A transgenic Alx4‐CreER mouse to analyze anterior limb and nephric duct development

2021 ◽  
Author(s):  
Devan M. Rockwell ◽  
Amber K. O’Connor ◽  
Melissa R. Bentley‐Ford ◽  
Courtney J. Haycraft ◽  
Mandy J. Croyle ◽  
...  
Keyword(s):  
Duct Development

Cast titanium inlet duct development

1983 ◽  
Author(s):  
R. BURK ◽  
S. SCHWEDT
Keyword(s):  
Duct Development ◽  
Inlet Duct

scholarly journals Gain-of-function β-catenin in the uterine mesenchyme leads to impaired implantation and decidualization

2017 ◽  
Vol 233 (1) ◽  
pp. 119-130 ◽  
Author(s):  
Amanda L Patterson ◽  
Jamieson Pirochta ◽  
Stephanie Y Tufano ◽  
Jose M Teixeira
Keyword(s):  
Epithelial Cell ◽  
Early Pregnancy ◽  
Embryo Implantation ◽  
Junctional Complex ◽  
Mullerian Duct ◽  
Mesenchymal Tumors ◽  
Gain Of Function ◽  
Müllerian Duct ◽  
Duct Development

Embryo implantation and endometrial decidualization are critical events that occur during early pregnancy in humans and mice, and perturbation in either can result in infertility. WNT signaling through the canonical β-catenin pathway plays a pivotal role in embryonic Müllerian duct development, postnatal uterine maturation and establishment of pregnancy. Loss of β-catenin in the Müllerian duct mesenchyme (MDM)-derived stroma and myometrium results in impaired decidualization and infertility, whereas gain-of-function (GOF) results in the formation of mesenchymal tumors and sub-fertility attributed to malformed oviducts. We hypothesized that GOF β-catenin further contributes to sub-fertility through improper stromal and epithelial cell signaling during embryo implantation and decidualization. We show that mice with GOF β-catenin in MDM-derived stroma and myometrium have reduced implantation sites after embryo transfer and decreased decidualization. On day 4.5 of pseudopregnancy or in mice treated with progesterone and estrogen to mimic early pregnancy, the estrogen–LIF–ERK and progesterone–IHH pathways remain predominantly intact in GOF β-catenin mice; however, JAK/STAT signaling is altered. pSTAT3 is significantly reduced in GOF β-catenin mice and expression of downstream epithelial junctional complex factors, Ctnna1 and Cldn1, is increased. We also show that purified stromal cells from GOF β-catenin uteri, when removed from epithelial cell influence and provided with the appropriate hormonal stimuli, are able to decidualize in vitro indicating that the cells are intrinsically capable of decidualization. Taken together, these results suggest that dysregulated β-catenin activity in the stroma affects epithelial cell STAT3 signaling and ultimately embryo implantation and stromal decidualization.

Wolffian Duct Development

2014 ◽  
Vol 8 (5) ◽  
pp. 273-280 ◽  
Author(s):  
Geoffrey Shaw ◽  
Marilyn B. Renfree
Keyword(s):  
Wolffian Duct ◽  
Duct Development

scholarly journals Genital Duct Development on Streak Gonad Side in Fifteen Children with 45, X and Y-containing Chromosome Mosaicism

1993 ◽  
Vol 2 (1) ◽  
pp. 27-32
Author(s):  
Yoshihiro Kakizawa ◽  
Reiko Ito ◽  
Itsuro Hibi ◽  
Ayako Tanae ◽  
Toshiaki Tanaka ◽  
...  
Keyword(s):  
Genital Duct ◽  
Chromosome Mosaicism ◽  
Duct Development

N- and E-cadherin expression in human ovarian and urogenital duct development

2010 ◽  
Vol 93 (7) ◽  
pp. 2348-2353 ◽  
Author(s):  
Sarah R. Smith ◽  
Norma Fulton ◽  
Craig S. Collins ◽  
Michelle Welsh ◽  
Rosey A.L. Bayne ◽  
...  
Keyword(s):  
Duct Development ◽  
E Cadherin

A CASE OF HEPATOCELLULAR CARCINOMA WITH INTRAHEPATIC BILE DUCT DEVELOPMENT WITHOUT OBSTRUCTIVE JAUNDICE

1993 ◽  
Vol 54 (6) ◽  
pp. 1612-1616
Author(s):  
Ryuji HIRAI ◽  
Syuichi NOMURA ◽  
Yoshiyuki USUI ◽  
Sumiji SASAKI ◽  
Kazuhiko HAYASHI
Keyword(s):  
Hepatocellular Carcinoma ◽  
Bile Duct ◽  
Obstructive Jaundice ◽  
Intrahepatic Bile Duct ◽  
Duct Development

Gum Duct Development in Almond Fruit, Prunus dulcis (Mill.) D. A. Webb

1985 ◽  
Vol 146 (1) ◽  
pp. 15-25 ◽  
Author(s):  
Janice C. Morrison ◽  
Vito S. Polito
Keyword(s):  
Prunus Dulcis ◽  
Duct Development
Sign in / Sign up

Export Citation Format

Share Document