scholarly journals Two new genetically modified mouse alleles labeling distinct phases of retinal ganglion cell development by fluorescent proteins

2020 ◽  
Vol 249 (12) ◽  
pp. 1514-1528 ◽  
Author(s):  
Yichen Ge ◽  
Fuguo Wu ◽  
Mobin Cheng ◽  
Jonathan Bard ◽  
Xiuqian Mu
Keyword(s):  
Ganglion Cell ◽  
Retinal Ganglion Cell ◽  
Fluorescent Proteins ◽  
Genetically Modified ◽  
Cell Development ◽  
Retinal Ganglion

All Brn3 genes can promote retinal ganglion cell differentiation in the chick

Development ◽  
2000 ◽  
Vol 127 (15) ◽  
pp. 3237-3247 ◽  
Author(s):  
W. Liu ◽  
S.L. Khare ◽  
X. Liang ◽  
M.A. Peters ◽  
X. Liu ◽  
...  
Keyword(s):  
Ganglion Cell ◽  
Retinal Ganglion Cell ◽  
Ganglion Cells ◽  
Cell Development ◽  
Large Set ◽  
Retinal Ganglion ◽  
Pou Domain ◽  
Temporal Expression Pattern ◽  
Cell Genesis

Targeted gene disruption studies in the mouse have demonstrated crucial roles for the Brn3 POU domain transcription factor genes, Brn3a, Brn3b, Brn3c (now called Pou4f1, Pou4f2, Pou4f3, respectively) in sensorineural development and survival. During mouse retinogenesis, the Brn3b gene is expressed in a large set of postmitotic ganglion cell precursors and is required for their early and terminal differentiation. In contrast, the Brn3a and Brn3c genes, which are expressed later in ganglion cells, appear to be dispensable for ganglion cell development. To understand the mechanism that causes the functional differences of Brn3 genes in retinal development, we employed a gain-of-function approach in the chick embryo. We find that Brn3b(l) and Brn3b(s), the two isoforms encoded by the Brn3b gene, as well as Brn3a and Brn3c all have similar DNA-binding and transactivating activities. We further find that the POU domain is minimally required for these activities. Consequently, we show that all these Brn3 proteins have a similar ability to promote development of ganglion cells when ectopically expressed in retinal progenitors. During chick retinogenesis, cBrn3c instead of cBrn3b exhibits a spatial and temporal expression pattern characteristic of ganglion cell genesis and its misexpression can also increase ganglion cell production. Based on these data, we propose that all Brn3 factors are capable of promoting retinal ganglion cell development, and that this potential may be limited by the order of expression in vivo.

Pou4f2-GFPknock-in mouse line: A model for studying retinal ganglion cell development

genesis ◽  
2016 ◽  
Vol 54 (10) ◽  
pp. 534-541 ◽  
Author(s):  
Dongwang Zheng ◽  
Xiaoyan Yang ◽  
Donglai Sheng ◽  
Dongliang Yu ◽  
Guoqing Liang ◽  
...  
Keyword(s):  
Ganglion Cell ◽  
Retinal Ganglion Cell ◽  
Cell Development ◽  
Retinal Ganglion ◽  
Mouse Line

scholarly journals Molecular characterization and mapping of ATOH7, a human atonal homolog with a predicted role in retinal ganglion cell development

2002 ◽  
Vol 13 (2) ◽  
pp. 95-101 ◽  
Author(s):  
Nadean L. Brown ◽  
Susan L. Dagenais ◽  
Chuan-Min Chen ◽  
Tom Glaser
Keyword(s):  
Ganglion Cell ◽  
Molecular Characterization ◽  
Retinal Ganglion Cell ◽  
Cell Development ◽  
Retinal Ganglion

scholarly journals Retinal ganglion cell defects cause decision shifts in visually evoked defense responses

2020 ◽  
Vol 124 (5) ◽  
pp. 1530-1549
Author(s):  
Rebecca Nicole Lees ◽  
Armaan Fazal Akbar ◽  
Tudor Constantin Badea
Keyword(s):  
Ganglion Cell ◽  
Brain Stem ◽  
Retinal Ganglion Cell ◽  
Genetically Modified ◽  
Visual Stimuli ◽  
Defense Responses ◽  
Retinal Ganglion ◽  
Freezing Response ◽  
Response Choices ◽  
The Brain

Flight and freezing response choices evoked by visual stimuli are controlled by brain stem and thalamic circuits. Genetically modified mice with loss of specific retinal ganglion cell (RGC) subpopulations have altered flight versus freezing choices in response to some but not other visual stimuli. This finding suggests that “threatening” visual stimuli may be computed already at the level of the retina and communicated via dedicated pathways (RGCs) to the brain.

scholarly journals Disease Gene Candidates Revealed by Expression Profiling of Retinal Ganglion Cell Development

2007 ◽  
Vol 27 (32) ◽  
pp. 8593-8603 ◽  
Author(s):  
J. T. Wang ◽  
N. J. Kunzevitzky ◽  
J. C. Dugas ◽  
M. Cameron ◽  
B. A. Barres ◽  
...  
Keyword(s):  
Ganglion Cell ◽  
Retinal Ganglion Cell ◽  
Expression Profiling ◽  
Disease Gene ◽  
Cell Development ◽  
Retinal Ganglion

Retinal ganglion cell survival is promoted by genetically modified astrocytes designed to secrete brain-derived neurotrophic factor (BDNF)

1994 ◽  
Vol 647 (1) ◽  
pp. 30-36 ◽  
Author(s):  
B. Castillo ◽  
M. del Cerro ◽  
X.O. Breakefield ◽  
D.M. Frim ◽  
C.J. Barnstable ◽  
...  
Keyword(s):  
Ganglion Cell ◽  
Cell Survival ◽  
Retinal Ganglion Cell ◽  
Neurotrophic Factor ◽  
Genetically Modified ◽  
Brain Derived Neurotrophic Factor ◽  
Retinal Ganglion ◽  
Retinal Ganglion Cell Survival

Extrinsic determinants of retinal ganglion cell development in primates

1989 ◽  
Vol 286 (2) ◽  
pp. 170-189 ◽  
Author(s):  
Audie G. Leventhal ◽  
Steven J. Ault ◽  
Damgmar J. Vitek ◽  
Tiande Shou
Keyword(s):  
Ganglion Cell ◽  
Retinal Ganglion Cell ◽  
Cell Development ◽  
Retinal Ganglion
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