(s):  
Pleomorphic Adenoma ◽  
Hard Palate ◽  
De Novo ◽  
Metastatic Tumor ◽  
Myoepithelial Cells ◽  
Concurrent Chemotherapy ◽  
Adjuvant Chemoradiotherapy ◽  
Myoepithelial Carcinoma ◽  
Diagnostic Dilemma ◽  
Aggressive Tumor

ABSTRACT Background/Objectives Myoepithelial carcinomas are uncommon neoplasms that account for about 10% of all myoepitheliomas. The invasiveness varies from a locally aggressive to highly metastatic tumor which may arise de novo or in a pleomorphic adenoma. Myoepitheliomas arise from myoepithelial cells lacking ductal differentiation which exhibit both epithelial and smooth muscle cell elements. Case report We report a case of palatal swelling excised 4 years back, as pleomorphic adenoma, which later recurred as malignant myoepithelial carcinoma expleomorphic adenoma of the palate. CECT of the paranasal air sinuses did not show any bony invasion of the hard palate. So he was given radical radiotherapy with concurrent chemotherapy but after 3 years developed recurnce and metastasis to the skin and the lungs. The patient was referred to oral chemotherapy on a palliative basis. Conclusion Malignant myoepithelial carcinoma expleomorphic adenoma of the hard palate is a highly aggressive rare tumor of the hard palate. Radical management with surgery and adjuvant chemoradiotherapy improves survival in these patients. Followup with metastatic workup should be accurate as the tumor is highly aggressive with poor prognosis. How to cite this article Shenoy AM, Halkud R, Shivappa A, Chavan p, Sunil KC, Sarvadyna J, Samskruthi M, Siddappa KT, Biswas S, Naik SM. Malignant Myoepithelial Carcinoma Expleomorphic Adenoma of the Hard palate: An Aggressive Tumor with Diagnostic Dilemma. Int J Head Neck Surg 2014;5(2):72-77.

scholarly journals Pleomorphic Adenoma of the Sublingual Salivary Gland: An Unusual Diagnostic Challenge

2012 ◽  
Vol 21 (3) ◽  
pp. 282-284 ◽  
Author(s):  
Stylianos Dalampiras ◽  
Dimitrios Andreadis ◽  
Apostolos Epivatianos ◽  
Leonidas Sakas ◽  
Peter Stanko
Keyword(s):  
Salivary Gland ◽  
Pleomorphic Adenoma ◽  
Diagnostic Challenge

Parapharyngeal chordoma: A diagnostic challenge and potential mimic of pleomorphic adenoma on fine-needle aspiration cytology

2011 ◽  
Vol 41 (1) ◽  
pp. 85-91 ◽  
Author(s):  
Michael Castro ◽  
Deniz Aslan ◽  
J. Carlos Manivel ◽  
Stefan E. Pambuccian
Keyword(s):  
Pleomorphic Adenoma ◽  
Fine Needle Aspiration ◽  
Fine Needle Aspiration Cytology ◽  
Needle Aspiration ◽  
Diagnostic Challenge ◽  
Aspiration Cytology ◽  
Fine Needle ◽  
Needle Aspiration Cytology

Malignant Plasmacytoid Myoepithelioma of the Palate: Histological Observations Compared to Benign Predominant Plasmacytoid Myoepithelial Cells in Pleomorphic Adenoma of the Palate

1998 ◽  
Vol 22 (2) ◽  
pp. 153-160 ◽  
Author(s):  
Hiroko Kuwabara ◽  
Hirotsugu Uda ◽  
Kazunori Miyabe ◽  
Katsuhiro Saito ◽  
Toshiyuki Shibanushi
Keyword(s):  
Pleomorphic Adenoma ◽  
Myoepithelial Cells

scholarly journals Cystic and florid squamous metaplasia in pleomorphic adenoma of palate – A diagnostic dilemma

2014 ◽  
Vol 5 (4) ◽  
pp. 108-110 ◽  
Author(s):  
H Kaveri ◽  
K Gopalkrishnana ◽  
Anehosur Venkatesh
Keyword(s):  
Pleomorphic Adenoma ◽  
Myoepithelial Cell ◽  
Benign Tumor ◽  
Squamous Metaplasia ◽  
Myoepithelial Cells ◽  
Cystic Degeneration ◽  
Minor Trauma ◽  
Medical Sciences ◽  
Diagnostic Dilemma

Pleomorphic adenoma is a benign tumor of salivary gland. Controversy regarding the origin of various mesenchymal components exists and myoepithelial cell has a key role. Metaplastic process is triggered by minor trauma and probable etiology for this change is ischemia. It is diagnostically challenging, because diagnostic pit falls in the presence of mucinous and squamous metaplasia. Report a case of pleomorphic adenoma in the palate of a 35 years old Indian female. Biopsy revealed epithelial component with extensive squamous metaplasia and cystic degeneration. Here we discuss the role of myoepithelial cells in the pathogenesis of pleomorphic adenoma and diagnostic pit falls. DOI: http://dx.doi.org/10.3126/ajms.v5i4.10434 Asian Journal of Medical Sciences 2014 Vol.5(4); 108-110

scholarly journals Pleomorphic Adenoma of Lacrimal Gland: A Rare Entity

2021 ◽  
Vol 8 (7) ◽  
pp. C100-104
Author(s):  
Kirti Chadha Kazi ◽  
Vivek Choodamani Parameshwar ◽  
Vikas S Kavishwar ◽  
Prithesh Bhaskar Shetty
Keyword(s):  
Pleomorphic Adenoma ◽  
Lacrimal Gland ◽  
Histopathological Examination ◽  
Mass Effect ◽  
Final Diagnosis ◽  
Myoepithelial Cells ◽  
Significant Loss ◽  
Excision Biopsy ◽  
Post Surgery ◽  
Rare Tumours

Among the various tumours affecting the lacrimal gland, pleomorphic adenomas though most common can present clinically and radiologically as worrisome tumours. Histopathologic diagnosis hence is very critical for these tumours. We present a case of pleomorphic adenoma of the lacrimal gland which we encountered at our institutes. The patient was a 46-year-old male who came with complaints of a gradually progressing swelling in the right eye not associated with much pain or significant loss of vision. MRI revealed a large lobulated extrachoanal mass causing mass effect and scalloping of the adjacent bony structures. An excision biopsy was done and sent for histopathological examination. Histologically the tumour showed a biphasic morphology comprising of epithelial (ductal and myoepithelial) and chondromyxoid stromal components. Immunohistochemistry showed positivity for pan CK and CK 7 in ductal epithelial cells, p63 and S100 in myoepithelial cells and a low Ki67 index. On the basis of immunohistochemistry profile along with clinicoradiological correlation a final diagnosis of pleomorphic adenoma of the lacrimal gland was made. The patient post-surgery was doing well but was lost to follow up. It can thus be seen that is it absolutely necessary to accurately diagnose these benign but clinically misconceiving rare tumours of the lacrimal gland for appropriate management of such patients.

scholarly journals Cytological variety of myoepithelial cells in pleomorphic adenoma of salivary gland.

1997 ◽  
Vol 36 (2) ◽  
pp. 128-131 ◽  
Author(s):  
Mitsuyoshi HIROKAWA ◽  
Miyuki KABATA ◽  
Michio SHIMIZU
Keyword(s):  
Salivary Gland ◽  
Pleomorphic Adenoma ◽  
Myoepithelial Cells
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