Neural Anti-Inflammatory Natural Product Periconianone A: Total Synthesis and Biological Evaluation

2019 ◽  
Vol 2019 (13) ◽  
pp. 2376-2381 ◽  
Author(s):  
Hanuman P. Kalmode ◽  
Suhag S. Patil ◽  
Kishor L. Handore ◽  
Paresh R. Athawale ◽  
Rambabu Dandela ◽  
...  
Keyword(s):  
Total Synthesis ◽  
Natural Product ◽  
Biological Evaluation ◽  
Anti Inflammatory ◽  
Synthesis And Biological Evaluation

Total synthesis and biological evaluation of viscolin, a 1,3-diphenylpropane as a novel potent anti-inflammatory agent

2006 ◽  
Vol 16 (24) ◽  
pp. 6155-6160 ◽  
Author(s):  
Chung-Ren Su ◽  
Yuh-Chiang Shen ◽  
Ping-Chung Kuo ◽  
Yann-Lii Leu ◽  
Amooru G. Damu ◽  
...  
Keyword(s):  
Total Synthesis ◽  
Biological Evaluation ◽  
Inflammatory Agent ◽  
Anti Inflammatory ◽  
Synthesis And Biological Evaluation

Total synthesis and biological evaluation of seven new anti-inflammatory oxacyclododecindione-type macrolactones

2020 ◽  
Vol 18 (30) ◽  
pp. 5906-5917
Author(s):  
Carina Weber ◽  
Nina Vierengel ◽  
Thorsten Walter ◽  
Torsten Behrendt ◽  
Tobias Lucas ◽  
...  
Keyword(s):  
Total Synthesis ◽  
Inhibitory Activity ◽  
Biological Evaluation ◽  
Signalling Pathways ◽  
Anti Inflammatory ◽  
Synthesis And Biological Evaluation

Seven new macrolactones of the oxacyclododecindione family have been synthesized and tested for their inhibitory activity on TGF-β-inducible Smad2/3- as well as IL-4-inducible STAT6-dependent signalling pathways.

Total synthesis and biological evaluation of the natural product (−)-cyclonerodiol, a new inhibitor of IL-4 signaling

2014 ◽  
Vol 12 (47) ◽  
pp. 9707-9715 ◽  
Author(s):  
Jens Langhanki ◽  
Kristina Rudolph ◽  
Gerhard Erkel ◽  
Till Opatz
Keyword(s):  
Total Synthesis ◽  
Natural Product ◽  
Specific Inhibitor ◽  
Biological Evaluation ◽  
Synthesis And Biological Evaluation

The sesquiterpene (−)-cyclonerodiol is a specific inhibitor of IL-4 induced STAT6 signaling and is readily available from (−)-linalool.

scholarly journals Total Synthesis and Biological Evaluation of the Tetramic Acid Based Natural Product Harzianic Acid and Its Stereoisomers

2015 ◽  
Vol 17 (3) ◽  
pp. 692-695 ◽  
Author(s):  
Alan R. Healy ◽  
Francesco Vinale ◽  
Matteo Lorito ◽  
Nicholas J. Westwood
Keyword(s):  
Total Synthesis ◽  
Natural Product ◽  
Biological Evaluation ◽  
Tetramic Acid ◽  
Synthesis And Biological Evaluation

scholarly journals Total Synthesis and Biological Evaluation of Apratoxin E and Its C30 Epimer: Configurational Reassignment of the Natural Product

2016 ◽  
Vol 18 (20) ◽  
pp. 5400-5403 ◽  
Author(s):  
Ping Wu ◽  
Weijing Cai ◽  
Qi-Yin Chen ◽  
Senhan Xu ◽  
Ruwen Yin ◽  
...  
Keyword(s):  
Total Synthesis ◽  
Natural Product ◽  
Biological Evaluation ◽  
Synthesis And Biological Evaluation

Synthesis and Biological Evaluation of the Antimicrobial Natural Product Lipoxazolidinone A

2018 ◽  
Author(s):  
Jonathan J. Mills ◽  
Kaylib R. Robinson ◽  
Troy E. Zehnder ◽  
Joshua G. Pierce
Keyword(s):  
Natural Products ◽  
Natural Product ◽  
Mechanism Of Action ◽  
Marine Natural Products ◽  
Biological Evaluation ◽  
Lead Compounds ◽  
Follow Up Studies ◽  
Initial Resistance ◽  
Synthesis And Biological Evaluation

The lipoxazolidinone family of marine natural products, with an unusual 4-oxazolidinone heterocycle at their core, represents a new scaffold for antimicrobial discovery; however, questions regarding their mechanism of action and high lipophilicity have likely slowed follow-up studies. Herein, we report the first synthesis of lipoxazolidinone A, 15 structural analogs to explore its active pharmacophore, and initial resistance and mechanism of action studies. These results suggest that 4-oxazolidinones are valuable scaffolds for antimicrobial development and reveal simplified lead compounds for further optimization.

Docking Studies, Synthesis and Biological Evaluation of β-aryl-β-hydroxy Propanoic Acids for Anti-inflammatory Activity

2017 ◽  
Vol 13 (2) ◽  
pp. 186-195 ◽  
Author(s):  
Jelena Savic ◽  
Sanda Dilber ◽  
Marina Milenkovic ◽  
Jelena Kotur-Stevuljevic ◽  
Bojan Markovic ◽  
...  
Keyword(s):  
Docking Studies ◽  
Biological Evaluation ◽  
Inflammatory Activity ◽  
Anti Inflammatory ◽  
Synthesis And Biological Evaluation

scholarly journals Xylochemical Synthesis and Biological Evaluation of Shancigusin C and Bletistrin G

Molecules ◽  
2021 ◽  
Vol 26 (11) ◽  
pp. 3224
Author(s):  
Leander Geske ◽  
Ulrich Kauhl ◽  
Mohamed E. M. Saeed ◽  
Anja Schüffler ◽  
Eckhard Thines ◽  
...  
Keyword(s):  
Total Synthesis ◽  
Biological Activities ◽  
Biological Evaluation ◽  
Aromatic Substitution ◽  
Substitution Reactions ◽  
Total Syntheses ◽  
Wittig Olefination ◽  
Starting Point ◽  
Perkin Reaction ◽  
Synthesis And Biological Evaluation

The biological activities of shancigusin C (1) and bletistrin G (2), natural products isolated from orchids, are reported along with their first total syntheses. The total synthesis of shancigusin C (1) was conducted by employing the Perkin reaction to forge the central stilbene core, whereas the synthesis of bletistrin G (2) was achieved by the Wittig olefination followed by several regioselective aromatic substitution reactions. Both syntheses were completed by applying only renewable starting materials according to the principles of xylochemistry. The cytotoxic properties of shancigusin C (1) and bletistrin G (2) against tumor cells suggest suitability as a starting point for further structural variation.

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