Tissue-specific regulation of the human acute-phase serum amyloid A genes,SAA1 andSAA2, by glucocorticoids in hepatic and epithelial cells

2003 ◽  
Vol 33 (9) ◽  
pp. 2630-2639 ◽  
Author(s):  
Caroline F. Thorn ◽  
Zhi-Yong Lu ◽  
Alexander S. Whitehead
2013 ◽  
Vol 6 (1) ◽  
Author(s):  
Michelle B Christensen ◽  
Jens Christian Sørensen ◽  
Stine Jacobsen ◽  
Mads Kjelgaard-Hansen

2011 ◽  
Vol 216 (2) ◽  
pp. 266-268
Author(s):  
Sidika Karakas ◽  
Rami Mortada ◽  
Clinical Fellow

1979 ◽  
Vol 150 (3) ◽  
pp. 597-606 ◽  
Author(s):  
J D Sipe ◽  
S N Vogel ◽  
J L Ryan ◽  
K P McAdam ◽  
D L Rosenstreich

The mechanism by which LPS stimulates an acute phase serum amyloid A (SAA) response in C3H mice has been studied. A factor (SAA inducer) appears in the blood of C3H/HeN (lipopolysaccharide [LPS]-sensitive) mice approximately 1 h after administration of LPS, which, when passively administered, can induce C3H/HeJ mice to produce SAA although they are resistant to the LPS itself. SAA inducer has been detected in the culture medium of LPS treated C3H/HeN macrophages but not spleen cells. Thus, two stages in the induction of the acute phase SAA response are now recognized: a latent period of 2-3 h during which the SAA concentration remains at baseline values and in which SAA inducer appears, and the period of synthesis of SAA which lasts for approoximately 24 h past induction. It is proposed that a macrophage response to LPS is responsible for production of the serum mediator which induces SAA synthesis.


1982 ◽  
Vol 389 (1 C-Reactive Pr) ◽  
pp. 137-150 ◽  
Author(s):  
Jean D. Sipe ◽  
Stefanie N. Vogel ◽  
Marcela B. Sztein ◽  
Martha Skinner ◽  
Alan S. Cohen

FEBS Letters ◽  
1995 ◽  
Vol 374 (2) ◽  
pp. 241-245 ◽  
Author(s):  
Derval J. Gaughan ◽  
Diana M. Steel ◽  
Alexander S. Whitehead

2004 ◽  
pp. 212-214 ◽  
Author(s):  
Y. Kumon ◽  
K. Arii ◽  
T. Suehiro ◽  
Y. Ikeda ◽  
H. Enzan ◽  
...  

PLoS Genetics ◽  
2010 ◽  
Vol 6 (11) ◽  
pp. e1001213 ◽  
Author(s):  
Carola Marzi ◽  
Eva Albrecht ◽  
Pirro G. Hysi ◽  
Vasiliki Lagou ◽  
Melanie Waldenberger ◽  
...  

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