Contrasting models of promiscuous gene expression by thymic epithelium
2005 ◽
Vol 202
(1)
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pp. 15-19
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Keyword(s):
Medullary thymic epithelial cells (mTECs) express a broad spectrum of tissue- restricted self-antigens (TRAs), which are required for the development of central tolerance. A new study suggests that TRA expression is a specialized property of terminally differentiated mTECs. However, as discussed here, an alternative model—whereby TRA expression is regulated by conserved developmental programs active in developing mTECs—may be equally plausible.
2014 ◽
Vol 194
(3)
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pp. 921-928
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2012 ◽
Vol 190
(3)
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pp. 1085-1093
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2009 ◽
Vol 46
(16)
◽
pp. 3240-3244
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2007 ◽
Vol 37
(12)
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pp. 3363-3372
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2008 ◽
Vol 105
(2)
◽
pp. 657-662
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