Application of a non‐target variable data independent workflow (vDIA) for the screening of prohibited substances in doping control testing

2020 ◽  
Author(s):  
David K.K. Leung ◽  
April S.Y. Wong ◽  
Q.L. Zhou ◽  
Terence S.M. Wan ◽  
Emmie N.M. Ho
Keyword(s):  
Doping Control ◽  
Target Variable ◽  
In Doping ◽  
Variable Data

A Review of Analytical Methods for the Determination of Tibolone: Pharmacokinetics and Pharmaceutical Formulations Analysis and Application in Doping Control

2020 ◽  
Vol 17 (1) ◽  
pp. 31-39
Author(s):  
Marilene Lopes Ângelo ◽  
Fernanda de Lima Moreira ◽  
Ana Laura Araújo Santos ◽  
Hérida Regina Nunes Salgado ◽  
Magali Benjamim de Araújo
Keyword(s):  
Mass Spectrometry ◽  
Liquid Chromatography ◽  
Analytical Methods ◽  
Estrogenic Activity ◽  
Biological Fluids ◽  
Pharmaceutical Formulations ◽  
Doping Control ◽  
Specific Effects ◽  
In Doping

Background:: Tibolone is a synthetic steroid commercialized by Organon under the brand name Livial (Org OD14), which is used in hormone therapy for menopause management and treatment of postmenopausal osteoporosis. Tibolone is defined as a selective tissue estrogenic activity regulator (STEAR) demonstrating tissue-specific effects on several organs such as brain, breast, urogenital tract, endometrium, bone and cardiovascular system. Aims:: This work aims to (1) present an overview of important published literature on existing methods for the analysis of tibolone and/or its metabolites in pharmaceutical formulations and biological fluids and (2) to conduct a critical comparison of the analytical methods used in doping control, pharmacokinetics and pharmaceutical formulations analysis of tibolone and its metabolites. Results and conclusions: : The major analytical method described for the analysis of tibolone in pharmaceutical formulations is High Pressure Liquid Chromatography (HPLC) coupled with ultraviolet (UV) detection, while Liquid Chromatography (LC) or Gas Chromatography (GC) used in combination with Mass Spectrometry (MS) or tandem mass spectrometry (MS/MS) is employed for the analysis of tibolone and/or its metabolites in biological fluids.

Qualitative screening in doping control by MALDI-TOF/TOF mass spectrometry: A proof-of-evidence

2012 ◽  
Vol 71 ◽  
pp. 193-197 ◽  
Author(s):  
E. Galano ◽  
M. Fidani ◽  
F. Baia ◽  
L. Palomba ◽  
G. Marino ◽  
...  
Keyword(s):  
Mass Spectrometry ◽  
Doping Control ◽  
Maldi Tof ◽  
In Doping

Application of the new ion trap detector in doping control

1988 ◽  
Vol 6 (6-8) ◽  
pp. 987-993
Author(s):  
E.G. de Jong ◽  
R.A.A. Maes ◽  
J.M. van Rossum
Keyword(s):  
Ion Trap ◽  
Doping Control ◽  
Trap Detector ◽  
In Doping

Evaluation of AMGEN clone 9G8A anti-Epo antibody for application in doping control

2016 ◽  
Vol 8 (11-12) ◽  
pp. 1131-1137 ◽  
Author(s):  
Christian Reichel ◽  
Wolfgang Benetka ◽  
Barbara Lorenc ◽  
Mario Thevis
Keyword(s):  
Doping Control ◽  
In Doping

Investigation on the application of DNA forensic human identification techniques to detect homologous blood transfusions in doping control

Talanta ◽  
2013 ◽  
Vol 110 ◽  
pp. 28-31 ◽  
Author(s):  
Francesco Donati ◽  
Alessandra Stampella ◽  
Xavier de la Torre ◽  
Francesco Botrè
Keyword(s):  
Human Identification ◽  
Doping Control ◽  
Blood Transfusions ◽  
Homologous Blood ◽  
In Doping ◽  
Identification Techniques

Current role of LC-MS(/MS) in doping control

2011 ◽  
Vol 401 (2) ◽  
pp. 405-420 ◽  
Author(s):  
Mario Thevis ◽  
Andreas Thomas ◽  
Wilhelm Schänzer
Keyword(s):  
Doping Control ◽  
Current Role ◽  
In Doping

Carbon isotope mass spectrometry in doping control

2010 ◽  
Vol 65 (8) ◽  
pp. 825-832 ◽  
Author(s):  
T. G. Sobolevskii ◽  
I. S. Prasolov ◽  
G. M. Rodchenkov
Keyword(s):  
Mass Spectrometry ◽  
Carbon Isotope ◽  
Doping Control ◽  
In Doping
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