scholarly journals AIRE: From promiscuous molecular partnerships to promiscuous gene expression

2015 ◽  
Vol 46 (1) ◽  
pp. 22-33 ◽  
Author(s):  
Jakub Abramson ◽  
Yael Goldfarb
Keyword(s):  
Gene Expression ◽  
Promiscuous Gene Expression

Promiscuous gene expression and central T-cell tolerance: more than meets the eye

2002 ◽  
Vol 23 (7) ◽  
pp. 364-371 ◽  
Author(s):  
Bruno Kyewski ◽  
Jens Derbinski ◽  
Jörn Gotter ◽  
Ludger Klein
Keyword(s):  
Gene Expression ◽  
T Cell ◽  
T Cell Tolerance ◽  
Cell Tolerance ◽  
Promiscuous Gene Expression

scholarly journals Biologically indeterminate yet ordered promiscuous gene expression in single medullary thymic epithelial cells

2019 ◽  
Vol 39 (1) ◽  
Author(s):  
Fatima Dhalla ◽  
Jeanette Baran‐Gale ◽  
Stefano Maio ◽  
Lia Chappell ◽  
Georg A Holländer ◽  
...  
Keyword(s):  
Gene Expression ◽  
Epithelial Cells ◽  
Thymic Epithelial Cells ◽  
Medullary Thymic Epithelial Cells ◽  
Promiscuous Gene Expression

Evidence for a network transcriptional control of promiscuous gene expression in medullary thymic epithelial cells

2009 ◽  
Vol 46 (16) ◽  
pp. 3240-3244 ◽  
Author(s):  
Cláudia Macedo ◽  
Adriane F. Evangelista ◽  
Danielle A. Magalhães ◽  
Thaís A. Fornari ◽  
Leandra L. Linhares ◽  
...  
Keyword(s):  
Gene Expression ◽  
Epithelial Cells ◽  
Transcriptional Control ◽  
Thymic Epithelial Cells ◽  
Medullary Thymic Epithelial Cells ◽  
Promiscuous Gene Expression

scholarly journals An evolutionarily conserved mutual interdependence between Aire and microRNAs in promiscuous gene expression

2013 ◽  
Vol 43 (7) ◽  
pp. 1769-1778 ◽  
Author(s):  
Olga Ucar ◽  
Lars-Oliver Tykocinski ◽  
James Dooley ◽  
Adrian Liston ◽  
Bruno Kyewski
Keyword(s):  
Gene Expression ◽  
Evolutionarily Conserved ◽  
Promiscuous Gene Expression

scholarly journals Contrasting models of promiscuous gene expression by thymic epithelium

2005 ◽  
Vol 202 (1) ◽  
pp. 15-19 ◽  
Author(s):  
Geoffrey O. Gillard ◽  
Andrew G. Farr
Keyword(s):  
Gene Expression ◽  
Epithelial Cells ◽  
Broad Spectrum ◽  
Alternative Model ◽  
Thymic Epithelial Cells ◽  
Central Tolerance ◽  
Thymic Epithelium ◽  
Medullary Thymic Epithelial Cells ◽  
Promiscuous Gene Expression ◽  
Self Antigens

Medullary thymic epithelial cells (mTECs) express a broad spectrum of tissue- restricted self-antigens (TRAs), which are required for the development of central tolerance. A new study suggests that TRA expression is a specialized property of terminally differentiated mTECs. However, as discussed here, an alternative model—whereby TRA expression is regulated by conserved developmental programs active in developing mTECs—may be equally plausible.

scholarly journals Decreased AIRE and promiscuous gene expression in thymus from Down syndrome individuals may explain predisposition to autoimmunity

2012 ◽  
Vol 10 (S3) ◽  
Author(s):  
Roger Colobran ◽  
Maria del Pilar Armengol ◽  
Eduard Porta ◽  
Paula A Correa ◽  
Ricardo Pujol-Borrell
Keyword(s):  
Gene Expression ◽  
Down Syndrome ◽  
Promiscuous Gene Expression
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